Sentences with phrase «robust model of human disease»
Thomas W Geisber, an expert on Ebola and siRNAs at The University of Texas Medical Branch, said the research was «highly significant because it shows protection against Ebola in a robust model of human disease: non-human primates.»
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«If human organs on chips can be shown to be robust and consistently recapitulate complex human organ physiology and disease phenotypes in unrelated laboratories around the world, as suggested by early proof - of - concept studies, then we will see them progressively replace one animal model at a time.
Molecular mechanism underlying diseases (conformational diseases, cystic kidney disorders, neuromuscular diseases, inflammation, iron - related diseases, disorders of human reproduction, osteoporosis and bone diseases) are being investigated by many groups with robust animal and cellular models and patients» biological samples.
Human primary hepatocytes and immortalized cell lines (e.g., HepaRG) are used to study these disorders, but due to these cells» high variability, low availability, short assay window, or lack of physiological relevance, researchers studying metabolic diseases are searching for more robust and reliable models.
These studies allow the construction of robust in vitro human disease models, and also provide a path towards precision medicine and therapeutic genome editing.
There are currently no disease - modifying treatments that have been shown to slow the progression or delay the onset of HD in humans; however, several compounds have demonstrated promise in animal models of HD.1 Robust and sensitive markers of disease progression are required to assess their efficacy in humans.