Sentences with word «rhinovirus»

The atomic resolution structure of a strain of rhinovirus C.

For instance, Liu uncovered physical features of rhinovirus C that help explain why it is resistant to standard antiviral treatments, how it interacts with cells to cause infection, and why it behaves as a different disease from other members of the enterovirus family.

Asthma affects an estimated 24 million people in the U.S. and asthmatic children infected with rhinovirus C have been shown in previous studies to have more severe asthma symptoms.

They compared the 128 patients with rhinovirus in the lower respiratory tract to those infected with viruses already known to cause pneumonia — and sometimes death — in transplant patients, namely, influenza; parainfluenza virus, or PIV; and respiratory syncytial virus, or RSV.

In principle, if further tests bear out the protective effects of the two antibodies, then optimized versions of them, or small - molecule drugs that hit the same target, could be developed as treatments for rhinovirus infections.

J. Owen Hendley, a pediatrician at the University of Virginia School of Medicine in Charlottesville, and his colleagues obtained mucus samples from 15 people who had active rhinovirus infections.

Images of Human Rhinovirus 14 (2016)-- the common cold virus — built with open - source modelling programmes, are projected onto several beach balls floating in the air.

That's why scientists, investigating an outbreak of respiratory disease in a community of wild chimpanzees in Uganda's Kibale National Park, were surprised and dismayed to discover that a human «common cold» virus known as rhinovirus C was killing healthy chimps.

In the future, development of drugs that block CDHR3 potentially could help prevent and treat illnesses caused by rhinovirus C.

The findings provide the foundation for future antiviral drug and vaccine development against rhinovirus C.

The new findings help clarify the function of CDHR3 and point to a novel target for the development of prevention and treatment strategies against rhinovirus C - induced colds and asthma attacks.

Researchers led by James Gern, M.D., at the University of Wisconsin - Madison, discovered that CDHR3 recognizes and binds rhinovirus C, enabling the virus to enter human cells.

«So many of our patients get rhinovirus, but most of the infections are mild and we want to know who would likely benefit from any potential therapies,» Waghmare said.

They compared the immune response to rhinovirus when cells were incubated at 37 degrees Celsius, or core body temperature, and at the cooler 33 degrees Celsius.

Even though there's no effective drug for rhinovirus on the market yet, understanding who is at highest risk of complications from the virus is still important, Waghmare said.

More specifically, infection by RSV accounted for 69.9 % of the cases, while rhinovirus accounted for 26.5 %.

«No other rhinoviruses seem to do this naturally.»

Gern's lab was the first to grow rhinovirus C in the laboratory where it could be studied.

Dr. Alpana Waghmare, one of the study authors who is a pediatric infectious disease specialist at Seattle Children's and a Fred Hutch affiliate researcher, is launching a research project to better understand how and why rhinovirus is so dangerous to transplant patients.

Come back only when the scent of peach and butter and caramel has filled your home, enough to penetrate even your nose's rhinovirus ether.

It could be a common rhinovirus, or it could be a completely new organism.

The research field needs to provide evidence of how rhinovirus is harmful to spur such a drug's development as well as to understand which patients would benefit most once such a treatment is available so clinicians can know who should be monitored or treated more aggressively, she said.

Even though rhinovirus is less likely on a case - by - case basis to lead to pneumonia, it's actually the most common cause of pneumonia caused by respiratory viruses in transplant patients, Boeckh said.

Although the research was conducted on mouse cells, it offers clues that may benefit people, including the roughly 20 % of us who harbor rhinovirus in our noses at any given time.

But once patients developed pneumonia, rhinovirus turned out to be just as deadly as the other viruses, the researchers found.

«This is such a prevalent virus... about 25 percent of stem cell transplant patients get infected [with rhinovirus] during the first year,» said Boeckh, who heads Fred Hutch's Infectious Disease Sciences Program.

«Our findings — that statins reduce rhinovirus - induced CXCL10 secretion from human monocytic cells — suggest that these frequently prescribed drugs may affect asthma exacerbations caused by the common cold in adults,» said Lisa E. Wickert, Ph.D., a researcher involved in the work from the Department of Biomolecular Chemistry and Nutritional Sciences at the University of Wisconsin - Madison in Madison, Wisconsin.

Notably, cells bearing a specific CDHR3 gene variant showed greatly enhanced rhinovirus C binding and produced more progeny virus than cells with normal CDHR3.

In all, 52 of 150 tested surfaces had detectable rhinovirus traceable to the study participant who had stayed there.

Looking at large numbers of rhinovirus genomes may provide answers.

Finding rhinovirus C as the cause of the 2013 outbreak in Uganda was part good luck, says Goldberg.

Palmenberg and Rossmann have collaborated for 34 years, ever since her former mentor, UW — Madison professor emeritus Roland Rueckert, and Rossmann collaborated to become the first to determine the structure of rhinovirus B.

«Unlike normal rhinoviruses, this one has spikes on the surface of the particles.

While learning how to culture rhinovirus C, Palmenberg's research team discovered the virus only infects certain lung cells that express a particular genetic form of a cell - surface molecule called cadherin - related protein 3 (CDHR3).

Generation of a Th2 microenvironment through interleukin - 13 (IL - 13) stimulation induced features of asthmatic airways and induced vascular wall activation through increased expression of E - and P - Selectin, but did not alter rhinovirus growth.

A couple of weeks later, they brought them into the lab and injected live rhinovirus into their nose.

Lab results show that state of the art colloidal silver products can provide you with candida relief as well as eliminate the dangerous rhinovirus.

Researchers have hypothesized that zinc could reduce the severity and duration of cold symptoms by directly inhibiting rhinovirus binding and replication in the nasal mucosa and suppressing inflammation [65,66].

When you feel a cold in your sinuses, most of the time you're dealing with the germ rhinovirus.

Ginger contains sesquiterpenes, antiseptic and anti-inflammatory chemicals, that act on rhinovirus specifically.

• Cold viruses, i.e. rhinovirus, thrive in lower humidity.

Rhinoviruses survive for three hours outside of the body, and can sometimes live for up to 48 hours on touchable surfaces, including everything from door knobs and subway poles to shopping carts and light switches.

Emotional style, nasal cytokines, and illness expression after experimental rhinovirus exposure

The supplement has been found to stop rhinoviruses from replication and could block the virus from latching on to human cells.

The most common are called human rhinoviruses (HRV), and are the little jerks that cause up to 40 percent of all colds.

The new findings suggest that this gene variant could be a risk factor for childhood wheezing illnesses caused by rhinovirus C, which in turn may increase the risk of developing asthma.

Boeckh and his colleagues found that rhinovirus infection led to pneumonia less often than the other viruses.

Polymorphism frequencies were also analyzed for each type of virus, including RSV subtypes A and B, as well as rhinovirus, and possible cases of virus co-detection were identified.