There are a few bits of evidence that show
the risk of psoriasis as having a potential connection to abnormal liver functions.
Statistically, cigarette smoking increases
the risk of psoriasis developing in women particularly.
While it's not entirely clear, it's possible that a family history of the disease, as well as lifestyle factors like smoking and obesity, can raise one's
risk of psoriasis.
Previous studies have suggested that IkappaBzeta genetic variations may raise
the risk of psoriasis, so the researchers hypothesized that lowering this protein with itaconate would treat psoriasis.
Not exact matches
Psoriasis and psoriatic arthritis can also place people at
risk of side effects from the long - term use
of medications such as steroids and injectable medications.
Certain biologic (injectable) medications that are commonly used to treat the mother's
psoriasis and PsA place her at an increased
risk of developing infections such as the common cold.
They found patients with a BSA
of two percent or less had a relative
risk of 1.21 for developing diabetes, meaning their
risk is 21 percent higher than those without
psoriasis.
He also says these results add to the growing understanding
of the additional
risks associated with severe
psoriasis, which Gelfand's other studies have shown can include major cardiovascular events, liver disease and death.
«The type
of inflammation seen in
psoriasis is known to promote insulin resistance, and
psoriasis and diabetes share similar genetic mutations suggesting a biological basis for the connection between the two conditions we found in our study,» said the study's senior author Joel M. Gelfand, MD MSCE, a professor
of Dermatology and Epidemiology at Penn. «We know
psoriasis is linked to higher rates
of diabetes, but this is the first study to specifically examine how the severity
of the disease affects a patient's
risk.»
Using a United Kingdom database, they surveyed general practitioners about BSA affected by
psoriasis and looked at data on 8,124 adults with
psoriasis and 76,599 adults without
psoriasis over the course
of four years, and they adjusted the samples to account for any differences in age, sex, and body mass index and other diabetes
risk factors.
In the meantime, Dr. Ho says
psoriasis patients should be aware
of their depression
risk and consult a doctor immediately if they experience any depression symptoms.
Researchers from the Perelman School
of Medicine at the University
of Pennsylvania found people with
psoriasis that covers 10 percent
of their body or more are 64 percent more likely to develop diabetes than those without
psoriasis, independent
of traditional
risk factors such as body weight.
«
Psoriasis severity linked to increased risk of type 2 diabetes: Measuring body surface area in psoriasis can identify highest risk cases, researchers sa
Psoriasis severity linked to increased
risk of type 2 diabetes: Measuring body surface area in
psoriasis can identify highest risk cases, researchers sa
psoriasis can identify highest
risk cases, researchers say.»
«These findings are independent
of traditional
risk factors for diabetes and still show a strong connection between the increasing severity
of psoriasis and the increasing
risk of developing diabetes, which makes a strong argument for a causal relationship between the two,» Gelfand said.
«People with
psoriasis, particularly those with more severe disease, have an increased
risk for a variety
of other health problems, including obesity, diabetes, high blood pressure, high cholesterol, stroke and heart attack,» says board - certified dermatologist Jashin J. Wu, MD, FAAD, director
of dermatology research at the Kaiser Permanente Los Angeles Medical Center.
Based on recent laboratory work demonstrating that major depressive disorder is associated with increased systemic inflammation, the team
of researchers hypothesized that
psoriasis patients who develop depression are at increased
risk of subsequently developing psoriatic arthritis.
A multidisciplinary team
of researchers at the University
of Calgary, Canada, have found that
psoriasis patients who developed depression were at a 37 % greater
risk of subsequently developing psoriatic arthritis, compared with
psoriasis patients who did not develop depression.
An antibody used to treat the skin disease
psoriasis is also effective at reducing aortic inflammation, a key marker
of future
risk of major cardiovascular events.
Researchers conducted a nationwide, population - based long - term observational cohort study using the Swedish Multi-Generation Register to monitor the
risk of nonceliac autoimmune disease, which includes Crohn's disease, type 1 diabetes mellitus, hypothyroidism, hyperthyroidism,
psoriasis, rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus and ulcerative colitis.
The more the surface area
of the body is covered by
psoriasis, the greater the
risk of death for the patient suffering from the condition, according to a new analysis by researchers in the Perelman School
of Medicine at the University
of Pennsylvania.
The study, which published today in the Journal
of Investigative Dermatology, is the first to link
psoriasis severity to an increased
risk of death using an objective measure
of disease severity — called Body Surface Area (BSA)-- rather than treatment patterns, such as whether or not a patient was receiving oral, injectable or phototherapy treatment for the condition.
«It's well established that
psoriasis is associated with an increased
risk for other comorbidities like chronic kidney disease, diabetes, and cardiovascular disease, but we don't yet understand how the severity
of psoriasis impacts future
risk of major health problems,» said the study's senior author Joel M. Gelfand, MD MSCE, a professor
of Dermatology and Epidemiology at Penn..
The data indicated that patients with ICP have an increased
risk of a variety
of immune - mediated diseases, such as thyroid disease (30 % higher than pregnant controls), diabetes (47 %),
psoriasis (27 %), and Crohn's disease (55 %).
