Sentences with phrase «ribosomes function»

That's where translation, the second step in protein synthesis, occurs: the mRNAs attached to ribosomes function as templates on which proteins are constructed.

She is examining the molecular details of how antibiotics and viruses perturb ribosome function.

Not exact matches

That was surprising, he explains, because «fibrillarin resides deep within the nucleolus of the host cell... [where it] methylates ribosomal RNA molecules, which then go on to form ribosomes,» but its full function may not be completely understood.

Allan Jacobson, Ph.D., of the University of Massachusetts Medical School and co-founder of PTC Therapeutics, the company that developed ataluren, and David Bedwell, Ph.D., professor of the UAB Department of Biochemistry and Molecular Genetics, have sought to understand precisely how ataluren allows the ribosome, the machinery of cellular protein synthesis, to skip over these inserted stop signs and produce proteins that have normal or near - normal function.

If the necessary ribosome - associated quality control machinery (RQC) does not function properly, defective proteins accumulate and form toxic aggregates in the cytoplasm of the cells.

Roughly half of all antibiotics attack pathogens» ribosomes, so understanding how the drugs fit into and disturb ribosomes» proper functioning could enable the discovery of new antibiotics to help stem the tide of rising antibiotic resistant strains.

Steitz shared the 2009 chemistry Nobel for his elegant elucidation of the three - dimensional structure and detailed function of the ribosome, the cellular organelle charged with the actual production of proteins as per the instructions of the genetic code.

And in fact it very well might be that once the ribosomes cease functioning properly, then anything can cause bees to go under.»

To find out why, computational biologists came up with a computer model to predict how microbial metabolism and cellular composition change as cell size varies, using details about how much space a bacterium needs for its components — DNA, proteins, and the molecular factories called ribosomes — to function.

Joint winner of the 2009 chemistry prize with Thomas Steitz and Ada Yonath «for studies of the structure and function of the ribosome.»

In nerve cells, ribosomes are also found close to the synapses of the dendrites, thus enabling proteins that are required for synaptic function to be produced close to their sites of action.

It encodes structural components of ribosomes, the miniature factories responsible for producing the proteins that carry out many functions of the cell.

The new organelle is three times as large as a ribosome and may be just as important for the cell's functioning.

This new class of antibiotics works against TB by disrupting the function of a part of the cell known as the ribosome, which is responsible for protein synthesis.

However if the ribosome skipped the hairpin and recognized the sequence on the other side of the hairpin independently and translated it, that's an indication that the sequence is functioning as an internal ribosomal initiation site.»

Bacterial ribosomes stalled on defective messenger RNAs (mRNAs) are rescued by tmRNA, an ∼ 300 - nucleotide - long molecule that functions as both transfer RNA (tRNA) and mRNA.

The structure indicates the extent of RNA packing required for the function of large ribozymes, the spliceosome, and the ribosome.

The structure reveals how tmRNA could move through the ribosome despite its complicated topology and also suggests roles for proteins S1 and SmpB in the function of tmRNA.

Getting at a mechanism for how DNA sequence could influence protein function, the researchers found that ribosomes density on β - actin RNA is more than a thousand times higher than on γ - actin RNA, and indeed all six actin genes had differences in ribosome density.

This study reveals a new function for Hfq in ribosome biogenesis with implications for translational control.

Nobel Laureate Ada Yonath, who was awarded the 2009 Nobel Prize in Chemistry «for studies of the structure and function of the ribosome «with X-ray crystallography, is currently researching species - specific antibiotics.

Wolin and her colleagues had begun to answer questions about Ro's function when their earlier experiments demonstrated that the Ro protein binds to small RNA molecules that are misfolded versions of those that help make up the cell's ribosomes, which are its protein assembly lines.

The exact function of the toxin in the iris flower is still unknown, but scientists believe it contains ribosome inactivating proteins (RIPs) that interfere with RNA and protein synthesis.