Sentences with phrase «risk than futures»

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

More than ever before, businesses must keep an eye on the wider risk and opportunity landscape in order to ensure current and future profits.

I don't know exactly what's going to happen, but simple math based on the current level of interest rates leads me to believe that these risk premiums will be much wider in the future over longer time frames than they've been in the recent past.

Many lenders consider the increased flexibility of a business credit line higher - risk financing than a more traditional term loan because the business is borrowing in the future based upon their creditworthiness today.

One warning to note: Blooom doesn't use your risk profile or future goals, other than your desired retirement date, to create an asset allocation.

Millions of workers could lose their jobs to robots and artificial intelligence in the future, with some more at risk than others.

My students at Peking University, for example, are extremely supportive and think very differently about what I do, and I think I have convinced them that as future policymakers, especially in finance and central banking, rather than join the hype that has always accompanied every growth miracle it is their responsibility to be focus on risks and on all the ways things can go wrong.

The risks associated with future toxic waste from the oil sands are, in some ways, more worrying than the much more widely known global warming ones.

Leading companies and institutions in more than 50 countries rely on our financial resources, expertise and infrastructure to help them grow their businesses, manage their risks and invest for the future.

Rather than stressing vigilance about future inflationary risks, Fed policymakers re-iterated their view that core inflation was likely to rise only gradually, eventually stabilizing around their 2 % target level.

The extreme volatility swamping markets over the past 10 days has more to do with the future risks perceived by professional traders than with actual performance of a growing economy.

In short, investors should expect smaller excess returns for the risk of owning equities in the future than they enjoyed in the past.

We see future returns driven primarily by income in fixed income and earnings growth in equities, rather than by a re-rating spurred by a decline in rates and risk.

Taking on more equity risk when the expected future returns are lower than in the past and downside risks higher makes little sense to me.

If, for example, a given individual security in a market is offering a more attractive risk - adjusted future return than all of the other securities, and if investors know this, then they will try to buy that security, selling the others as necessary to raise funds.

Alternative investing, including use of futures, options and short positions, may involve risks different from or possibly greater than the risks associated with investing directly in securities and other traditional investments.

Mark Carney, governor of the Bank of England, gave a speech on 2 March on the future of money and how the UK central bank can help manage the potential risks, as well as realise the promise of, more than a thousand virtual or cryptocurrencies.

If low risk and a passive income stream sit high on your list to strengthen your financial future, look no further than residential real estate.

He highlighted that more than 60 per cent of Balama's future production was not yet contracted under a binding offtake contract, and a possible risk that graphite could be replaced in battery anodes by silicon.

With these reservations we might well be of the opinion that the Church in Germany, and not only there, is, on the whole, still tempted to defend old conservative positions rather than to surrender them in order to prepare even now for an inevitable future, despite some conciliar courage to start anew and risk an uncertain future.

«If we do not remain related somehow with the fundamental biological orientation to the future brought reproduction, we run the risk that our other choices will become more concerned with gratification and exploitation and comfort than with responsibility.»

Medical abortions have less than 0.5 % risk of serious complications and do not affect a woman's health or future ability to become pregnant or give birth.

Safety must not trump desert: the risk of future harm to society can not justify doing more to the criminal than he deserves.

The banks will also point out comments by the RBA last week that the risk from the current strength in housing is more likely to be future household spending than to their own balance sheets.

That this House: (1) notes with concern the impact on the Dairy Industry of the Coles milk pricing strategy and that: (a) dairy farmers around the country are today seriously questioning their future having suffered through one of the worst decades in memory including droughts, floods, price cuts and rising cost of inputs such as energy and feed; (b) unsustainable retail milk prices will, over time, compel processors to renegotiate contracts with dairy farmers and the prospect that these contracts will be below the cost of production may force many to leave the industry; (c) the fact that supermarkets are now selling milk cheaper than many varieties of bottled water will be the straw that finally breaks the camel's back for many dairy farmers; and (d) the risk of other potential impacts includes: (i) decreased competition as name brands are forced from the shelves; and (ii) the possible loss of fresh milk supplies to some parts of the country as local fresh milk industries become unviable; and (2) calls on the Government to: (a) ask the ACCC to immediately examine the big supermarkets and milk wholesalers after recent price cuts to ensure they do not have too much market power and are not anti-competitive in their behaviour; and (b) support the new Senate inquiry into the ongoing milk price war between the country's major supermarket chains».

