Sentences with phrase «risk in human patients»

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

Not exact matches

A general summary was provided by ethics experts who testified before then - Congressman Albert Gore's Committee on Science and Technology in 1982: (1) Though risks in experimentation are inevitable, a strong bias toward the sacredness of human life requires the highest regard for the patient or subject.

The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000 human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with the way the brain regulates connections between neurons.

Though the findings were made in mice, not humans, the researchers say the crucial role of calcium may help explain another mystery: Why some hospital patients and nursing home residents have a much higher risk of contracting C. diff infections and the resulting diarrhea that carries its spores out of the body.

«More research is needed to evaluate the efficacy of this use of a cancer medication to alleviate risk of sudden cardiac death, but we are hopeful that what we observed in mice will translate effectively to humans, providing patients and clinicians with a new paradigm for treating this common and life - threatening illness,» Dudley said.

BOSTON — A heated discussion broke out here today at the annual meeting of the American Society of Human Genetics over a hot - button topic: When will we know enough about rare cancer risk genes to begin routinely testing for them in patients with a family history of cancer?

Secondly, before considering the use of iPSC - derived organoids for transplantation / regenerative medicine in human patients, the current protocols for expansion, reprogramming and differentiation of iPSCs in long - term cultures need further improvement to minimize the risk of oncogenic cellular mutations and teratoma, or tumor formation, in the patient.

Carlos is a neuroscientist whose academic work has primarily focused on developing novel human MRI methods to evaluate disease progression and incident risk in stroke and neurodegenerative disease patients.

Infected patients are at - risk for long - term joint stiffness and pain, which increases the need to better understand the sequence diversity of these viruses and how any viral mutations affect the severity of disease in the human host.

In the genome - wide association study (GWAS) published in Nature, the authors looked at over 80,000 genetic samples from schizophrenia patients and healthy volunteers and found 108 specific locations in the human genome associated with risk for schizophreniIn the genome - wide association study (GWAS) published in Nature, the authors looked at over 80,000 genetic samples from schizophrenia patients and healthy volunteers and found 108 specific locations in the human genome associated with risk for schizophreniin Nature, the authors looked at over 80,000 genetic samples from schizophrenia patients and healthy volunteers and found 108 specific locations in the human genome associated with risk for schizophreniin the human genome associated with risk for schizophrenia.

Elevated plasma TG levels represent a risk factor for CVD in humans, and an adjusted analysis of patients in the Framingham Heart Study suggests that each decrease of 1 mg / dl in plasma ApoC - III levels is associated with a 4 % decrease in CVD risk (11), further supporting the potential therapeutic benefit of suppressing plasma ApoC - III levels in humans to reduce CVD.

Objectives: The study goal was to leverage 3 distinct lines of evidence - a family that included individuals with complete (compound heterozygote) ANGPTL3 deficiency, a population based - study of humans with partial (heterozygote) ANGPTL3 deficiency, and biomarker levels in patients with myocardial infarction (MI)- to test whether ANGPTL3 deficiency is associated with lower risk for CAD.

In support of this concept, we have shown that mtDNA mutations accumulate in proportion to life span in several animals, that increasing mitochondrial anti-oxidant defense systems extends lifespan, that ancient human mtDNA variants that modify energy production and oxygen radical production can modulate longevity and risk for neurodegenerative diseases, and that patients with the neurodegenerative disease, Alzheimer Disease, have increased mtDNA mutationIn support of this concept, we have shown that mtDNA mutations accumulate in proportion to life span in several animals, that increasing mitochondrial anti-oxidant defense systems extends lifespan, that ancient human mtDNA variants that modify energy production and oxygen radical production can modulate longevity and risk for neurodegenerative diseases, and that patients with the neurodegenerative disease, Alzheimer Disease, have increased mtDNA mutationin proportion to life span in several animals, that increasing mitochondrial anti-oxidant defense systems extends lifespan, that ancient human mtDNA variants that modify energy production and oxygen radical production can modulate longevity and risk for neurodegenerative diseases, and that patients with the neurodegenerative disease, Alzheimer Disease, have increased mtDNA mutationin several animals, that increasing mitochondrial anti-oxidant defense systems extends lifespan, that ancient human mtDNA variants that modify energy production and oxygen radical production can modulate longevity and risk for neurodegenerative diseases, and that patients with the neurodegenerative disease, Alzheimer Disease, have increased mtDNA mutations.

