Boeckh and his colleagues found that
rhinovirus infection led to pneumonia less often than the other viruses.
In principle, if further tests bear out the protective effects of the two antibodies, then optimized versions of them, or small - molecule drugs that hit the same target, could be developed as treatments for
rhinovirus infections.
Not exact matches
In contrast to what researchers believed in the past, their study showed that
rhinovirus is linked to pneumonia and death even without any other co-existing
infections, strongly suggesting that the so - called mild virus can be dangerous all on its own.
«So many of our patients get
rhinovirus, but most of the
infections are mild and we want to know who would likely benefit from any potential therapies,» Waghmare said.
Her team's next step will be to understand whether certain patients are at higher risk for getting infected with
rhinovirus in the first place and to ask if there are other risk factors for pneumonia and other poor outcomes from the
infection.
In one study 10 subjects handled a coffee cup contaminated with
rhinovirus — and half subsequently developed an
infection.
This
rhinovirus reliably kills HeLa cells, a line of human - derived cells that have long been used in studies of viral
infection.
The scientists identified CDHR3 as a potential candidate by analyzing cells that either were or were not susceptible to
rhinovirus C
infection.
Differences in the Nasopharyngeal Microbiome During Acute Respiratory Tract
Infection With Human
Rhinovirus and Respiratory Syncytial Virus in Infancy.
In people,
rhinovirus C
infection can be especially severe in children, notes James Gern, another senior author of the study and a professor of allergy and immunology in the UW School of Medicine and Public Health.
For instance, Liu uncovered physical features of
rhinovirus C that help explain why it is resistant to standard antiviral treatments, how it interacts with cells to cause
infection, and why it behaves as a different disease from other members of the enterovirus family.
For some people (young children, in particular)
rhinovirus C
infection can be a precursor or complicating factor for asthma.
Rhinovirus C
infections are also a major contributor to poor outcomes for people with chronic lung conditions like cystic fibrosis, and early exposure to the virus can cause lifelong lung scarring leading to persistent respiratory difficulties later, says Palmenberg.
Infection with human
rhinovirus, the most common cause of asthma exacerbation in adults and children, was restricted to ciliated cells and resulted in ciliated cell apical sloughing and goblet cell hyperplasia, replicating hallmarks of cytopathology observed in vivo.
It's the most prevalent type of upper respiratory
infection (URI) and is caused by a virus (
rhinovirus).