Not exact matches
These
risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and
other programs; the
risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger
than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for
state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and
state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or
other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the
risk that physicians and patients may not see advantages of these products over
other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or
other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and
other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
debt obligations of the U.S. government that are issued at various intervals and with various maturities; revenue from these bonds is used to raise capital and / or refund outstanding debt; since Treasury securities are backed by the full faith and credit of the U.S. government, they are generally considered to be free from credit
risk and thus typically carry lower yields
than other securities; the interest paid by Treasuries is exempt from
state and local tax, but is subject to federal taxes and may be subject to the federal Alternative Minimum Tax (AMT); U.S. Treasury securities include Treasury bills, Treasury notes, Treasury bonds, zero - coupon bonds, Treasury Inflation Protected Securities (TIPS), and Treasury Auctions
This discussion also does not consider any specific facts or circumstances that may be relevant to holders subject to special rules under the U.S. federal income tax laws, including, without limitation, certain former citizens or long - term residents of the United
States, partnerships or
other pass - through entities, real estate investment trusts, regulated investment companies, «controlled foreign corporations,» «passive foreign investment companies,» corporations that accumulate earnings to avoid U.S. federal income tax, banks, financial institutions, investment funds, insurance companies, brokers, dealers or traders in securities, commodities or currencies, tax - exempt organizations, tax - qualified retirement plans, persons subject to the alternative minimum tax, persons that own, or have owned, actually or constructively, more
than 5 % of our common stock and persons holding our common stock as part of a hedging or conversion transaction or straddle, or a constructive sale, or
other risk reduction strategy.
These
risks and uncertainties include food safety and food - borne illness concerns; litigation; unfavorable publicity; federal,
state and local regulation of our business including health care reform, labor and insurance costs; technology failures; failure to execute a business continuity plan following a disaster; health concerns including virus outbreaks; the intensely competitive nature of the restaurant industry; factors impacting our ability to drive sales growth; the impact of indebtedness we incurred in the RARE acquisition; our plans to expand our newer brands like Bahama Breeze and Seasons 52; our ability to successfully integrate Eddie V's restaurant operations; a lack of suitable new restaurant locations; higher -
than - anticipated costs to open, close or remodel restaurants; increased advertising and marketing costs; a failure to develop and recruit effective leaders; the price and availability of key food products and utilities; shortages or interruptions in the delivery of food and
other products; volatility in the market value of derivatives; general macroeconomic factors, including unemployment and interest rates; disruptions in the financial markets;
risk of doing business with franchisees and vendors in foreign markets; failure to protect our service marks or
other intellectual property; a possible impairment in the carrying value of our goodwill or
other intangible assets; a failure of our internal controls over financial reporting or changes in accounting standards; and
other factors and uncertainties discussed from time to time in reports filed by Darden with the Securities and Exchange Commission.
In Connecticut, Illinois, Massachusetts and New Jersey, there are background checks required for people to buy ammunition and those four
states have 89 percent lower
risk than all the
other states.
Not only was that assertion completely at odds with the uncertain
state of the existing science, but it was contradicted by the study itself, in which Dr. McKee and her colleagues acknowledged that several
other factors, besides prior participation in football, may influence CTE
risk and disease severity, including factors
other than cumulative hits to the head, and admitted that it was even «unclear» what roles concussions and repetitive subconcussive hits play in CTE
risk, disease severity, and progression.
«Babies in the United
States have a higher
risk of dying during their first month of life
than do babies born in 40
other countries, according to a new report.
On the
other side of the debate, the American Academy of Pediatrics
states that the benefits for the infant in terms of reduced
risk of infection, adult obesity, allergies, and asthma are so great that breastfeeding must be viewed as an «investment in your child's future» rather
than a «lifestyle choice.»
The scientists find themselves in legal peril even though anything
other than a loosely probabilistic assessment of earthquake
risk is currently impossible, even with
state - of - the - art meditation techniques.
This conflicts with the AAP's recommendation that babies be placed on their backs for sleep to decrease the
risk of sudden infant death syndrome (SIDS), which is responsible for more deaths during the first year of life
than any
other cause in the United
States.
