Sentences with word «riboswitch»

In the study, which was published in the journal Nucleic Acids Research, the biologists utilised so - called riboswitches, also called RNA switches, and RNA thermometers.

For her thesis, the PhD student utilised various riboswitches that she coupled in series to a RNA thermometer.

Riboswitches detect if there is a surplus of a certain metabolic product in the cell, and they regulate the biosynthesis or intake of that substance, if necessary.

In transcriptional riboswitches, these different structures signal the nearby RNA polymerase to continue producing RNA or to stop.

In their recent publication in eLife, the Schwalbe group and their collaborators released molecular structures of the xpt - pbuX riboswitch in the off - position after synthesis and in the on - position upon binding by the small messenger molecule guanine.

Unlike the previous seven (those unsolved mysteries from the past), the new riboswitch is also a ribozyme, a scissors - like molecule that can cut up RNA and uses this ability to control gene expression.

At the meeting, Breaker reported on his eighth bacterial riboswitch, which will appear in Nature.

Still, it's clear that «bacteria are loaded» with riboswitches, says Breaker.

Dr. Pillai joined City of Hope as Postdoctoral Fellow in the Department of Molecular and Cellular Bilolgy, where he developed novel genomic methods to regulate alternative splicing using artificial riboswitch.

These also include riboswitches» «RNA molecules, transcription factors and proteins — that can alter gene activity.

Molecular biologist Ronald Breaker of Yale University and his colleagues unearthed these multitalented RNA molecules — a class he calls riboswitches — after wading through decades of scientific literature and puzzling over a handful of unsolved mysteries.

Following an alternative strategy, she integrated the thermometer structure in the riboswitch.

The riboswitch required, for example, a certain chemical substance in combination with a certain temperature.

After producing the xpt - pbuX switch, the RNA polymerase encounters this «pause site» on the DNA code and slows down, allowing the right amount of time for the riboswitch to refold.

As RNA polymerase flies along a DNA strand, producing the corresponding RNA, it reaches the code for the xpt - pbuX switch, makes the riboswitch, and continues on.

After over 10 years of research, Prof. Harald Schwalbe's research group at the Goethe University, in collaboration with the Landick group at the University of Wisconsin, Prof. Jens Wöhnert from Goethe - University's Biology Department and the Süß group at the Technische Universität Darmstadt, has put together the puzzle pieces of a riboswitch - based regulatory process in the bacterium Bacillus subtilis, presenting the most extensive model of the timing of riboswitch action to date.

A riboswitch is a short piece of RNA that can fold into different structures, depending on whether or not a small messenger molecule is binds to it.

However, if guanine were to bind the riboswitch, the riboswitch would need to refold into the on - position, and RNA polymerase would have to wait long enough to detect the new conformation.

These «riboswitches,» as Breaker calls them, are apparently essential to the workings of the cell.

One such regulatory element, the riboswitch, has excited interest as a potential target for antibiotics.

Riboswitches — so named because they meddle with the ribosome — are portions of specific mRNAs that bind to a metabolite.

The first of the three genes showed high level of TPM in the riboswitch and in the coding sequence (Table 5).