Influence of Intestinal Microbiota Transplantation and NleH Expression on
Citrobacter rodentium Colonization of Mice
But when the researchers added bacteria from 16 - day - old normal mice, the amount of
C. rodentium in the guts of surviving mice went down.
They observed that the more dangerous E. coli - like bacteria called Citrobacter
rodentium flourished more in the guts of mice fed a fiber - free diet.
Influence of Intestinal Microbiota Transplantation and NleH Expression on Citrobacter
rodentium Colonization of Mice — Gaochan Wang — Pathogens
They observed that the more dangerous E. coli - like bacteria called Citrobacter
rodentium flourished more in the guts of mice fed a fiber - free diet.
Both
C. rodentium and Salmonella flourished in these environments.
They infected the mice with Citrobacter
rodentium, a species of bacteria that is the rodent equivalent of E. coli, which infects humans.
In mice, the pathogen Citrobacter
rodentium can disrupt this layer and cause inflammation and diarrhea.
The researchers deleted the HIC1 gene in certain innate lymphoid cells in the mouse intestine and found that this increased the susceptibility of the mice to infection with the bacterium Citrobacter
rodentium.
They exposed groups of these mice to C.
rodentium — and found that only the mice given Clostridia were able to resist the infections.
They tried it again with Citrobacter
rodentium — a strain of bacteria similar to the E. coli strains that make humans sick.
Several studies are ongoing using the colitis transfer model, as well as an experimental mouse model in which colitis is induced by the pathogenic enterobacteria Citrobacter
rodentium.
Mice lacking ILCs are more susceptible than control mice to such pathogenic bacteria as Citrobacter
rodentium or K. pneumoniae [40, 55].