Sentences with phrase «ribose polymerase»

Designed assays to evaluate novel drugs, with an emphasis on cellular pathways involving the enzymes poly - ADP - ribose polymerase, poly - ADP ribose glycohydrolase, cyclophilins and sirtuins.

Loss of HR accounts for the genomic instability of EOCs and for their cellular hyper - dependence on alternative poly - ADP ribose polymerase (PARP)- mediated DNA repair mechanisms.

PARP (Poly ADP - Ribose Polymerase) inhibitors, such as olaparib, are targeted drugs that block an enzyme involved in many functions in the cell, including the repair of DNA damage.

Olaparib blocks this second repair pathway by inhibiting an enzyme called poly ADP ribose polymerase (PARP).

Ali found that breast cancer cells that have high levels of RYBP are more sensitive to DNA damage after radiation or drug treatment, including PARP inhibitors (inhibitors of the enzyme poly ADP ribose polymerase used in cancer treatment).

One was a DNA methyltransferase (DNMT) inhibitor, while the other was a poly - ADP - ribose polymerase (PARP) inhibitor, talazoparib.

Not exact matches

In response, cells activate an enzyme called poly (ADP - ribose) polymerase (PARP) to repair DNA damage.

Poly (ADP - ribose) polymerase inhibitors (PARPis) are DNA - damaging agents that trap PARP - DNA complexes and interfere with DNA replication.

Poly (ADP - ribose) polymerase (PARP) inhibitors are effective in a broad population of patients with ovarian cancer; however, resistance caused by low enzyme expression of the drug target...

We also apply these techniques to model systems in order to identify subgroups of patients who are uniquely sensitive or resistant to targeted therapies, such as poly (ADP - ribose) polymerase (PARP) inhibitors or immune checkpoint blockade.

Indeed, at least in part, the abnormalities in homologous recombination deficiency have contributed to the very outstanding responses to platinum therapy and very striking new data with PARP (poly [ADP - ribose] polymerase) inhibitors.

Another strategy may be utilize NAD + precursors, or blocking its consumption by poly (ADP - ribose) polymerase (PARP) enzymes to reach the same benefic effect especially in subject with high predisposition to age related disease 40.

Identification of Poly (ADP - ribose) Polymerase - 1 (PARP - 1) as a Novel Krüppel - like Factor 8 - interacting and - regulating Protein.