In the meantime, the results of experiments in animals and humans suggest that lipid - lowering drug treatment, especially with the fibrates and statins, should be avoided except in patients at high short - term risk of coronary heart diseasIn the meantime, the results of experiments in animals and humans suggest that lipid - lowering drug treatment, especially with the fibrates and statins, should be avoided except in patients at high short - term risk of coronary heart diseasin animals and humans suggest that lipid - lowering drug treatment, especially with the fibrates and statins, should be avoided except in patients at high short - term risk of coronary heart diseasin patients at high short - term risk of coronary heart disease.

Mycotoxin exposure can cause mild inflammation in every human being, but sensitive acne patients are particularly at risk.

CHAPTER 1 Indications, Screening, and Contraindications Associated with Bariatric Surgeries Obesity Trends and Consequences Criteria for Bariatric Surgery in Adults Contraindications to Bariatric Surgery CHAPTER 2 Types and History of Bariatric Surgery Broad Categories of Bariatric Procedures History and Time - line of Bariatric Surgery Procedures Restrictive - Malabsorptive Surgery: Roux - en Y Gastric Bypass Purely Restrictive Bariatric Procedures Purely Malabsorptive Procedures Experimental or Investigational Procedures CHAPTER 3 Benefits and Risks of Bariatric Surgery Benefits of Bariatric Surgery Complications of Bariatric Surgery Consequences of Surgery Which May Impact Nutritional Status CHAPTER 4 Perioperative Nutrition Recommendations for Bariatric Surgery Patients Multidisciplinary Approach Prior to Surgery Preoperative Nutrition Guidelines Postoperative Nutrition Assessment and Follow - up Diet Progression Recommendations for Adjustable Gastric Band Diet Progression Recommendations for Roux - en Y Gastric Bypass or Sleeve Gastrectomy Diet Progression Recommendations for Biliopancreatic Diversion (BPD) Vitamin and Mineral Supplementation Exercise CHAPTER 5 The Power of Protein: What the Nutrition Professional Should Know Overview Role of Protein in the Body Sources of Protein Digestion and Absorption of Protein Digestion Rate Upper Limits of Protein Digestion Liver Processing and Elimination Protein Requirements in Humans Beneficial Roles of Protein: Muscle Protein Synthesis, Glucose and Lipid Homeostasis, Thermogenesis and Satiety Muscle Protein Synthesis and Maintenance of Lean Body Mass Glucose and Lipid Homeostasis Thermogenesis and Satiety Protein Malnutrition Preoperative Risk of Protein Malnutrition Postoperative Risk of Protein Malnutrition Protein Prescription for the Bariatric Patient Treatment for Protein Malnutrition in the Bariatric Patient The «30 gram» Protein Myth Liquid or Powder Protein Supplements The Patient's Role Conclusions CHAPTER 6 Micronutrient Deficiencies Associated with Bariatric Surgery Overview Water Soluble Vitamins Thiamin: Overview, Food Sources, Digestion and Metabolism Thiamin Deficiency: Signs and Symptoms Thiamin: Assessment and Treatment of Deficiency Vitamin B12: Overview, Food Sources, Digestion and Metabolism Vitamin B12 Deficiency: Signs and Symptoms Vitamin B12: Assessment and Treatment of Deficiency Folate (folic acid): Overview, Food Sources, Digestion and Metabolism Folate Deficiency: Signs and Symptoms Folate: Assessment and Treatment of Deficiency Fat Soluble Vitamins Vitamin A: Overview, Food Sources, Digestion and Metabolism Vitamin A Deficiency: Signs and Symptoms Vitamin A: Assessment and Treatment of Deficiency Vitamin D and Calcium: Overview, Food Sources, Digestion and Metabolism Vitamin D and Calcium Deficiency: Signs and Symptoms Vitamin D and Calcium: Assessment and Treatment of Deficiency Minerals Iron: Overview, Food Sources, Digestion and Metabolism Iron Deficiency: Signs and Symptoms Iron: Assessment and Treatment of Deficiency Zinc: Overview, Food Sources, Digestion and Metabolism Zinc Deficiency: Signs and Symptoms Zinc: Assessment and Treatment of Deficiency Copper: Overview, Food Sources, Digestion and Metabolism Copper Deficiency: Signs and Symptoms Copper: Assessment and Treatment of Deficiency Selenium: Overview, Food Sources, Digestion and Metabolism Selenium Deficiency: Signs and Symptoms Selenium: Assessment and Treatment of Deficiency Conclusions References Abbreviations and Acronyms Glossary Self Assessment Questions Answer Key to Self Assessment Questions Explanations to Self - Assessment Questions About The Author About Wolf Rinke Associates, Inc..

