Sentences with phrase «role in cancer cell»

«By identifying CD151 and its underlying role in cancer cell survival, we hope to develop a therapy to target it.

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It also boosts the body's immune response against infections and cancer cells and plays an important role in thyroid function and fertility.

Through CBR ®, we also help families to preserve newborn stem cells, which are used today in transplant medicine for certain cancers and blood, immune and metabolic disorders, and have the potential to play a valuable role in the ongoing development of regenerative medicine.

It may now be possible to investigate whether the failure of mRNAs to move to the proper part of the cell — or a lack of balance between mRNAs in the high - and low - production areas of the cell — may play a role in such diseases as colitis and Crohn's disease, and possibly also in bowel cancer.

If this gene plays a role in energy homeostasis and energy balance in the context of obesity, Wang reasoned, perhaps it could play a role in the energy requirements of liver cancer cells.

Moffitt researchers found that YAP1 plays an important role in cancer stem cell self - renewal.

«Cdk2 cell cycle kinase seems to play a role in the ability of cancer cells to be more aggressive and resistant to standard chemotherapy,» Dr. Opyrchal said.

«Important molecule in ovarian cancer: Molecule plays pivotal role in making ovarian cancer cells so lethal.»

However, as has been discovered by a team of Frankfurt - based researchers, these cells do have a weakness: In the current edition of the high impact journal «Cancer Research,» they report that the enzyme 5 - lipoxygenase (5 - LO) plays a significant role in the survival of leukaemic AML stem cellIn the current edition of the high impact journal «Cancer Research,» they report that the enzyme 5 - lipoxygenase (5 - LO) plays a significant role in the survival of leukaemic AML stem cellin the survival of leukaemic AML stem cells.

«As scientists, we have focused a good deal of attention on understanding the role of stem cells in the development of cancers, but there hasn't been a focus on mature cells,» said senior investigator Jason C. Mills, MD, PhD, a professor of medicine in the Division of Gastroenterology.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

But a new study suggests that mature cells also play a key role in initiating cancer — a finding that could upend the way scientists think about the origins of the disease.

The genetic circuit produces the machinery necessary for the production of a compound that inhibits a protein which has a significant and critical role in the growth and survival of cancer cells.

These findings also have implications for treatment of cancer and other disorders, such as obesity, in which M2 macrophage cells play a regulatory role in tumor growth and fat deposition.

At first it was thought that only functioned as cellular debris warehouses but in recent years has been that could have an important role as a messenger between cells of the body and now many groups focus their research on the role that could be played exosomes in various diseases, including cancer.

Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environmenIn an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environmenin cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environmenin cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environmenin a hypoxic environment.

These relatively normal tissue cells communicate with the cancer cells and play a major role in cancer progression, and could offer a new target for treatment.

Using the same computer - based approach, the team has now been able to target the c - FLIP (cellular FLICE [FADD - like IL - 1β - converting enzyme]- inhibitory) protein, known to play a key role in cancer stem cell maintenance and survival, described in previously published work by the Institute.

Stagljar and his colleagues also applied the new technology, which they dubbed MaMTH (for Mammalian - Membrane Two - Hybrid assay), to identify a protein that plays a role in the most common form of lung cancer called non-small cell lung cancer.

A rare - stem like tumor cell, which plays a critical role in the spread of breast cancer, is identified with immunostaining for the?

About ten years ago, research results showed that things are not quite as simple as that: «Under most conditions, H2O2 is not an undesired side product but rather an essential chemical messenger that plays an important role in regulating the way in which body cells respond to signals from outside such as hormones and growth factors,» says Dr. Tobias Dick of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ).

The new research, which studied the immortalization process using genome - engineered cells in culture and also tracked skin cells as they progressed from a mole into a malignant melanoma, suggests that telomerase plays a more complex role in cancer.

Rare stem - like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researcancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researCancer Center researchers.

As cell phones and smart phones take over more communication, information and entertainment functions, concerns about their possible role in causing brain cancer are buzzing on the airwaves.

«Two - step process leads to cell immortalization and cancer: Clearer view of the role telomere length and telomerase play in cell immortalization.»

Olaparib is good at killing cancer cells that have errors in genes that have a role in repairing damaged DNA such as BRCA1 or BRCA2.

Working with human breast cancer cells and mouse models of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs.

