Sentences with phrase «risk gene variants»

Several genes influence a person's likelihood of developing fatty liver disease, but a recent study in Nature Genetics found that people with high - risk gene variants were much more likely to actually get the disease if they were obese than if they were normal weight.

Carriers of risk gene variants are more prone to dopaminergic mental illness.

The Vienna research group, together with international cooperation partners, have demonstrated that there are interactions between stressful life events and certain risk gene variants that subsequently change the volume of the hippocampus forever.

Those differences led to lower levels of the IFITM3 protein in ndividuals with two copies of the high - risk gene variant compared to other patients, researchers said.

Among the Japanese participants, the risk gene variant had a similar frequency in centenarians (46.4 %) and in healthy controls (47.3 %), but it was less frequent than in controls performed with cardiovascular disease (57.2 %).

The exact biological explanation is not yet clear; however, she says one possibility is that people with the high - risk gene variant have an insulin - production system that is overly sensitive to melatonin.

Not exact matches

The company will now be able to sell health risk reports on three variants found on the BRCA1 and BRCA2 genes, which are linked with a higher risk of breast, ovarian, and prostate cancer.

Collaboration based on new findings from the Regeneron Genetics Center ® showing variant in HSD17B13 gene is associated with reduced risk of chronic liver diseases

For those who have MTHFR gene variants, supplemental folic acid has not been found to reduce the risk of miscarriage.

These SCARB1 gene variant studies aren't the only ones to challenge the long - held belief that increasing HDL was the key to reducing heart disease risk.

Many of these risk variants localize inside or close to genes that regulate the vascular system.

Among the DNA variants known to cause Alzheimer's or increase risk of the disease, none are found in the tau gene.

We used the LD signal strength as a guide to find our way to the true risk gene — the particular variant that actually caused the increased risk for lupus.»

«So a [gene variant] that conferred risk to asthma confers protection against [worm infection].»

Dr Antonio Pardiñas, first author of the study, said: «We show for the first time that genetic variants that do not severely impact gene function, but presumably have a more subtle impact on these critical genes, increase risk for developing schizophrenia.»

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

Although individuals with variants in their FTO gene have almost double the risk of obesity compared with those who do not inherit the gene, «having the FTO variant doesn't mean one is destined to be fat.

The team also examined data from a prior genetic study of children with asthma and found that a variant of the dectin - 1 gene — which reduces production of the receptor — is strongly linked to increased asthma risk.

Certain gene variants are associated with an increased risk of disease, but MS is rarely directly inherited.

«In the current study, we analyzed dozens of variants of those genes and other genes frequently associated with obesity risk and saw that, while total fat intake was related to higher BMI, people who were genetically predisposed to obesity and ate the most saturated fat had the highest BMIs.»

Alzheimer's - Of the three variants of the ApoE gene, ApoE4 carries the highest risk for late - onset Alzheimer's (other genes are associated with early - onset Alzheimer's).

Large - scale genomic studies will probably uncover more gene variants associated with increased risk of developing PTSD, says de Quervain, and may provide a better understanding of the molecular mechanisms involved.

The group has also shown that in humans, genetic variants of the Oprl1 gene are associated with higher risk of developing the disorder after exposure to trauma.

Gene variants have been linked to elevated risks for disorders from Alzheimer's disease to breast cancer, and they may help explain why, for example, some smokers develop lung cancer whereas many others don't.

They found that people with the gene variant had the highest risk of side effects when they were given a statin called simvastatin, but this risk was much lower when they took pravastatin.

«Gene variant explains racial disparities in adverse reactions to urate - lowering drug: Findings support screening for risk - associated variant in Asian, black patients with gout.»

More than one quarter of children with two copies of a high - risk variant in a specific group of genes develop an early sign of celiac disease called celiac disease autoimmunity (CDA) by age 5.

The increased risk closely correlates with the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations.

Scientists also know dozens of gene variants that increase people's risk of lupus.

For example, researchers reported in a much touted 2006 Science article that they had discovered a gene variant that seemed to confer a risk for obesity, and they replicated the results in four human populations.

Professor Peter Kraft at Harvard TH Chan School of Public Health, USA, says: «Given the size of these studies, we expected that we would find a lot of new breast cancer risk variants, but the studies tells us a lot more about which genes are involved, revealing many previously unsuspected genes and genetic mechanisms underlying breast carcinogenesis.

The inherited component of breast cancer risk is due to a combination of rare variants in genes such as BRCA1 and BRCA2 that confer a high risk of the disease, and many commoner genetic variants that each confer only a small risk.

By characterising the DNA sequence of these individuals, the project gained insight into the contribution of rare variants to a broad range of disease scenarios, and discovered new genetic variants and genes underpinning disease risk.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

«A new blue gene: NKPD1 variant increases depression risk.»

«We are the first to show a possible genetic connection in this respect,» said Dr. Amin, adding that this implies that such a therapy might be beneficial for patients carrying risk variants in the NKPD1 gene.

Carrying a particular version of the gene for apolipoprotein E (APOE) is the major known genetic risk factor for the sporadic, late - onset form of Alzheimer's disease, but exactly how that variant confers increased risk has been controversial among researchers.

A special gene variant increases the risk of heavy smoking.

This year, however, researchers linked variants of more than 50 genes to increased risk for a dozen diseases.

Three simultaneous reports involving more than 32,000 participants uncovered four new diabetes - associated gene variants, bringing to 10 the number of known non-Mendelian genetic risk factors for type 2 diabetes.

Common gene variants that have minor effects may contribute about half the risk of developing autism

The new study focused on 40 cognitively healthy older adults between the ages of 65 and 75 who are carriers of a gene variant (APOE e4) that is known to contribute to the risk of developing late - onset Alzheimer's disease.

People who have one copy of the APOE gene variant e4 have a three times greater risk of developing AD.

That group also concluded that the increased risk of sepsis caused the defective variant to replace the original gene.

Hereditary predisposition to cancer is sometimes due to a single high - risk genetic change, like a mutation in the BRCA1 or BRCA2 genes for breast cancer, but most of the time, the disease is the result of multiple gene variants that add up, environmental risk factors, and a big element of chance.

In fact, in another study published last year, National Institute on Aging (NIA) researchers discovered that people with what's called a CR1 gene variant — the presence of which heightens Alzheimer's disease risk — had much lower levels of amyloid protein compared with those without the mutant gene.

Evidence for ADGRL3 in ADHD risk had already been stacked against it — common variants of the gene predispose people to ADHD and predict severity of the disorder.

The gene variants that have been identified so far contribute only weakly to the risk of contracting the disorder.

• SCT conferred a similar degree of risk as APOL1 gene variants, which are the most widely recognized genetic contributors to kidney disease in blacks.

However, the researchers found that a variation of ECR47 associated with ADHD disrupted ECR47's ability to bind an important neurodevelopmental transcription factor, YY1 — an indication that the risk variant interferes with gene transcription.