Sentences with phrase «risperidone bound»

Wang said, «Now that we've solved the structure of risperidone bound to DRD2, we are getting an idea how these side effects could be avoided.»

Not exact matches

Now, scientists at the UNC School of Medicine and UC San Francisco (UCSF) have solved the first high - resolution crystal structure of the dopamine 2 receptor (DRD2) bound to the antipsychotic drug risperidone, yielding a long - awaited tool for drug developers, psychiatrists, and neuroscientists.

To transcend the technical challenges, Roth and UNC colleagues, including postdoctoral fellows Sheng Wang, PhD, and Daniel Wacker, PhD, conducted a series of painstaking studies over several years — outlined in the Nature paper — to coax DRD2 to crystalize while bound tightly to risperidone.

Solving the high - resolution crystal structure of DRD2 bound to the commonly prescribed antipsychotic drug risperidone is the first step towards the creation of safer and more effective medications for schizophrenia and related disorders.»

Further computational modeling performed by UCSF researchers Brian Shoichet, PhD, and Anat Levit, PhD, revealed that risperidone's binding mode was unpredictable — there was a previously unseen pocket on the receptor which Roth and colleagues think could be targeted to create more selective medications.