Not exact matches
APOE4 raises the
risk of Alzheimer's partly by encouraging
amyloid beta to collect into damaging
plaques.
While approximately 80 percent
of Alzheimer's disease patients also have cerebral
amyloid angiopathy, or
amyloid beta deposits in the brain's blood vessels that increase the
risk for stroke and dementia, the predominant
amyloid beta pathology is
plaques.
The gene is also linked to formation
of the
amyloid - beta peptide associated with sticky
plaque, one
of the supposed hallmarks
of the disease, but how ApoE4 actually brings or heightens
risk for the disease is unclear.