Influenza remains a major health problem in the United
States, resulting each year in an estimated 36,000 deaths and 200,000 hospitalizations.4 Those who have been shown to be at high
risk for the complications of influenza infection are children 6 to 23 months of age; healthy persons 65 years of age or older; adults and children with chronic diseases, including asthma, heart and lung disease, and diabetes; residents of nursing homes and
other long - term care facilities; and pregnant women.4 It is for this reason that the Centers for Disease Control and Prevention (CDC) has recommended that these groups, together with health care workers and others with direct patient - care responsibilities, should be given priority for influenza vaccination this season in the face of the current shortage.1 Other high - priority groups include children and teenagers 6 months to 18 years of age whose underlying medical condition requires the daily use of aspirin and household members and out - of - home caregivers of infants less than 6 months old.1 Hence, in the case of vaccine shortages resulting either from the unanticipated loss of expected supplies or from the emergence of greater - than - expected global influenza activity — such as pandemic influenza, which would prompt a greater demand for vaccination5 — the capability of extending existing vaccine supplies by using alternative routes of vaccination that would require smaller doses could have important public health implicat
other long - term care facilities; and pregnant women.4 It is for this reason that the Centers for Disease Control and Prevention (CDC) has recommended that these groups, together with health care workers and
others with direct patient - care responsibilities, should be given priority for influenza vaccination this season in the face of the current shortage.1
Other high - priority groups include children and teenagers 6 months to 18 years of age whose underlying medical condition requires the daily use of aspirin and household members and out - of - home caregivers of infants less than 6 months old.1 Hence, in the case of vaccine shortages resulting either from the unanticipated loss of expected supplies or from the emergence of greater - than - expected global influenza activity — such as pandemic influenza, which would prompt a greater demand for vaccination5 — the capability of extending existing vaccine supplies by using alternative routes of vaccination that would require smaller doses could have important public health implicat
Other high - priority groups include children and teenagers 6 months to 18 years of age whose underlying medical condition requires the daily use of aspirin and household members and out - of - home caregivers of infants less
than 6 months old.1 Hence, in the case of vaccine shortages resulting either from the unanticipated loss of expected supplies or from the emergence of greater -
than - expected global influenza activity — such as pandemic influenza, which would prompt a greater demand for vaccination5 — the capability of extending existing vaccine supplies by using alternative routes of vaccination that would require smaller doses could have important public health implications.
Still, the report
states, «Bakken crude oil does not pose
risks significantly different
than other crude oils or
other flammable liquids authorized for rail transport.»
Researchers looked at the diets of more
than 200,000 people in both the United
States and China, and found nut consumption was linked with a lower
risk of premature death from heart disease and
other causes.
Babies, on the
other hand, may be at higher
risk for harm because they are more susceptible to the harmful effects of arsenic
than adults, and baby cereal is rice - based,
States said.
It should be kept in mind that although high Dietary Fiber intake is associated with decreased
risk or improvements in several chronic diseases, a report of the National Academy of Sciences
states â $ there is no conclusive evidence that it is dietary fiber rather
than the
other components of vegetables, fruits, and cereal products that reduces the
risk of those diseasesâ $ (NRC, 1989).
The report found that twice as many foster youth performed «below basic» and «far below basic» on
state academic achievement tests
than students statewide, were much more likely to drop out
than any
other at -
risk student group, and only 58 percent of foster youth 12th graders graduated as compared to 84 percent of all 12th graders in California.
Like any
other state, Mississippi experiences its fair share of crime but certain spots pose less of a
risk than others.
However, the mild California climate brings fewer
risks to homes and properties
than more severe climates in
other states.
In essence, we facilitate lending among our members, creating a situation where both parties benefit: Borrowers pay lower interest rate
than they would on their credit cards or similar unsecure loans, while Lenders receive the interest the borrowers pay at higher rates
than other investment opportunities of comparable
risk (
stated interest rates of 6.69 % -19.37 % after service charge) How many loans have you done (and for what amount)?
While global equity funds can be volatile and involve more
risk than Canadian investments — depending on the
state of world affairs, currency fluctuations and
other economic and political factors — they diversify against any type of country or political
risk an investor might encounter.
Likewise, if you have blemishes on your driving record or fall into some
other high -
risk pool, your auto insurance is all but assured to cost more
than the
state average.
Some
states and areas within them are at a higher
risk than others, so earthquake insurance rates and need can vary greatly.
According to the United
States Fire Administration's Children and Fire in the United
States Report (1994 - 1997), the very young (those under age five) have a much greater
risk from fire
than others.
Although some areas are at higher
risk than others, heartworm infection has been found in dogs throughout all of the United
States.
Texas pets have a higher
risk of heartworm infection
than many
other states because of its hot and humid climate.
Heartworms have been found in all 50
states, although certain areas have a higher
risk of heartworm
than others.
Texas pets have a higher
risk of heartworm infection
than many
other states because of its warm climate.
I'm not well up on the
state of the research today,
other than the facts that there is a lot of it, and that there are competing effects in play which researchers are attempting to pin down; but the
risk is clearly well beyond «assumption.»
