Sentences with phrase «risk alleles in»

Researchers at the Fred Hutchinson Cancer Research Center have identified three risk alleles in three different genes associated with GDV in Great Danes.

One approach, developed largely in collaboration with Dr. Elaine Ostrander at the National Human Genome Research Institute of the National Institutes of Health and Dr. Kerstin Lindblad - Toh at the Broad Institute of MIT and Harvard, seeks to map risk alleles in Portuguese Water Dogs, Golden Retrievers, and German Shepherds using resources made available by the recent completion of the Canine Genome Project.

OptiGen is able to provide updates on the actual frequency of the risk allele in the population as more widespread testing of the breed occurs.

Not exact matches

In some cases, we can actually trace that increased risk to actual alleles that segregate at different frequencies in different populations (eg., diabetes in Native American populationsIn some cases, we can actually trace that increased risk to actual alleles that segregate at different frequencies in different populations (eg., diabetes in Native American populationsin different populations (eg., diabetes in Native American populationsin Native American populations).

Additional analysis of UK Biobank data from 112,338 people of European ancestry revealed that a specific form of rs9349379 known as the G allele, which was present in 36 % of these individuals, was associated with an increased risk of coronary artery disease.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

Women with two copies of s fared even worse: They had bones that were 4 % less dense — and faced a 280 % higher risk of fracture — than did women without any s alleles, says team member Andre Uitterlinden, a molecular geneticist at Erasmus University in Rotterdam, the Netherlands.

«Carriers of this allele had a roughly 2-fold increase in risk for PTSD.»

The research by scientists at Children's Hospital Los Angeles and Columbia University shows a link between a particular allele for serotonin found at a higher frequency in those at risk of depression because of family history, and those who go on to develop major depressive disorder.

Having this allele reduces the risk of severe malaria by about 40 % in Kenyan children, with a slightly smaller effect across all the other populations studied.

The grey matter volume in the left middle temporal gyrus was smaller in schizophrenia patients harboring risk homozygous T / T alleles.

As a genetic explorer Peltonen has followed the movement of populations in history, knowing that genes had diversified during the moves, but in Finland as elsewhere only a tiny fraction of the alleles and health risks are distinctive.

40 individuals (22.9 %) had at least one ε4 allele and were considered «at risk» for AD, 111 (63.4 %) had the ε3 / ε3 genotype and were considered «neutral,» and 24 (13.7 %) in the «protective: group had at least one ε2 allele.

In addition, in two of the datasets where researchers had age - of - onset data for age - related diseases, they found that certain longevity alleles also were significantly associated with reduced risks for cardiovascular disease and hypertensioIn addition, in two of the datasets where researchers had age - of - onset data for age - related diseases, they found that certain longevity alleles also were significantly associated with reduced risks for cardiovascular disease and hypertensioin two of the datasets where researchers had age - of - onset data for age - related diseases, they found that certain longevity alleles also were significantly associated with reduced risks for cardiovascular disease and hypertension.

A new study published in the current issue of Biological Psychiatry suggests that even when controlling for the risk for Alzheimer's disease, the APOE ε4 allele also conveys an increased risk for late - life depression.

Given that two separate teams found evidence for the same variant in a large number of sick people, «one can be absolutely confident that this risk allele is real,» says McPherson.

«Careful analysis of the total number of repeats, the number of interruptions in the repeat tract, and the methylation status of the FMR1 gene is important for a proper understanding of an individual's risk of transmission of larger alleles to their offspring and to their personal risk of disease pathology.

Intermediate alleles are thought to be at risk of expanding in the offspring of people who carry them.

Mostly, I was interested in two things: BRCA1 / 2 mutations and APOE4 alleles, well - established risk variants for cancer and Alzheimer's disease, respectively.

DONG ET AL.The allele apolipoprotein E ε4 (APOE ε4) is the greatest genetic risk factor for Alzheimer's disease (AD), but the role of the ApoE4 protein in AD has long been elusive.

Furthermore, sex - specific differences in gene polymorphism are suggested by one study showing that diabetic women carrying ACE D allele have a higher risk for development of diabetic nephropathy, which was not seen in diabetic men (Table 2)(331).

Performing genetic studies in multiple human populations can identify disease risk alleles that are common in one population but rare in others, with the potential to illuminate pathophysiology, health disparities, and the population genetic origins of disease alleles.

Published in the European Journal of Cancer Galore - Haskel G, Azizi E, Mohamdi H, Scope A, Chaudru V, Laitman Y, Barak F, Pavlotsky F, Demenais F, Friedman E. MC1R variant alleles and malignant melanoma risk in Israel.

We found a significant association between rs10524523 and risk of LOAD in APOE 33 homozygotes but in the opposite direction as the previously reported association (the very long allele was underrepresented in cases vs controls in this study (P =.004]-RRB-.

Use of common risk alleles for changes in clinical management can be challenging without a professional guideline.

In contrast, more than 70 other common alleles have been associated with breast cancer susceptibility, most of which confer only a mild to moderate increase in risIn contrast, more than 70 other common alleles have been associated with breast cancer susceptibility, most of which confer only a mild to moderate increase in risin risk.

Common risk alleles with a known association with a condition can inform an individual of an increased or decreased risk of developing the condition in question; however, the degree of certainty is often unknown.