Following adjustments for age, gender, date
of entry into the patient database, duration
of psoriasis, BMI, smoking, alcohol consumption and number
of visits to the general practitioner,
psoriasis patients exposed to trauma were shown to have an increased
risk of PsA compared to controls (hazard ratio, 1.32).
The results
of a large population study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) showed an increased
risk of developing Psoriatic Arthritis (PsA) among
psoriasis patients exposed to physical trauma, particularly when the trauma involved bone and / or joints.
The findings could, in future, lead to the identification
of people with
psoriasis who are at
risk of developing psoriatic arthritis.
The researchers, who are part
of a European consortium, say that their work, which took three years to complete and is published in Nature Communications, is a breakthrough because genetic changes have been identified that increase the
risk of PsA but not
psoriasis.
That means people with psoriatic arthritis — most
of whom developed
psoriasis first — are at
risk as well.
I was considered high
risk because I had the skin condition
psoriasis (about 30 %
of psoriasis patients also develop psoriatic arthritis) for almost 10 years, and my knee was often swollen and dislocated — something I had just attributed to normal wear and tear.
The injectable drugs known as biologics can provide much - needed relief from
psoriasis, but the drugs are powerful and carry a small
risk of potentially serious side effects.
Nutritionists and physicians recommend a healthy, balanced diet to control your weight and your
psoriasis, as well as lower your
risk of heart disease, diabetes, and stroke (which are elevated in people with
psoriasis).
Studies have shown that daily smoking is linked to the
risk of developing the scaly skin condition
psoriasis.
Studies have shown that daily smoking is linked to the
risk of developing
psoriasis.
Eating healthy and maintaining a healthy weight is critical, says Neil Korman, MD, PhD, clinical director
of the Murdough Family Center for
Psoriasis in Cleveland Heights, Ohio: «We do know that people who are obese are at increased risk for psoriasis, and that losing weight may help improve your psoriasi
Psoriasis in Cleveland Heights, Ohio: «We do know that people who are obese are at increased
risk for
psoriasis, and that losing weight may help improve your psoriasi
psoriasis, and that losing weight may help improve your
psoriasispsoriasis.»
Along with decreasing inflammation and the diseases it causes, proper omega - 3 levels have been shown to significantly reduce your
risk of developing rheumatoid arthritis,
psoriasis, asthma, inflammatory bowel disorders such as Crohn's disease and ulcerative colitis, lupus erythematosus, multiple sclerosis and migraine headaches!
PMID: 8977698; Cigarette smoking in men may be a
risk factor for increased severity
of psoriasis of the extremities.
I'm always optimistic nevertheless that I can encourage
psoriasis patients to overcome many
of these high -
risk behaviors and move into wellness behavioral patterns if they choose to do so.
Residual
risk of CHD also comes from factors such as smoking, pollution, autoimmune diseases (e.g. lupus,
psoriasis, RA), infections, and nutritional deficiencies which may not make much impact on a basic lipid panel.
The benefits
of antioxidant rich foods is not limited to reducing any oxidative stress, many antioxidant rich foods can also fight the inflammation
of psoriasis, and are very important to protect a
psoriasis patient against heart disease and cancer, diseases that
psoriasis sufferers are at a higher
risk of developing.
For people with
psoriasis, the
risk of heart attack is almost three times greater than for those without the disease.
The
risk of irregular heartbeats and stroke is also higher in those with
psoriasis.
You see, when you have
psoriasis you may have a weakened immune response and have various other dysfunctions such as hormonal or digestive that can make you more prone to other auto - immune illnesses, an increased chance
of infections and also a higher
risk of food allergies or food sensitivities.
People with
psoriasis have a higher
risk of metabolic syndrome.
One study showed that children with
psoriasis were at much greater
risk of being obese, while another showed being overweight at 18 increased the
risk of developing psoriatic arthritis.
on top
of all this, these poor habits may well contribute to other medical problems that people with
psoriasis are already at higher
risk for, like depression, anxiety, allergies as well as other forms
of auto immune disease and even cancer.
Many patients come to us seeking assistance with their
psoriasis because they have not only become disillusioned with a lack
of permanent results, they have become concerned about the
risks and potentially serious side effects
of the drug - based approach and want to finally get to the root cause
of their
psoriasis.
In general, losing weight does help the battle against
psoriasis and also lowers the
risk of heart disease or stroke,
risks that are elevated for those with
psoriasis.
Studies show that eating fish is beneficial for the circulatory system and minimizes the
risk of heart disease, a condition to which
psoriasis patients are prone.
Psoriasis «In certain patients, psoriasis is a risk factor for heart attack comparable to diabetes,» says Joel M. Gelfand, MD, assistant professor of dermatology at the University of Penn
Psoriasis «In certain patients,
psoriasis is a risk factor for heart attack comparable to diabetes,» says Joel M. Gelfand, MD, assistant professor of dermatology at the University of Penn
psoriasis is a
risk factor for heart attack comparable to diabetes,» says Joel M. Gelfand, MD, assistant professor
of dermatology at the University
of Pennsylvania.