Sentences with phrase «rodent model»

Using rodent models of opiate addiction, Dr. Laviolette's research has shown that opiates affect pathways of associative memory formation in multiple ways, both at the level of anatomy (connections between neurons) and at the molecular levels (how molecules inside the brain affect these connections).

The results were obtained from mice and human stem cells in cultivated brain tissue, and from a series of rodent models for human neurodegenerative diseases and acute brain injuries.

Using neurons extracted from rodent models of Huntington's, the team employed the OPL method, which tracked the speed and efficiency with which different types of neurons were able to break down and dissolve the mutant huntingtin.

For such study, we have used the McGill - R - Thy1 - APP transgenic rat, which is unique compared to other rodent models in that the AD - like phenotype has been achieved with a single genomic insertion of a mutated human APP transgene; minimizing off - target genetic corruption and therefore being closer to the human disease [32].

Since the presence of phytoestrogen containing sources (i.e. soy protein and isolated isoflavones) has been found to influence atherosclerosis and lipoprotein metabolism in various rodent models (7 - 13), the use of purified Western - type diets provides a clean «reagent» for inducing this disease.

Animal rodent models are useful tools for studying obesity as they will readily gain weight when fed high - fat diets.

More importantly, in vivo inhibition of intestinal and lung inflammation rodent models suggests effectiveness to resolve inflammation with low toxicity to the animals.

Functional studies in rodent models suggest that OPHN1 linked ID is a consequence of abnormal synaptic transmission and shares common pathophysiological mechanisms with other cognitive disorders.

High - magnesium diets have preventive (though not curative) activity in certain rodent models of diabetes; conversely, magnesium depletion provokes insulin resistance.

«We commonly think of drug addiction as making the drug more important than anything else in the user's life, but we haven't had good rodent models of that,» said Taffe.

Furthermore, testing rodent models of genetic disorders affecting memory, like Alzheimer's, can be used to characterize molecules that could either be risk factors or potential therapeutics for the disease.

Join us to discuss how rodent model diets shape experimental outcomes, with a particular focus on microbiome and gut health.

The study used a proven rodent model of HO that mimics the injuries seen in combat casualties.

Unlike rodent models, which are developed from inbred strains of mice kept in controlled environments, companion animals, like humans, are genetically diverse and are exposed to many of the same environmental influences as their owners are.

Dr Sottile added: «This new system gave us an advantage over previous rodent models as we could study more accurately how specifically human cells would be affected by a decrease in temperature.

In the new study, Dr. Greenamyre and his team — led by coauthors Roberto Di Maio, Ph.D., and Paul Barrett, Ph.D., both of PIND — used a well - established rodent model of PD to show exactly how alpha - synuclein disrupts mitochondrial function.

The paper, by S.S. Karuppagounder at Burke Medical Research Institute in White Plains, N.Y., and colleagues was titled, «Therapeutic targeting of oxygen - sensing prolyl hydroxylases abrogates ATF4 - dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.»

This work illustrates how the study of inbred canine populations can provide new insights into the genetic underpinnings of complex disease, bridging the gap between small rodent models and humans.

Emory's Donald (Tig) Rainnie and his research team use freely moving rodent models to examine the effects of DBS on neural circuits thought to be disrupted in depression.

Data from leptin - deficient rodent models have revealed regionally specific effects on the skeleton, with reports of cortical bone atrophy in weight - bearing long bones like the femur and tibia (11 — 16).

Previous work in rodent models indicates that WBV attenuates muscle atrophy with disuse and aging and in experimental models of menopause (23, 51 — 53).

During my research activity, I have described the circuital substrates modulated by centrally - active agents in multiple areas of experimental neuroscience (e.g. schizophrenia, depression, drug addiction etc.) and identified functional and structural alterations in different rodent models of brain pathology.

Today, there are more DIO rodent models made using our diets than any other diets in the world.

We have produced all the cells and tested them in 500 rodent models looking for tumor growth.

Lard has been and continues to be used frequently as a fat source in rodent diets, especially for those interested in promoting obesity in susceptible rodent models.

Title: Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models Author: L. Lyon et al..

Importantly, unlike human or other diet - induced rodent models of NAFLD, rodents fed MCD diets lose weight (due to a vastly lower caloric intake) and do not become insulin resistant (9, 19).

Several studies have reported the existence of intracellular Aβ within cultured neurons [36, 56 — 59] as well as in post-mortem brains from AD [14, 16, 60], DS subjects [17 — 19] and in transgenic rodent models [10, 12, 13, 61, 62].

Extending these results into rodent models of H. pylori - induced inflammation and carcinogenesis (Mongolian gerbils and mice), we have shown that inactivation of such genes attenuates the development gastric injury and cancer.

Autoimune Disease: type 1 diabetes — Remodeling rodent models to mimic type 1 diabetes.

Because of the rarity of bRG cells rodent models, the mechanisms controlling proliferation and self - renewal of these neural stem cells remain largely unexplored.

Thursday 19 April 2018 8:30 — 9:15 Marie - Christine Birling (The Institut Clinique de la Souris, Strasbourg, France) CRISPR for the generation of innovative rodent models (the lecture takes place in yellow and blue seminar room of BIOCEV)

A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy.

In dramatic contrast to the poor repair outcomes for humans and rodent models such as mice, salamanders are able to completely regenerate heart tissue, whole limbs and many other tissues following injury, at any life stage.

To accelerate early development of vaccines, in vivo rodent models are being evaluated for their ability to predict human protective immune responses.

My lab is is a research unit of the Department of Surgery located on the veterinary hospital campus, primarily focused on translational research using complex nonhuman primate (NHP) disease models and screening rodent models.

Generally, Lascelles notes, companion animal disease models better reflect the complex genetic, environmental and physiological influences in human diseases, as opposed to the traditional rodent models.

Although rodent models support this possibility, results from human studies have been decidedly mixed.

In contrast, rodent models demonstrating functional enhancement reveal that brief separation of neonates from their mother and home environment leads to a range of advantages relative to controls (4 — 7).

It only infects primates so researchers can't use rodent models to study the disease.

In other places the authors extrapolate inappropriately from data on rodent models or data relating to different health outcomes (e.g. cancer).

Findings from rodent models of obesity have shown that WBV attenuates dyslipidemia (45, 46).

Rodent models for atherosclerosis.

Animal rodent models are therefore useful tools for studying obesity as they will readily gain weight when fed high - fat diets (1, 2).

In order to understand more about the impact of refined carbohydrates on health and therapies to reduce these metabolic syndrome (MS) phenotypes, certain rodent models have been useful.