Resar says the team plans to continue investigating the function of HMGA1 and SOX9 in intestinal and other cancers as well as their role in stem cells.

Moffitt Cancer Center researchers have found that a protein called TBK1 plays an important role in the process of cell division, especially at a stage called mitosis.

Many genes that are involved in the growth and development of embryos or adult stem cells also play roles in cancer, Resar adds.

Researchers have identified a group of immune system genes that may play a role in how long people can live after developing a common type of brain cancer called glioblastoma multiforme, a tumor of the glial cells in the brain.

Research from Rutgers Cancer Institute of New Jersey shows that the RUNX2 protein, which regulates the transcription of genetic messages responsible for the different functions of cells, may play a role in melanoma cell growth and spread and could serve as a therapeutic target for the disease.

Dr. Ella Evron and Dr. Ayelet Avraham of the TAU - affiliated Assaf Harofeh Medical Center, together with Prof. Saraswati Sukumar of Johns Hopkins, have found that «gene regulation,» the process that shuts off certain parts of a cell's DNA code or blueprint in healthy breast tissue cells, may also play a critical role in the development of breast cancer.

«However, we now know that lymphatic vessels enable metastasis, and other studies also show that they play an important role in whether or not immune cells recognize and attack cancer cells.»

A new study that confirms the role of a protein called PAK4 in the movement and growth of pancreatic cancer cells could help researchers find new ways to tackle the disease.

Mice lack colonic BMI - 1 stem cells that play a critical role in how colon cancer forms — or carcinogenesis — and how material passes through the cell lining of the intestinal wall — or gut permeability.

More importantly, the fibronectin part of the complex is expressed during a cell's transition to cancer and plays a role in cell growth, migration and differentiation.

The scientists also studied the role this pathway might play in cancer cells.

A team headed by Gedas Greicius and Professor David Virshup, Director of the Programme in Cancer & Stem Cell Biology in Duke - NUS Medical School, studied the source and functional role of Wnts and RSPO3.

The work, funded by national charity Pancreatic Cancer Research Fund, uncovers new evidence that PAK4 plays a key role in enabling cancer cells to grow and to spread from the pancreas into other areas of the body, a process called metasCancer Research Fund, uncovers new evidence that PAK4 plays a key role in enabling cancer cells to grow and to spread from the pancreas into other areas of the body, a process called metascancer cells to grow and to spread from the pancreas into other areas of the body, a process called metastasis.

Over 2,000 miRNAs are present in human cells, playing various crucial roles in development, cell differentiation, cell division, cell death, and cancer development.

In addition, he investigates the role of glucose metabolism in cell proliferation and survival of cancer cells, and how it could be exploited for cancer therapIn addition, he investigates the role of glucose metabolism in cell proliferation and survival of cancer cells, and how it could be exploited for cancer therapin cell proliferation and survival of cancer cells, and how it could be exploited for cancer therapy.

To determine whether L1CAM has a role in cancer, the researchers looked for its protein in normal skin cells, cultured noncancerous cells, and aggressive melanomas from 11 patients.

Near - death experiences may play a role in embryo development and help cancer cells that survive chemotherapy spread throughout the body, Denise Montell, a cell biologist at the University of California, Santa Barbara, reported December 6 at the annual meeting of the American...

«We challenged a current dogma in the field that emphasized PLK1's role in mitosis (cell division) as a primary mechanism for cancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medcancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of MedCancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of MedCancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medicine.

He says that the extracts from their fibroblasts do contain the sticky substance, but that in spalacids it does not seem to play a key role in the animals» natural resistance to cancer or activity against cancer cells in the lab.

This particular liver cancer arises from a mutation that produces an abnormal form of the enzyme that is the topic of this current work, protein kinase A, and alters the enzyme's role in cell signaling.

«Recent successes in cancer immunotherapy — in the form of immune checkpoint inhibitors and adoptive T cell transfer — demonstrate how activated immune cells can eradicate tumors, but until now we didn't fully appreciate immunosurveillance or the role of adaptive immunity in tumor formation,» said senior author Michael Karin, PhD, Distinguished Professor of Pharmacology and Pathology at UC San Diego School of Medicine.

Illinois researchers found that the shape of a tumor may play a role in how cancer cells become primed to spread.

«Master regulator» role for little - known protein in cancer cells discovered.»