Sentences with word «rifampicin»

Drobniewski's team found such mutations in more than 400 isolates that were resistant to the first - line antibiotic rifampicin, and the authors suggest that the mutations might overcome the growth - slowing effect of evolving resistance.

«The approach we're using should be able to create one or more analogs that could help take the place of rifampicin in TB therapy.»

When exposed to the front - line TB drug rifampicin, for example, Mtb cells lacking lamA were less able to survive than wildtype bacteria.

The enzyme, Rifampicin monooxygenase, is a flavoenzyme — a family of enzymes that catalyze chemical reactions that are essential for microbial survival.

The test runs on the GeneXpert system, which uses real - time polymerase chain reaction to rapidly detect MTB and rifampicin resistance, identifying patients infected with drug - resistant strains.

The findings, reported in the Journal of Biological Chemistry, indicate that a new compound, 24 - desmethylrifampicin, has much better antibacterial activity than rifampicin against multi-drug-resistant strains of the bacteria that cause tuberculosis.

Rifampicin susceptible bacteria were small and at the beginning stages of their cell cycles, or larger and at the end stages of their cell cycles.

In the current study, the team found that these longer bacteria were least affected by rifampicin.

A popular antibiotic called rifampicin, used to treat tuberculosis, leprosy, and Legionnaire's disease, is becoming less effective as the bacteria that cause the diseases develop more resistance.

«Our studies have shown how this enzyme deactivates rifampicin.

The anti-angiogenesis drugs also increased the effectiveness of rifampicin, a first - line TB therapy.

It also managed to knock out persister cells in a bacterial biofilm that had already been treated with the antibiotic rifampicin, often used to fight persistent infections at the site of prostheses.

The study followed 1,055 household contacts of 213 individuals with MDRTB infection (defined by resistance to the drugs rifampicin and isoniazid), and 2,362 household contacts of 487 individuals with drug - susceptible tuberculosis for up to three years.

Vitamin C had no activity by itself, but in two independent experiments, the combination of vitamin C with the first - line TB drugs, isoniazid and rifampicin, reduced the organ burdens faster than the two drugs without vitamin C, said first author Catherine J. Vilcheze, Ph.D..

«Thus in our new paper, we postulate that vitamin C is stimulating respiration of the Mtb cells in mice, thus enabling the action of isoniazid and rifampicin.»

To determine whether gut microbes could affect an organism's longevity and its ability to reproduce, Vanderbilt University geneticist Seth Bordenstein and his colleagues dosed the termites Zootermopsis angusticollis and Reticulitermes flavipes with the antibiotic rifampicin.

Efforts to control tuberculosis are being hampered by the emergence of multidrug - resistant (MDR) strains of the disease, which resist treatment with two front - line antibiotics, rifampicin and isoniazid.

But two forms of tuberculosis, referred to as «multi-drug-resistant,» or MDR, and «extensively drug - resistant,» or XDR, have become resistant to rifampicin.

Rifampicin and related drugs are important antibiotics, the key to an effective «drug cocktail» that already takes about six months of treatment to cure tuberculosis, even if everything goes well.

«Rifampicin is the most effective drug against tuberculosis, and it's very difficult to achieve a cure without it,» Mahmud said.

Drug resistance in rifampicin and related antibiotics has occurred when their bacterial RNA polymerase enzymes mutate, Mahmud said, leaving them largely unaffected by antibiotics that work by inhibiting RNA synthesis.

One of the mechanisms leading to rifampicin's resistance is the action of the enzyme Rifampicin monooxygenase.

Rifampicin, also known as Rifampin, has been used to treat bacterial infections for more than 40 years.

Approximately 1 in 5 cases of TB are now resistant to at least one major anti-TB drug and approximately 5 % of all cases of TB are classed as MDR (resistant to two essential first - line TB drugs, isoniazid and rifampicin) or XDR (also resistant to fluoroquinolones and second - line injectable drugs).

They studied the proteomic responses of the bacteria to five compounds — isoniazid, rifampicin, moxifloxacin, mefloquine and bedaquiline — and discovered escape pathways and enzymes associated with changes in metabolic state.

The researchers were able to analyze the responses of individual bacteria to rifampicin, a core frontline antibiotic used to treat tuberculosis.

The intensive treatment for pulmonary TB is a six - month regime that consists of two months of isoniazid, rifampicin, pyrazinamide, and ethambutol, followed by four months of isoniazid and rifampicin in FDCs that are combined in one tablet, or separately as single - drug formulations.

Evaluation of the GenoType MTBDRplus assay for detection of rifampicin - and isoniazid - resistant Mycobacterium tuberculosis isolates in central Ethiopia.

Drugs suspected of having similar capacity to reduce plasma levels of levonorgestrel include barbiturates (including primidone), phenytoin, carbamazepine, herbal medicines containing Hypericum perforatum (St. John's Wort), rifampicin, ritonavir, rifabutin, and griseofulvin.