Sentences with phrase «ribosomes during»
A segment of the 5» nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation.
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Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during translation of the upstream TnaC leader peptide, a process for which interactions between the TnaC nascent chain and the ribosomal exit tunnel are critical.
We determined a 5.8 angstrom — resolution cryo — electron microscopy and single - particle reconstruction of a ribosome stalled during translation of the tnaC leader gene.
Interestingly, the researchers found that shuttling ribosomes between the ER and the cytoplasm during stress only affected the subset of mRNAs that would give rise to secreted proteins like hormones or membrane proteins like growth factor receptors — the types of proteins that set off the stress response if they're misfolded.
In the second, they worked out the conditions required to allow their synthetic helix to be appended to natural proteins during synthesis by cellular ribosomes.
As a consequence, at a certain point during translation, the conformation of the ribosome's active site is distorted in such a way that further elongation of the nascent peptide becomes impossible.
Elongation factor G (EF - G) is a guanosine triphosphatase (GTPase) that plays a crucial role in the translocation of transfer RNAs (tRNAs) and messenger RNA (mRNA) during translation by the ribosome.
During this crucial step, messenger RNA (mRNA), which is a RNA copy of a gene's recipe for a protein, is translated by the cell's ribosome into the sequence of amino acids that will make up a newly synthesized protein.
To visualize translation, Dr. Singer and his colleagues took advantage of a key occurrence during the first round of translation: the ribosome to which mRNAs attach must displace so - called RNA - binding proteins from the mRNAs.
This 3.6 - Å - resolution cryo - EM map shows a ribosome (blue and light yellow) complexed with tRNAs (brown and green) and elongation factor G (red), during a crucial step in protein synthesis.