Although anesthesia will never be 100 % risk - free, modern anesthetics (including intravenous fluids and rapidly acting and rapidly metabolized anesthetic drugs) and patient evaluation techniques (ECG, blood pressure, temperature, heart rate, etc) used in advanced veterinary hospitals minimize the risks just like in human medicine.

Just as in human medicine, these risks are extremely low nowadays due to the combination of new and improved anesthetic medications, high - quality monitoring equipment, the use of pre-anesthetic blood testing to diagnose underlying health conditions that may put the patient at higher risk, and ongoing continuing education for doctors and staff.

Job Description: • Represents the Kansas City Pet Project in a professional, polite and enthusiastic manner • Assists the veterinarians on a daily basis with preparing surgery patients, health assessments, and treatments of animals • Assist in medical rounds with Shelter Veterinarians or identifying animals that need to be seen by a Shelter Veterinarian • Administer medications to both cats and dogs in accordance with veterinarian's prescribed doses and ensure all treatment protocols prescribed for sick / injured animals are performed timely, safely, and humanely • Responsible for following best practices for sanitation protocols in all veterinary clinic and isolation areas to reduce / eliminate disease transmission • Input all medical notes, health assessments, vaccinations, surgeries, treatments, etc., into PetPoint • Provides support for other departments, such as Intake, Foster, Placement & Transport, or Adoptions by assisting as needed for vaccinations, deworming, blood draws, etc. • Prepares and sanitizes surgical instruments / packs each day to ensure packs are ready for use the following day • Assists with discharging animals to the public post-surgery or following up with sick pet appointments, explaining any medical issues, medications, after care instructions, etc. • Ensures adequate medical supplies and medications are available and reports any shortages to Vet Clinic Manager • Enforces and maintain KCPP safety and cleanliness, and all health and security rules and procedures • Follows disease prevention procedures and completes cleaning of veterinary clinic areas daily and ongoing throughout the day to decrease biological risks to humans and other animals • Care, feed, and safely handle animals to avoid injury to persons / animals • Properly store and maintain inventory of medical supplies, including Schedule II narcotics • Performs laboratory analysis techniques to assist Shelter Veterinarians • Reads, understand, interpret, and apply department policies and procedures • Prepares reports and other written materials in a logical, concise, and accurate manner • Functions calmly in situations that require a high degree of sensitivity, tact, and diplomacy • Communicates effectively with a variety of individuals representing diverse cultures and backgrounds and function calmly in all situations which require a high degree of sensitivity, tact and diplomacy • Treats employees, representatives of outside agencies, volunteers, and members of the public with courtesy and respect • Provides prompt, efficient and responsive service for all phone calls forwarded to the Vet Clinic.

Synthetic colloids were previously used early and commonly in septic patients Recent evidence in human patients and experimental + / - clinical animal studies suggests negative risk - benefit assessment.

Results driven health and human services expert with distinct analytical skills and a wholly professional approach to evaluating overall effectiveness and providing the crucial decisions that result in smooth, seamless operations; seeks position where working knowledge will be fully utilized and expanded, with particular emphasis on: Managed Care / Health Services Risk Management / Patient Safety Consulting / Advisory Serv...