For us to be healthy, these choices need to ensure we get
the right number of each cell type.
Tips: Göttgens suggests working with a bioinformatician to design the experiment from the outset to power the study with
the right number of cells and to limit the potential influence of batch effects (in which two results differ because they were collected on different days).
«You might have
the right number of cells, but the cells might not grow in size.
That's why we think that the problems these kids have are more in the connections their cells make than in actually getting
the right number of cells in the first place,» he says.
Not exact matches
One particularly interesting use
of cell phones for fundraising in the 2008 election cycle: the John Edwards campaign contacted list members via text, urged them to call a
number and listen to a recorded message, then connected them to operators to take donations
right away.
STOP SIGNS Brainlike structures grown from autistic patients» stem
cells (
right) produced greater
numbers of brain
cells that make other brain
cells less active (green and red) compared with structures grown from the
cells of a non-autistic family member (left).
Compared to a control (left), epalrestat treatment (
right) reduces the
number of metastatic tumors (arrowheads) in the lungs
of mice injected with human basal - like breast cancer
cells.
Numbers of migrating
cells, shown in red, are greatly reduced when the molecule FOX01 is deleted (
right column).
Right under our noses the patient had lost the
number of red
cells contained in almost a quart
of blood — and nobody had the faintest clue why.
On a molecular level this process is controlled by a wide range
of factors, ensuring that the
right number of undifferentiated progenitor
cells differentiate into skin
cells and make their way to replace the old damaged ones.
Much like thermostats that adjust the temperature in a room to make sure it's not too hot or too cold, kinases make sure that the
right number of new
cells are created as old ones die.
The BUB1B gene encodes a protein that helps guarantee that the
right number of chromosomes are passed from
cell to
cell.
Something in the
cell was inhibiting the trigger at other time points, ensuring the
right copy
number of centrioles was formed at the
right time,» says Zitouni Sihem, co-first author
of this study.
But how do mother
cells know they provide the
right number of centrioles to their daughters?
Mónica Bettencourt - Dias adds: «I am very proud
of this paper, we knew the
cell cycle clock and centriole formation had to be linked - otherwise how would
cells ensure the
right copy
number is made?
To achieve this that fate
of these
cells must be precisely regulated, such that the
right number and type
of cells is created at a given time and point in development.
The technical evaluation
of projects may require the provision
of additional data such as information on the genetic modification
of your mutant mouse line if applicable (e.g. affected gene, MGI ID
of the gene, type
of mutation, ES -
cell line used, genetic background (e.g.
number of backcross generations), safety level, description
of DNA modification, vector, remaining non-recipient DNA, donor organism), mutant phenotype (s), special housing or care requirements, current sanitary status, and intellectual property
rights (who generated the mouse line, owner
of the mouse line)
Number one, if someone's going to radiation treatment, radiation treatment is essentially a corporate bomb
of all
cells,
right?
And make sure you've programmed your Vet's phone
number into your
cell phone in case you need to reach him
right away because
of an emergency situation.