In vivo mutational analysis of this nucleotide indicates that it has an essential role in
ribosomal function.
Not exact matches
That was surprising, he explains, because «fibrillarin resides deep within the nucleolus of the host cell... [where it] methylates
ribosomal RNA molecules, which then go on to form ribosomes,» but its full
function may not be completely understood.
Moreover, a funnel - shaped pore in the Sec61 oligomer aligned with the exit of a tunnel traversing the large
ribosomal subunit, strongly suggesting that both structures
function together in the translocation of proteins across the endoplasmic reticulum membrane.
The next step was to determine which of these sequences could
function as internal
ribosomal initiation sites.
Roughly 20 percent of the translation enhancing elements
functioned as internal
ribosomal initiation sites, again turning up primarily in non-coding genomic regions.
However if the ribosome skipped the hairpin and recognized the sequence on the other side of the hairpin independently and translated it, that's an indication that the sequence is
functioning as an internal
ribosomal initiation site.»
«Amazingly, when the
ribosomal mutant mice and the Pten mutant mice were bred together, stem cell
function returned to normal, and we greatly delayed, and in some instances entirely blocked, the development of leukemia,» Dr. Morrison said.
Ba Q, Li X, Huang C, Li J, Fu Y, Chen P, Duan J, Hao M, Zhang Y, Li J, Sun C, Ying H, Song H, Zhang R, Shen Z, Wang H. BCCIPbeta modulates the
ribosomal and extraribosomal
function of S7 through a direct interaction.
Biological
Function of
Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu J. Cancer 2018; 9 (4): 745 - 756.