Although Barna's idea of diverse
ribosomes goes against the classical textbook view, «the concept is not heretical at all,» says Vassie Ware, a molecular cell biologist at Lehigh University in Bethlehem, Pa., not involved in the work.
If
the ribosome goes wrong the cell dies, so its blueprint is highly protected.
Not exact matches
The 2009 Nobel Prize in Chemistry
goes to Venkatraman Ramakrishnan, Thomas Steitz and Ada Yonath for studies of the protein - manufacturing
ribosome, with implications for antibiotic development.
That was surprising, he explains, because «fibrillarin resides deep within the nucleolus of the host cell... [where it] methylates ribosomal RNA molecules, which then
go on to form
ribosomes,» but its full function may not be completely understood.
And in fact it very well might be that once the
ribosomes cease functioning properly, then anything can cause bees to
go under.»
If the yeast's
ribosomes jammed on the oxidized mRNA but were rescued by no -
go decay, very little damaged mRNA would accumulate in the cell.
«You get this small product that is telling you the
ribosome can not
go through the 8 - oxo - G and then you get even smaller products that are telling you there are multiple
ribosomes stuck behind the first
ribosome.
«You'll see that the guy
goes into the middle of the
ribosome, and suddenly up comes a puff of smoke,» says Berg.
A key component in the translation process is the
ribosome, which migrates along the single stranded mRNA, reading the codons as it
goes.
Evgeny Sogorin of the Institute of Protein Research in Moscow and his dancing
ribosomes won in the chemistry category and the People's Choice Award
went to Emmanuelle Alaluf at the Free University of Brussels for a video on the use of an enzyme to improve anti-tumor immune response.
One of the winners of this year's Nobel Prize in Chemistry describes the efforts that
went into piercing the
ribosome's secrets
The
ribosome then ejects the «empty» tRNA molecule so it can
go get another amino acid of the correct type.