The rhesus R5 - ZFNs and X4 - ZFNs were delivered by Ad5 / F35 vector at MOIs from 600 — 2000 into
rhesus CD4 + T cells.
Not exact matches
But if you put that same virus into a
rhesus macaque, the monkey's immune system reacts similarly to that of humans; there is severe depletion of
CD4 T cells and progression to AIDS, explains U.C.S.F. researcher Peter Hunt.
Whole blood from
rhesus macaques (Macaca mulatta) housed at the Tulane National Primate Research Center was used for
CD4 + T cell isolation and ZFN treatment.
To study this in the most rigorous way possible, we have explored the possibility of targeting CCR5 and CXCR4 in
CD4 + T cells derived from
rhesus macaques.
CMMT (a
rhesus macaque mammary tumor line) infected with the amphotropic retroviral vector LT4SN to express human
CD4.
The research showed evidence that in
rhesus macaques infected with simian immunodeficiency virus (SIV), the monkey form of HIV, loss of IL - 17 producing
CD4 + and CD8 + T cells was associated with damage to the colon epithelium and with immune activation (see Monkey Matters, IAVI Report, Nov. - Dec.