Sentences with phrase «role in human disease»

As computational biologists, they employ comparative genomic approaches to understand the evolution and function of protein families and their ultimate role in human disease.

Arc is an activity - regulated neuronal protein, but little is known about its interactions, assembly into multiprotein complexes, and role in human disease and cognition.

His work focusses on the application of contemporary genomic technologies to detect genetic variation and evaluate its role in human disease.

Publication in Molecular Cell on reversal of base modifications in messenger RNA (mRNA) and role in human disease

In the past few years, whole - genome sequencing (WGS) studies performed in families (especially parent - child trios) have offered some revelations about de novo mutations and their role in human disease, notably that:

Now, a study published online April 27th, in the Journal of Immunology, confirms that the cytokine GM - CSF (Granulocyte macrophage colony - stimulating factor) likely plays an important role in human disease and offers a new explanation for why the MS treatment interferon - Beta (INF - β) is often effective at reducing MS attacks.

Androgen receptors are remarkable for their diversity of roles in human disease.

«Although I wholeheartedly agree that rare variants play a substantial role in human diseases, I also think that the section on GWAS reflects misunderstandings of the concept of GWAS, ignorance of standard practices in GWAS, misinterpretation of published primary research data, and as a result, is misinforming the general readership of Cell,» wrote Kai Wang, a postdoc at Children's Hospital of Philadelphia whose papers were cited in the Cell article.

Research suggests that random fluctuations in gene activity could explain some instances of the phenomenon, known as partial penetrance, which likely plays a role in some human diseases.

Not exact matches

What it does: The role of this bacteria, which is most well - known for causing syphilis and Lyme disease, is still not well - understood in humans.

According to the University of Maryland Medical Center polyunsaturated fatty acids (PUFAs)-- also known as omega - 3 fatty acids — play a crucial role in human brain function, as well as normal growth and development, with research showing that they can also reduce inflammation in addition to helping lower the risk of chronic diseases such as heart disease, cancer, and arthritis.

Human breast milk that is frozen or stored for longer than 48 hours loses a significant amount of its antioxidant content, making it less able to help infants fight off free radicals that play a role in allowing infections and other diseases.

Learn more about this topic in our essay Opening Pandora's Bread Box: The Critical Role of Wheat Lectin in Human Disease.

Besides DNA, entire mitochondria, mitochondrial proteins and mitochondrial RNA can also be found in the nucleus; but their roles in human health and disease remain relatively unexplored.

What is the role of the biomedical scientist amid the world's growing poverty crisis and the related human rights inequalities and the spread of diseases in underprivileged areas, The author provides examples of where the scientist can interface with human rights organizations, medical doctors, political and civic leaders, and the science - religion dialogue.

Since these behaviors are similar to behavioral traits in humans with schizophrenia, this suggests that KMO and KYNA may play a key role in the disease.

Since pseudouridine modifications may affect various RNA molecules in different types of normal and malignant cells, «our discoveries pave the way for future avenues of research aimed at exploring the role of pseudouridine in human development disease,» concludes Cristian Bellodi.

It is important for NASA to learn how bacterial communities that play roles in human health and disease are affected by spaceflight.

• In other funding news, the National Institutes of Health announced a new $ 17 million program to investigate whether extracellular RNA plays an important signaling role in people, and whether it can be harnessed to diagnose and treat human diseases, Mitch Leslie reports in News & AnalysiIn other funding news, the National Institutes of Health announced a new $ 17 million program to investigate whether extracellular RNA plays an important signaling role in people, and whether it can be harnessed to diagnose and treat human diseases, Mitch Leslie reports in News & Analysiin people, and whether it can be harnessed to diagnose and treat human diseases, Mitch Leslie reports in News & Analysiin News & Analysis.

The Duke medical researchers and ecologists who have joined that project hope to identify which species flourish in early stages of the human microbiome, how they are influenced by the consumption of breast milk, and what role they play in critical diseases affecting infants as well as in chronic diseases that occur later in life.

Human milk's most important role could be preventing infant disease and boosting immunity by cultivating a balance of microbes in the gut and the rest of the body, a kind of internal ecosystem called the microbiome.

In addition, the Izpisua Belmonte team is developing epigenetic editing technologies to reverse epigenetic alterations with a role in human aging and diseasIn addition, the Izpisua Belmonte team is developing epigenetic editing technologies to reverse epigenetic alterations with a role in human aging and diseasin human aging and disease.

If there is anything scientists are certain of when it comes to bats and their supposed role in causing human disease, it is that they still have a lot to learn.

