Syntaxin 3 and SNAP - 25 pairing, regulated by omega - 3 docosahexaenoic acid, controls the delivery of rhodopsin for the biogenesis of cilia - derived sensory organelles,
the rod outer segments.
Cell nuclei,
rod outer segments, and donor - derived retina are blue (DAPI), red (XAP2), and green (Venus YFP), respectively.
The rod outer segment is made up of stacked discs each containing many types of proteins, in particular rhodopsin, a light - sensitive pigment.
In wild - type, retinal ganglion cell layer (GCL), inner nuclear layer (INL), inner plexiform layer (IPL), and nuclear layers of rod and cone photoreceptors are distinct, and
rod outer segment (OS) is observed at the outer-most layer of the retina.
Previous studies have shown the requirement of CNGB1 for normal targeting of CNGA1 to
the rod outer segment [16] and indeed the authors were able to demonstrate a lack of detectable CNGA1 protein in the rod outer segments of the affected Papillons homozygous for the mutation [15].
Not exact matches
Reduction of all - trans retinal to all - trans retinol in the
outer segments of frog and mouse
rod photoreceptors.
Interphotoreceptor retinoid - binding protein is the physiologically relevant carrier that removes retinol from
rod photoreceptor
outer segments.
Rapid formation of all - trans retinol after bleaching in frog and mouse
rod photoreceptor
outer segments.
In RCD3 affected dogs normal
rod - mediated ERG responses fail to develop, photoreceptor
outer segments do not reach maturity and
rod cells are lost by apoptosis [5].