Sentences with phrase «risk haplotype»
A "risk haplotype" refers to a specific combination of genes that increases the probability of developing a certain disease or condition. It means having certain genetic variations that make a person more susceptible to the risk of that particular health issue. Full definition
The deCODE team, working with clinicians and researchers at Iceland's National University Hospital and the Icelandic Heart Association, identified the at - risk haplotype through the analysis of detailed genotypic data from several thousand patients and unaffected relatives in Iceland participating in the company's cardiovascular disease programs.
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MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels.
The genes were identified through population - and genome - wide linkage scans and association analyses of at - risk haplotypes utilizing genetic and clinical data from the 17,000 participants in deCODE's obesity program in Iceland.
But while these known inherited risk haplotypes convey a significant percentage (~ 20 %) of the risk of hemangiosarcoma and lymphoma, it is likely that there are additional genetic risk factors too.
By comparing the haplotypes, Kere's team uncovered two genes with mutations unique to the high - risk haplotypes.
This analysis showed differential expression associated with the haplotypes at both loci, suggesting the risk haplotypes are associated with an effect on T - cell response.
The risk haplotype carries four amino acid substitutions, all in SLC16A11; it is present at ~ 50 % frequency in Native American samples and ~ 10 % in east Asian, but is rare in European and African samples.
Analysis of an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals.
Identification of a novel neuregulin 1 at - risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic / Scottish risk haplotype.
The at - risk haplotypes, or versions of the gene linked to obesity, were found in more than one in four individuals with high BMI, and were three times more common in these individuals than in controls.
It was found that these risk haplotypes regulate genes involved in immune response, and this may be the reason that risk for both hemangiosarcoma and lymphoma is elevated in dogs that carry them.
The odds ratio of dogs with a risk haplotype being aggressive to humans compared with those having a protective haplotype varied from 4.4 to 9.0.
Another important factor in reading and writing disabilities, READ1, a polymorphic compound with a short tandem repeat within intron 2 of risk gene DCDC2 may have a non-additive genetic interaction with KIAHap, a risk haplotype in risk gene KIAA0319 may be a transcriptional regulator of ETV and so also a transcriptional regulator of KIAA0319.