Sentences with phrase «role in cell membranes»

They also have highly - specialized functions in neurological tissues, especially the brain and retina and play an important role in cell membranes and the formation of new tissue, therefore important for development and growth.

Choline's benefits are not just limited to maternal and infant health, and research shows that choline plays a critical role in cell membrane signaling, helps to regulate metabolism, and promotes liver and cardiac health across the lifespan.1

Not exact matches

The beta - carotene in pumpkin can help reverse UV damage and improve skin texture, and the abundant minerals in the orange fruit, including potassium, copper, manganese, zinc, iron and magnesium all play a role in the health and wellbeing of skin and hair, from collagen maintenance and cell membrane protection to healthy hair regrowth and skin cell regrowth.

Two protein receptors (yellow, red) float in a cell membrane's lipid rafts (orange), which play a role in antidepressants» delay.

«Lipids play a vital role in cellular function, because they form the membranes that surround each cell and many of the structures inside of it,» Quinlivan said.

The researchers tinkered with the voltage in cell membranes of developing African clawed frogs (Xenopus laevis) and found that electric charge plays a role in how big the brain grows and what kind of tissue developing cells grow into.

Stagljar and his colleagues also applied the new technology, which they dubbed MaMTH (for Mammalian - Membrane Two - Hybrid assay), to identify a protein that plays a role in the most common form of lung cancer called non-small cell lung cancer.

The lipid type, ceramide, also has a functional role in various signaling pathways and affects synaptic function, although its primary role is not in the synapse, but providing structure in cell membranes.

«Artificial fluorescent membrane lipid shows active role in living cells.»

It was clarified that GLUT4 with abnormalities in the N - glycan chain was transiently translocated to the cell membrane but was rapidly internalized without retention on the cell membrane, and that the N - glycan chain played a role in retaining GLUT4 on the cell membrane.

A receptor is a molecule placed on the cell membrane which, in some cases, can direct material from the surroundings to be taken up by the cell and degraded, In the degradation of bone tissue, the receptor uPARAP plays a central rolin some cases, can direct material from the surroundings to be taken up by the cell and degraded, In the degradation of bone tissue, the receptor uPARAP plays a central rolIn the degradation of bone tissue, the receptor uPARAP plays a central role.

Aquaporins have long been known to act as pores by transporting water across membranes in plants and animals, and they play critical roles in controlling the water content of cells.

Lipids have a variety of critical functions in all cells, including their role as the primary component of a cell's membrane.

To examine the role of soluble antibodies in the accumulation of MDSCs, they included an additional model of CLL in which B cells can only produce membrane - bound antigen receptors but not soluble antibodies.

But the researchers uncovered something more — that the business end of the syringe device serves a critical role in directing bacterial traffic, thus controlling whether the bacteria become «chronic dwellers» inside the membrane - bound vacuole or break out into the cell fluid.

It is still relatively unclear what role the biophysical properties of cell membrane play in this process.

Two - pore domain potassium channels (K2P) play a central role in the control of cellular excitability and the regulation of the cell's electrical membrane potential.

This small set of dynamic protein polymer systems underpins the establishment and remodelling of long range cellular order, cell polarity, shape and division, and plays a critical role in control of the dynamic organisation of the internal membrane - bound compartments that distinguish eukaryotes from their prokaryotic ancestors.

Starting my lab beginning of 2015 in Dresden we will focus on understanding the role of membrane organization during cell differentiation and tissue formation.

I became an eye researcher completely by accident while trying to unravel the role of a protein called Ankyrin in forming biological important membrane domains in cells, in this case, the photoreceptor.

Recently, Rothman and Südhof described the role of the Rab proteins and the SM (Sec1 / Munc18 - like) proteins in providing additional specificity and control to the process of SNARE scaffold assembly and vesicle docking to membranes in various cell types, thus confirming the general importance of these proteins (Science, vol 323, 23 January 2009).

Whether a protein is found in the nucleus, cell membrane, or mitochondria can provide clues to the protein's cellular role.

SLC16A11 belongs to a family of genes known to transport molecules across cell membranes, but the proteins that genes produce can perform many different roles in the body, and they can be active in some tissue types but not others.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in AML and breast cancer patients.10

Her lab also discovered that a component of the membrane that envelops the cell nucleus plays a key role in regulating the activity of brain cells.

External cues act on tyrosine kinase proteins embedded in the cell membrane to induce a cascade of signals with a vital role in regulating cell proliferation.

It plays an important role in keeping the integrity of the cell membrane and sustaining full cell cycle functionality.

Phosphatidylserine, as we mentioned before, is a part of the cell membrane and it plays a vital role in maintaining essential cellular functions, especially in brain cells.

The valuable vitamins and minerals provided by beets also play an important role in combating free radicals which can damage DNA and cell membranes.

Fat plays a big role in the construction of cell membranes and the sheaths surround nerves, while also being vital for blood clotting and inflammation.

Although there is little conclusive evidence at this point, some clues point to the fact that other mechanisms may also play a role in this fish oil / muscle anabolism connection, such as fatty acid concentration a in the cell membrane.

Not only is low cholesterol a problem, but it puts an individual at risk for viral infection, cancer, and mental illness because of the vital role that lipids play in cell membrane integrity, hormone production, and immunity.

* Free radicals damage cell membranes, tamper with DNA, and play a role in many health conditions.

The phospholipid phosphatidylcholine (lecithin) is the major dietary source of choline, a semiessential nutrient that is part of the B - complex vitamin family.1, 2 Choline has various metabolic roles, ranging from its essential involvement in lipid metabolism and cell - membrane structure to its role as a precursor for the synthesis of the neurotransmitter acetylcholine.

Arachidonic acid (AA) plays a role in the function of the brain, is a vital component of the cell membranes and is a precursor to important prostaglandins.

Choline also plays roles in gene expression and cell membrane signaling.

These fats keep our cell membranes healthy, reduce the risk for heart disease, and play other roles in the body.

Due to its impact on DNA, methylation plays a role in many other fundamental functions: creating the building blocks for DNA and RNA, hormones, neurotransmitters, cell membranes, protein synthesis, and others 2, 4.

Fats play a key role in hormonal production, and are an integral part of your cell membrane.

Healthy fats — such as the omega - 3 fatty acids in fish oils and nut oils — are a major part of brain cell membranes, and optimal levels can play a key role in protecting your brain.

So as you can see from its role in the cell's outer membrane, internal fluid, and genetic components, phosphorus is an essential part of the cell's design and it is a mineral that helps enable the cell's basic function.

Vitamin B6 plays a vital role in the multiplication of cells, making it very important for a healthy: pregnancy, immune system, mucous membranes and red blood cells.

Magnesium also plays a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction, and normal heart rhythm [3].

The membrane holds the intelligence of the cell and plays a major role in detox, turning genes on and off, regulating hormones, and is truly where healing begins.

Magnesium has been found to regulate and improve blood sugar control, play a vital role in the secretion and function of insulin, is necessary for insulin to open cell membranes for glucose and helps the body digest, absorb, and utilize proteins, fats, and carbohydrates.

Vitamin E's main role is to act as an antioxidant, preventing oxidative stress and protecting fatty acids in your cell membranes from free radicals (37).

Fats play a vital role in maintaining cell membranes across multiple body systems, by making up the coating around nerve cells, ensuring adequate cholesterol - based hormone production, maintaining a normal skin barrier, and aiding brain health.

These fatty acids play a vital role in the structure of cell membranes to support animals with skin health problems.

It also supplies essential fatty acids which play important roles in metabolism, cell membranes and skin permeability in pets..