Sentences with phrase «role as a tumor»

And in view of PTEN's critical role as a tumor suppressor, it's also important that the process we uncovered is a controlled one, not random as was previously believed.»

Not exact matches

«We also confirmed a role in PDAC tumor maintenance as inhibition of PRMT1 in patient - derived mouse models significantly inhibited tumor growth and extended survival,» said Giuliani.

Correspondingly, a large number of genes with no direct role in tumor progression also are deleted as a result of their proximity to tumor suppressor genes.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

These findings also have implications for treatment of cancer and other disorders, such as obesity, in which M2 macrophage cells play a regulatory role in tumor growth and fat deposition.

Although BRCA1's role in tumor initiation is well known, the fact that it also seems to be involved in tumor progression comes as a surprise, says Eliot Rosen, a molecular biologist at Georgetown University in Washington, D.C.

Viruses may play crucial roles in pacifying the mother's immune system into accepting the placenta, just as they do in helping some tumors survive.

«Also, because Notch is known to be a tumor suppressor, the essential role of Rumi in Notch activation suggests that Rumi could be a tumor - suppressor as well.

For most available T cell immunotherapies, T cells (which play a central role in defending the body against illness) are engineered to recognize and eliminate tumors, but their activity is not specifically controlled, leading to toxicity and unwanted side effects in patients as a result of inflammation or in some cases suboptimal response to treatment.

Now, results of a new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful role for the protein in normal breast cells, acting as a tumor suppressor that halts abnormal cell growth.

In a series of in vitro experiments, the researchers demonstrated that C / EBPα indeed works as a tumor suppressant by restraining the expression of another molecule known to play a role in triggering and maintaining tumor growth.

Modeling APC, a gene whose role in lung cancer is not as well understood, revealed that APC loss also drives tumor progression.

The key experiments included for replication were selected because they examine the induction of POSTN expression in the pulmonary stromal fibroblasts and test the role of POSTN in primary tumor formation and metastatic efficiency, which are relevant as the role of POSTN as a possible prognostic marker and target for anticancer therapies is explored (Xu et al., 2012; Nuzzo et al., 2014).

A marker in bile known as vascular endothelial growth factor (VEGF) plays an important role in the growth of cancerous tumors according to new research presented at the 78th Annual Scientific Meeting of the American College of Gastroenterology.

As important mediators of cell adhesive behavior, integrins play a critical role in tumor progression and metastasis.

Finally, Dr. Goldenring's laboratory is also investigating the role of Rab25 as a tumor suppressor in the colon using the Rab25 - / -; Smad3 + / - mouse model, which develops spontaneous invasive distal colon cancers.

June 2, 2016 Novel immunotherapy approach shows promise in blood cancers A protein known as STING plays a crucial role in the immune system's ability to «sense» cancer by recognizing and responding to DNA from tumor cells.

Our PDX models and other next - generation cancer modeling platforms allow you to address critical questions in oncology research, such as unexplained drug resistance, drug efficacy, genomic heterogeneity in solid tumor, and the role of the immune system in drug response.

Yongwon Choi, with Ralph Steinman and others, identifies a new tumor necrosis factor family member TRANCE (later called RANKL), [i] and subsequently demonstrates its role in the immune and bone system, and also in bone - residing cancers such as multiple myelomas.

As an assistant professor at the Boston University Medical School, she became interested in the control of cellular senescence and its role in tumor suppression and aging.

The SDF - 1 / CXCR4 axis is gaining significant attention mainly due to its important roles in pathological processes, such as HIV entry, tumor metastasis, cell trafficking in autoimmune diseases and inflammatory conditions [10].

Since starting her new role as an investigator in the In Vivo Pharmacology group at Novartis Oncology, Bhang has been working on using the ClonTracer library to monitor clonal dynamics following drug treatment in cell line and primary tumor xenograft models.

I will investigate whether the enteric nervous system, an neglected member of the tumor - microenvironment, plays a role in the development of colorectal cancer and can be used as a potential therapeutic target.

The role of genetic alterations in the microenvironment of sporadic and heritable breast carcinomas and other solid tumors are being examined as they relate to clinical outcome.

Accordingly, it is worth exploring the role of ActD as a p53 activator to reduce the growth of tumors.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

An inverse correlation has been found between DAXX and DAPK1 / 3 mRNA expression in a diverse collection of human tumor cell lines and tumor specimens [Submitted], suggesting that DAXX's role as a transcriptional repressor of DAPK1 / 3 [2] is broadly relevant to tumor biology and is not restricted to PCa.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

Researchers led by St. Jude Children's Research Hospital scientists have worked out how a crucial cancer - related protein, a «histone writer» called Ezh2, plays a role in suppressing as well as driving the most aggressive form of the brain tumor medulloblastoma.

More specifically, he researches the use of anti-CEA antibodies for tumor imaging and therapy, as well as the role of CEACAM1 in T - cell activation and mammary epithelial cell polarization.

One of my other important roles at the Cancer Institute is as part of the pituitary surgery program, as I have extensive training in minimally invasive, endoscopic approaches to tumors of the pituitary region.

In essence, Knudson, far ahead of his time (and ahead of his own hard data) hypothesized that some genes» normal role in life is to behave as anticancer or tumor - suppressor genes that keep cell division under healthy control.

A role of HUWE1 has been very controversial in the context of cancer biology — some studies report HUWE1 as a tumor suppressor, while other studies show HUWE1 as having the potential to cause cancer.

: The aforementioned catechins, known as a potent antioxidants, contained in the matcha leaf may play a major role in preventing and reducing the risk of cancer as they activate detoxification enzymes in the body and help improve immune system function, which can repair damaged cells and prohibit growth of tumors.

Given the well - established role of steroid hormones in breast cancer etiology for postmenopausal women, these findings may have important health implications» Tumor growth from these hormone imbalances is also evident «A dramatic increase in estrogen - dependent malignant diseases, such as ovarian, corpus uteri, breast, testicular and prostate cancers has been recognized.

While genetics and environmental factors can play a role in the disease's development, other variables such as toxins, radiation, and tumor viruses, as well as hormones can also be responsible for causing several types of cancer.

It is advised to monitor these pets closely throughout their lives for mammary (breast tissue) tumors as it is unknown what role the extra hormone exposure may have in tumor development.