Sentences with phrase «role in cancer progression»

The answers they have discovered so far reveal critical information about gene regulation; specifically, that cells are used to record the positional identity in human tissues, and that the «perturbation,» the disturbance, of such programs plays a major role in cancer progression, especially in metastasis, whereby cancer cells spread to other parts of the body.

Early studies provided the initial correlative suggestion that loss of alpha2 beta1 integrin expression might play an important role in cancer progression.

«It has become very clear that the opening up or tightening of chromatin, to expose or hide genes in our chromosomes, plays a role in cancer progression,» dos Santos says.

Scientists have found that miRNAs regulate early development, for example, and may play a role in cancer progression.

The study not only offers a novel method to study K - Ras, which is only 1/100, 000 th of an inch across, but also shows how the protein's geometry could explain its role in cancer progression.

These relatively normal tissue cells communicate with the cancer cells and play a major role in cancer progression, and could offer a new target for treatment.

Given that S1P cause cell survival, proliferation, migration and angiogenesis, we hypothesized that S1P play critical roles in cancer progression.

Not exact matches

PDAC genetic analyses show that KRAS mutations are encountered in a majority of patients and play a significant role in cancer initiation, progression and metastasis.

Previous studies have implicated the roles of both EDD1 and TIP60 in cancer progression, however their roles in viral - mediated cancers have not been well - explored.

It is believed that epigenetics play a huge role in the development and progression of cancer.

He says it's also important to understand the protein's biological role in cellular signaling and normal animal development as well as to consolidate its role in human cancer development, progression and drug - resistance.

Investigators found that NPTX2 was expressed in all stages of kidney cancer, especially metastasis, which suggests it plays an important role in tumor development and progression.

She is investigating the role of glycosylated molecules in tumor progression and metastasis, tissue - and species - specific expression of lectin receptors that play a role in regulating host innate immune responses and inflammation, and the immunological mechanisms underlying chronic inflammation and cancer development.

«This suggested to us that we should study annexin's role in pancreatic cancer progression.»

Next steps for the team include identifying microbiota metabolites whose levels are either significantly elevated or depleted during diseases such as IBD or cancer, to find disease - specific markers and explore possible roles for these metabolites in disease progression.

Research findings indicate that abnormal CaSR function and / or abundance play a significant role in the development or progression of several non-communicable diseases (or NCDs) such as Alzheimer's disease, cardiovascular diseases, diabetes, cancer, and degenerative muscle loss.

In The Journal of Clinical Investigation researchers from VIB, KU Leuven (Belgium) together with colleagues from INSERM (France) now report the important role for FES in the initiation and progression of melanoma, a malignant type of skin cancer, that is notoriously quick to metastasize and that responds poorly to existing cancer treatmentIn The Journal of Clinical Investigation researchers from VIB, KU Leuven (Belgium) together with colleagues from INSERM (France) now report the important role for FES in the initiation and progression of melanoma, a malignant type of skin cancer, that is notoriously quick to metastasize and that responds poorly to existing cancer treatmentin the initiation and progression of melanoma, a malignant type of skin cancer, that is notoriously quick to metastasize and that responds poorly to existing cancer treatments.

Modeling APC, a gene whose role in lung cancer is not as well understood, revealed that APC loss also drives tumor progression.

Cancer stem - like cells (CSC) are considered to play a role in metastatic progression of breast cancer; however, the exact pathologic role of CSCs is yet to be eluciCancer stem - like cells (CSC) are considered to play a role in metastatic progression of breast cancer; however, the exact pathologic role of CSCs is yet to be elucicancer; however, the exact pathologic role of CSCs is yet to be elucidated.

The first experiment is to measure metastatic lung cancer in MMTV - PyMT transgenic mice crossed with the POSTN Knock out mice, and controls, with focus on the role of periostin in metastatic progression.

Furthermore, additional studies are needed to elucidate the causal role of vaginal microbiota in HPV status and progression to cervical cancer.

Therefore, we have explored the role of the alpha2 beta1 integrin in cancer initiation and progression using a clinically - relevant, spontaneous mouse model, the MMTV - Neu model of breast cancer progression and metastasis.

Shaw's research focuses on cancer metabolism: how metabolic pathways are altered in cancer and play a role in the origins and progression of the disease.

Thus, matriptase may play an important role in the progression of carcinomas, such as breast cancer.

Although further investigation regarding CSCs is still needed, there is evidence that these cells play an important role in the prognosis of cancer, progression, and therapeutic strategy.

Establishing the role of cigarette smoke in progression of cancer will not only produce the necessary evidence for implementing smoking cessation interventions but may also help to identify cellular mechanisms for therapeutic targeting.

Understanding the effects of Eph receptor mutations in cancer cells will help shed light on the role of the Eph receptor / ephrin system in cancer cell transformation, malignant progression and drug resistance.

The Center for RNA Interference and Non-Coding RNAs (RNA Center), established under the Red and Charline McCombs Institute for the Early Detection and Treatment of Cancer, is a unique collaborative initiative among MD Anderson Cancer Center, Baylor College of Medicine, the University of Texas Health Science Center at Houston, Rice University and the University of Houston that will focus on gaining insights into the roles of newly discovered RNAs in cancer initiation, progression and disseminCancer, is a unique collaborative initiative among MD Anderson Cancer Center, Baylor College of Medicine, the University of Texas Health Science Center at Houston, Rice University and the University of Houston that will focus on gaining insights into the roles of newly discovered RNAs in cancer initiation, progression and disseminCancer Center, Baylor College of Medicine, the University of Texas Health Science Center at Houston, Rice University and the University of Houston that will focus on gaining insights into the roles of newly discovered RNAs in cancer initiation, progression and dissemincancer initiation, progression and dissemination.

His laboratory has pioneered work on S100A7 and its role in breast cancer progression.

These data confirm that LARP7 protein levels are also reduced during breast cancer progression, and thus suggest that LARP7 may play a potential tumor suppressor role in breast cancer.

His laboratory is interested in understanding the role of metabolic adaptations in breast and prostate cancer progression, and elucidating mechanisms that promote therapy resistant aggressive metastatic disease.

Well, «[i] ncreasing evidence demonstrates the role that cholesterol... [may] play in the development and progression of breast cancer.»

Cholesterol may also play a role in the development and progression of breast cancer, as cancer appears to feed on it.

While that is a massive amount of colorectal cancer diagnoses each and every day, it's important to know that nutrition plays a major role in both the progression,... Read More»