Sentences with phrase «ribosomes stalled»

Bacterial ribosomes stalled on defective messenger RNAs (mRNAs) are rescued by tmRNA, an ∼ 300 - nucleotide - long molecule that functions as both transfer RNA (tRNA) and mRNA.

Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during translation of the upstream TnaC leader peptide, a process for which interactions between the TnaC nascent chain and the ribosomal exit tunnel are critical.

We determined a 5.8 angstrom — resolution cryo — electron microscopy and single - particle reconstruction of a ribosome stalled during translation of the tnaC leader gene.

Not exact matches

Proteins are produced by ribosomes, and misfolding can occur if they stall while decoding a damaged template.

Too much structure could force the ribosome to do extra work untangling the strand or even stall translation altogether.

One of the defects is an error in mouse t - RNA (another type of RNA involved in translation) that stalls the ribosome and the other is a defect in the system that rescues the ribosome when it stalls.

When the drug is present, it binds within the tunnel of the ribosome and interacts with the translating leader peptide to stall protein synthesis.

Using cryo - electron microscopy to study the structure of such ribosome - mRNA complexes, the researchers were able to show the manner in which special rescue proteins (Dom34 and Hbs1) recognize such stalled ribosomes, thereby initiating the splitting of the arrested complex and the degradation of the faulty mRNA.