In fact, this study reveals something heretofore unknown:
ribosomes do not have to be promiscuous to work — the two units that usually combine and separate can be tethered together permanently without killing the cell.
«But the ribosome didn't make mistakes.
Not exact matches
Ban and Poul Nissen, a membrane protein researcher at the Aarhus University in Denmark who was also
doing a postdoc in Steitz's lab at the time, pushed to determine the structure of the large subunit of the
ribosome at high resolution.
Venkatraman Ramakrishnan, Thomas Steitz and Ada Yonath first determined how to image the
ribosome, then revealed how it
does its protein - making work
«Under warmer temperatures, marine micro-algae
do not seem to produce as many
ribosomes as under lower temperatures.
If the necessary
ribosome - associated quality control machinery (RQC)
does not function properly, defective proteins accumulate and form toxic aggregates in the cytoplasm of the cells.
Too much structure could force the
ribosome to
do extra work untangling the strand or even stall translation altogether.
Despite all these novel properties, Pandoraviruses display the essential characteristics of other viruses in that they contain no
ribosome, produce no energy and
do not divide.
Some mRNAs also contain introns, extra sequences that
do not encode protein and must be spliced out before they journey to the
ribosome.
However, if exercise restores or prevents deterioration of mitochondria and
ribosomes in muscle cells, there's a good chance it
does so in other tissues, too.
«We have ample evidence that hundreds of the oldest ribosomal proteins still start with a valine or a leucine code and
do not have the codon for methionine in the DNA,» Duax said, referring to proteins found in basic cell components called
ribosomes.
The
ribosome has two key subunits, made of proteins and RNA, that
do the work of pulling together and assembling amino acids.
So there has been tremendous progress in that; we have certain proof of principle
ribosomes that are RNA dependent, RNA polymerases, which is great, but I think we really have to step back and think about the problem in a different way in order to develop a simple, effective system that can actually
do self - replication and not just be a proof of principle.
To
do that, the spectinamides bind to a particular site on
ribosomes that is not shared by other TB drugs.
That fact that mitochondria have their own DNA, RNA, and
ribosomes, supports the endosymbiosis theory, as
does the existence of the amoeba, a eukaryotic organism that lacks mitochondria and therefore requires a symbiotic relationship with an aerobic bacterium.
Chloramphenicol acts on the protein manufacturing system of bacteria (the cell's
ribosomes) yet
does not affect mammalian, reptilian, or avian
ribosomes.