The Celtics have taken on the risk of relying on four future Hall of Famers who have each played more than 35,000 career minutes: If that gamble backfires and Shaquille O'Neal, Kevin Garnett, Ray Allen or Paul Pierce happens to break down, then which contender in the East is going to stop the Heat?

All of the books have to take more juice on these futures because of the risk of massive payouts, but some books are going to be taking more juice than others.

What Football Index has done is spread the net and take away a massive proportion of the risk, allowing you to invest money in the futures of individual players, rather than one - time results.

«Rushing athletes back too soon puts their future in sports at higher risk than should be considered tolerable.

Even if circumcision is proven to slightly lower the risk of acquiring an STD in the future, safe sexual practices (abstinence, fidelity and condoms) are more important and has more to do with preventing STDs than circumcision.

On the other side of the debate, the American Academy of Pediatrics states that the benefits for the infant in terms of reduced risk of infection, adult obesity, allergies, and asthma are so great that breastfeeding must be viewed as an «investment in your child's future» rather than a «lifestyle choice.»

But — if you're still concerned about nitrate levels in spinach — you can further minimize the risk by discarding any water in which you cook the leaves and preparing spinach as needed, rather than cooking it and storing it for future use.

Nick Clegg uses New Year's message to warn that a vote for any other party than the Lib Dems will risk the future of the economy.

While the other party leaders grapple with their own futures — Mr Clegg to hold on to his leadership; Mr Miliband to ponder whether he needs to adapt his «no risk» strategy to get into Number Ten; and Mr Cameron to try to deliver progress on EU reform sooner rather than later and to head off calls for an electoral pact with UKIP — Mr Farage has the luxury of planning his next steps while momentum is on his side.

«Weather can not yet be reliably predicted for more than a few days into the future so the board must consider the risk of future conditions being extremely dry as well as the risk that they will be extremely wet.»

After more than six years of debate that started long before his arrival in the executive mansion in January 2011, Gov. Andrew Cuomo announced last year that the state would ban fracking in New York for the foreseeable future due to health risks.

«Innovation starts with people and ideas, and the United States must nurture our future innovators rather than risk losing them altogether,» Holt said in letters sent to lawmakers.

Adolescents who have engaged in past risky online behavior are much more likely than older young adults to repeat the behavior in the future, according to a new study by researchers seeking to understand the psychological mechanisms contributing to young people's online risk taking.

Given that more than half a billion people live within a few meters of modern sea level, he said punctuated sea - level rise poses a particular risk to those communities that are not prepared for future inundation.

Engineers and seismologists in more than half of the world's countries had few such maps or had waited until major quakes struck to calculate the risks of future shaking, Giardini notes.»

A study of over 224,000 patients and more than 314,000 colonoscopies found that adenoma detection rates closely tracked the future risk of colorectal cancer.

Otherwise, the U.S. risks falling further behind in the race to dominate the clean energy technology markets of the future — becoming a customer, rather than a supplier.

Researchers say these results have implications for understanding disease origin rather than for clinical risk prediction and future studies should focus on the mechanisms underlying the relationship between childhood height and later stroke.

One of the studies Tim has referenced basically concludes that the only thing policymakers can do is work on the assumption that biofuels, at this moment in time, are worse than petroleum fuels because of the future risk of land clearing and other GHG emission increases.

«In fact, it might encourage women to take more financial risks than they can tolerate, which could lead to more problems in the future.

An analysis of diagnostic test results from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial — in which patients with stable chest pain were randomized to either anatomic or functional testing as an initial diagnostic strategy — showed that the presence and extent of coronary artery disease detected by CT angiography better predicted the risk for future cardiac events than did measures of exercise tolerance or restricted blood flow to the heart muscle.

The current study directly analyzed associations between the results of all diagnostic tests and the risk of future cardiac events in around 9,100 of the more than 10,000 patients in the PROMISE trial.

Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the University of Birmingham.

Researchers say their analysis found that rather than disrupting the positive point - of - sale advertising in the convenience store, the graphic anti-smoking poster seemed to further heighten the smoking susceptibility of adolescents already considered at - risk for future tobacco use.

«In the future, we hope to explore whether these changes in distance were also associated with obtaining abortion later in pregnancy, which carries an increased risk of complications and is more expensive than early abortion,» said Grossman, who is a professor of obstetrics, gynecology and reproductive sciences at UCSF.