«We leveraged the extreme traits in different species to uncover noncoding regions in the human genome that likely have important roles in shaping health and disease,» said Elliott Ferris, first author on the paper and a bioinformatician and computer programmer in Gregg's lab.

«Thus, it is clear that further studies must investigate an increasingly complex matrix of cell types and conditions to fully understand the role of human genetic variation in disease.»

«Understanding this previously ignored part of the human genome, its role in human development, and how it may be taken over by disease, opens a new frontier in science with important implications for medical advances,» said Philipp Kapranov, Ph.D., lead researcher at the St. Laurent Institute.

«The project has made important new contributions towards describing the role of rare genetic variants in a broad range of disease scenarios and human traits.»

Up to 98 percent of human genomic matter is known as «junk» or «dark matter» non-coding DNA, and had for years attracted little interest among scientists who doubted its role in human health and disease.

«We are only beginning to understand the role that human - made chemicals play in causing human disease,» said Regnier.

The hormone estrogen plays an important role in the human body and has been linked to everything from tumor growth to neuron loss during Alzheimer's disease.

«Tiny mitochondria play outsized role in human evolution and disease.»

While genetics play a role in the development of Lupus, a systemic autoimmune disease that can attack any organ system in the human body, so do environmental triggers, such as particulates in air pollution and ultraviolet light, explains Gaurav Gulati, MD, a physician - researcher at the University of Cincinnati (UC) College of Medicine.

Though mutations that cause human cancer have traditionally been thought to originate from heredity or environmental sources, these results — grounded in a novel mathematical model based on data from around the world — support a role for so - called «R» or random mutations in driving the disease.

Transport of engineered nano - particles loaded with drugs or bio-molecules to the site of the disease in pathophysiologic states in humans plays a critical role in determining the efficacy of therapeutic management.

This suggests that ATP7B and ATP7A play antagonistic roles in copper homeostasis, and that attenuation of copper accumulation by mutation of ATP7A could ameliorate symptoms of Wilson disease in humans.

The Simon lab is now working on testing the effects of the chimera on human liver cells and in mouse livers, to further elucidate its role in the disease.

By building this selective set of compounds and making it freely available, UNC - Chapel Hill and its partners are offering the scientific community a better understanding of the roles the kinome plays in human disease and the ability to collaborate on the discovery and advancement of new therapies.

In addition to their role in ecosystems, amphibians also help humans by controlling insect populations — including the mosquitoes that spread diseases like Zika and dengue feveIn addition to their role in ecosystems, amphibians also help humans by controlling insect populations — including the mosquitoes that spread diseases like Zika and dengue fevein ecosystems, amphibians also help humans by controlling insect populations — including the mosquitoes that spread diseases like Zika and dengue fever.

Given that adipose tissue (which makes up between 15 and 20 % of the body weight in healthy people) is a source of inflammation in obese individuals, Christine Bourgeois and Olivier Lambotte, from the University Paris SUD, France, and colleagues, decided to investigate a possible role of the adipose tissue in humans infected with HIV and in macaques infected with simian immunodeficiency virus (SIV, an HIV relative that causes AIDS - like disease in some non-human primates).

A new study has found that nearly half of camels in parts of Kenya have been infected by the virus that causes Middle East Respiratory Syndrome (MERS) and calls for further research into the role they might play in the transmission of this emerging disease to humans.

Almost 100 trillion microbes — some beneficial and some harmful — live in the human gastrointestinal tract at any time, helping to regulate immune function and inflammation, two factors hypothesized to play a role in neurodegenerative diseases like Parkinson's and Alzheimer's.

This discovery plays a primordial role in understanding immune system diseases in humans.

Scientists are only beginning to understand what role the billions of microbial cells colonizing the human gut play in diet and disease.

«This work in lower species of organisms does not have an impact on the understanding of the role of sirtuins in human health and disease.»

Next - generation sequencing — the ability to sequence millions or billions of small fragments of DNA in parallel — has revolutionized the biological sciences, playing an essential role in everything from locating mutations that cause human disease to determining how a newly discovered animal fits into the tree of life.

The Wnt pathway is found throughout the animal kingdom — from sponges to humans — and it plays a fundamental role in animal development and disease.

«The dramatic increase in these diseases has occurred amidst constant human genetics, suggesting a pivotal role for an environmental factor,» said Chassaing, assistant professor in the Institute for Biomedical Sciences.

Although CLP1 mutations have been linked to neuronal death and motor defects in mice, the role of CLP1 in human disease was not known until now.

A human protein known as prohibitin may play a significant role in infection of the nervous system by EV71, one of several viruses that can cause hand, foot, and mouth disease.

«We would also now like to broaden this research to see how much this process may play a similar role in other major human diseases.»