[Nov. 18, 11:37 p.m. Updated Vaclav Smil, the Canadian resource and
risk analyst, has written a potent critique of Obama's move, noting, among
other things, «If there would be no oil - sand oil produced in Alberta to feed the XL pipeline and then refined in the United
States and the products burned in American vehicles, then the Chinese would generate an additional mass of CO2 equivalent to that prevented burden in less
than two weeks.»]
I'm convinced that the United
States will be better off keeping existing nuclear power stations running, where their management can be demonstrated to be reliable, rather
than initiating a decades - long decommissioning process that would not resolve community concerns about spent fuel and many
other sources of
risk.
The same month, the
state's Air Resources Board (ARB) decided to shift the
risk of invalidated offsets to buyers (rather
than sellers) of compliance forestry offsets, putting it in line with
other offset protocols.
In arguing that the United
States or
other high - emitting nations need not reduce their ghg emissions to their fair share of safe global emissions based on cost, how have you considered, if at all, that all nations have agreed in international climate negotiations to take steps to limit warming to 2 degree C because warming greater
than this amount will not only create harsh impacts for tens of millions of people but runs the
risk of creating rapid non-linear warming that will outstrip the ability of people and nations to adapt?
To date all operating nuclear power plants were developed by
state - owned or regulated utility monopolies [2] where many of the
risks associated with construction costs, operating performance, fuel price, and
other factors were borne by consumers rather
than suppliers.
Water Shortages Increase for US Counties by 2050 Due to Climate Change New research in the Journal of Environmental Science & Technology shows «more
than 1 in 3 counties in the United
States could have a «high» or «extreme»
risk of water shortages due to climate change by the middle of the 21st century... 7 in 10 of the more
than 3,100 US counties could face «some»
risk of shortages of fresh water for drinking, farming, and
other uses.»
As
stated in Briggs and Rees Civil Jurisdiction and Judgments (2005) 4th edition at paras 2.02 to 2.07 & 2.105: (i) The fundamental rule was that if a case fell within the Brussels Regulation, the Regulation alone allocated jurisdiction over the defendant; (ii) There were three overriding principles of interpretation: (i) the wording of the regulation should so far as possible be given a meaning which was common and uniform across the various member
states; (ii) provisions which allowed a defendant to be sued against his will in a member
state other than his domicile were to be construed narrowly; (iii) the
risk of inconsistent decisions should be kept to a minimum.
The construction industry contains many inherent
risks, but New York appears to have greater incidents of worker injuries and fatalities
than other states in the country.
But Florida, along with most
other States, has reasonably concluded that solicitation by the candidate personally creates a categorically different and more severe
risk of undermining public confidence
than does solicitation by a campaign committee.
More
Than Forty People in Indiana Sickened in Fungal Meningitis Outbreak;
State Seeks to Revoke License of Pharmacy Where Outbreak Allegedly Originated, Indiana Injury Lawyer Blog, October 31, 2012 Federal Statute Preempts
State Products Liability Lawsuit Over Asbestos Exposure, According to Supreme Court: Kurns v. Railroad Friction Products Corp., Indiana Injury Lawyer Blog, October 18, 2012 Spinal Fractures, Traumatic Brain Injury, and
Other Risks Posed by Trampolines, According to Pediatricians, Indiana Injury Lawyer Blog, October 12, 2012 Photo credit: «Yummy popcorn» by shannahsin on stock.xchng.
The
risk of theft is higher in a large city like Phoenix
than it is in
other parts of the
state.
While New Jersey motorists really have to pay higher auto insurance rates
than those in most
other states, they do enjoy very low auto theft rates and average
risk of being in a car accident.
Florida has designated certain coastal areas throughout the
state as high -
risk areas, or those more prone to wind and hurricane losses
than others.
Likewise, if you have blemishes on your driving record or fall into some
other high -
risk pool, your auto insurance is all but assured to cost more
than the
state average.
Theft is a big problem in North Carolina as well as in every
other state in the country, and people who are renting are going to be at a larger
risk of theft
than others.
While New Jersey drivers do have to pay higher auto insurance rates
than those in most
other states, they do enjoy very low auto theft rates and moderate
risk of being in an automobile accident.
Some
states and areas within them are at a higher
risk than others, so earthquake insurance rates and need can vary greatly.
Because the
risk of a major quake in New York is lower
than in
other states, you can usually get the extra insurance you need at a very reasonable rate.
The truth, however, is that
state minimums are rarely sufficient to cover much more
than a minor auto accident, and don't provide any protection against
other potential
risks.
Perhaps more so
than in
other states, North Dakota is at an increased
risk for a natural disaster to occur that could result in the loss of your possessions.
However, the mild California climate brings fewer
risks to homes and properties
than more severe climates in
other states.
Hail damage can occur almost everywhere in the US, but as you can see, the
risk is slightly higher in Minnesota
than in
other states.