In addition, the clinical sensitivity of tests for common risk alleles is not necessarily high.

However, in subgroup analyses stratified by age, we found that the deletion allele was associated with increased risk for lung cancer among individuals < 50 years of age (OR 2.17, CI 1.19 - 3.97), and that the association was gradually reduced with increasing age (p = 0.01).

Polymorphisms in five of 15 genes (33 %) encoding molecules known to primarily influence pancreatic beta - cell function - ABCC8 (sulphonylurea receptor), KCNJ11 (KIR6.2), SLC2A2 (GLUT2), HNF4A (HNF4alpha), and INS (insulin)- significantly altered disease risk, and in three genes, the risk allele, haplotype, or both had a biologically consistent effect on a relevant physiological trait in the QT study.

We imputed these variants into 104,220 individuals down to a minor allele frequency of 0.1 % and found a recessive frameshift mutation in MYL4 that causes early - onset atrial fibrillation, several mutations in ABCB4 that increase risk of liver diseases and an intronic variant in GNAS associating with increased thyroid - stimulating hormone levels when maternally inherited.

The two most striking risk factors appear to be hyperinsulinism and possession of one or two E4 alleles for the apolipoprotein E gene (ApoE4), which is involved in lipid processing.

15 In fact, type 2 diabetes (T2D)-- a condition stemming from broken glucose metabolism and insulin signaling — has been identified as an additional risk factor for developing AD.16, 17 Moreover, the pathological changes that occur in AD in the brain physically resemble those seen in the pancreas and vasculature in T2D.9, 18 Type 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key factoIn fact, type 2 diabetes (T2D)-- a condition stemming from broken glucose metabolism and insulin signaling — has been identified as an additional risk factor for developing AD.16, 17 Moreover, the pathological changes that occur in AD in the brain physically resemble those seen in the pancreas and vasculature in T2D.9, 18 Type 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key factoin AD in the brain physically resemble those seen in the pancreas and vasculature in T2D.9, 18 Type 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key factoin the brain physically resemble those seen in the pancreas and vasculature in T2D.9, 18 Type 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key factoin the pancreas and vasculature in T2D.9, 18 Type 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key factoin T2D.9, 18 Type 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key factor.

It has been suggested that the positive associations reported in case - control studies may have resulted from recall bias or confounding by factors such as smoking.19, 34 However, because we observed an association between coffee and risk of MI among carriers of the * 1F allele, and not among those homozygous for the * 1A allele, the associations between coffee and MI are unlikely due to recall bias or residual confounding.

Advice on how to make best use of the DNA test for IG - PRA1 needs to account for the possibility that the disease may be inherited in an ADIP manner and that the presence of a single copy of the risk allele may cause PRA in some Italian Greyhounds.

It must be noted however that a subset of PRA - affected Italian Greyhounds in the study carried only one copy of the IG - PRA1 risk allele, suggesting that the disease may represent a mode of inheritance called «Autosomal Dominant with Incomplete Penetrance» (ADIP).

All Italian Greyhounds that were homozygous for the IG - PRA1 risk allele were diagnosed with PRA and two copies of the risk allele were never observed in any Italian Greyhounds with normal eye exams (at the risk age or older).

At least one other form of PRA that is not associated with the IG - PRA1 risk allele is present in the Italian Greyhound.

The majority of dogs in the research that carried only one copy of the risk allele did not develop PRA.

While Sentinel is safe to use in dogs at risk for MDRI - allele mutation (Australian Shepherds, Collies, Shelties, etc.), unless tested normal, caution is advised if your pet is also being given amiodarone (Cordarone), azole antifungals such as ketoconazole, carvedilol (Coreg), cyclosporine (Atopica), diltiazem (Cardizem), erythromycin (Ery - Tabs) or clarithromycin (Biaxin), quinidine, spironolactone (Aldactone), tamoxifen, and verapamil (Calan).

For each of the three genes, one allele (variant) is found at unusually high frequency in dogs that have been treated for bloat, and the presence of any one of these «risk» alleles triples the chance that the dog will experience bloat at some time in its life.

The team will investigate whether bloat in German Shepherd Dogs is associated with the same risk alleles and the same microbiome profiles as were seen in Great Danes.

However, caution should be used in aggressively selecting against mutant alleles which have low penetrance or low risk for the disease state when the mutant alleles are common throughout the breed.

Specific assortments of MHC alleles or haplotypes have been associated with an increased risk for the development of diabetes and auto immune diseases in humans.

Moreover, overrepresentation of a popular sire's genome risks the widespread dissemination of monogenetic inherited disorders by inflating the allele frequency of recessive deleterious variants carried by the sire and increasing the probability of identity by descent of undesirable alleles in his descendants [18,20,21].

The test identifies seven mutations in three different genes which permits identification of the «risk alleles,» which are not causative of GDV but are highly associated.

Review: apolipoprotein E ε4 allele is a risk factor for Alzheimer's disease in different ethnic groups

In this study, measures of the quality and availability of social supports were found to moderate risk for depression associated with a history of maltreatment and the presence of the short (s) allele of the serotonin transporter gene promoter polymorphism (5 - HTTLPR).

In the absence of these experiences, the s allele was not associated with an increased risk for psychopathology.

The associated alleles were common in the studied populations and all had only small effects on disease risk [123].