Sentences with phrase «role in metabolism regulation»

Not exact matches

Building upon their earlier research on the biology of fat metabolism, Joslin scientists discovered that microRNAs - small RNA molecules that play important roles in regulation in many types of tissue — play a major role in the distribution and determination of fat cells and whole body metabolism.

The Lazar lab has been working on HDAC3 for over a decade, focusing on the pivotal role of this enzyme in hormone - mediated regulation of gene expression and metabolism.

In a non-disease state, TDP - 43 is an important protein involved in various aspects of the metabolism of RNA, a molecule essential in various biological roles in the regulation and expression of geneIn a non-disease state, TDP - 43 is an important protein involved in various aspects of the metabolism of RNA, a molecule essential in various biological roles in the regulation and expression of genein various aspects of the metabolism of RNA, a molecule essential in various biological roles in the regulation and expression of genein various biological roles in the regulation and expression of genein the regulation and expression of genes.

He led the Glaxo program on orphan nuclear receptors that uncovered their role in regulation of human metabolism and was co-discoverer of obeticholic acid, a breakthrough medicine for liver diseases targeting FXR.

Also in humans, both insulin and leptin play important roles in regulation of energy metabolism and body weight via central and peripheral effects.

The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium / phosphate homeostasis.

HIF - 1 plays important roles in critical aspects of cancer biology, including tumor angiogenesis, regulation of glucose and energy metabolism, invasion, and metastasis.

Edward Bullmore, UK Robert Dow, UK Garrett Fitzgerald, USA - Prostanoid biology and the role of peripheral molecular clocks in cardiovascular biology, metabolism and aging Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Patrick du Souich, Canada - Cytochrome P450, membrane carriers, disease, inflammation, rational use of drugs, clinical pharmacology David J. Webb, UK - hypertension, chronic kidney disease, endothelial function and dysfunction, arterial stiffness, health technology assessment, medicines regulation Don Birkett, Australia - Clinical pharmacology / pharmacokinetics and drug utilisation

Finally, we generated a mouse model to assess the role of PRCP in NPY / AgRP neurons of the arcuate nucleus in the regulation of metabolism.

EFAs or essential fatty acids play a very important role in different body functions like cell maintenance, brain development, transportation of oxygen from the lungs to the bloodstream, regulation of metabolism and mood, regulation of insulin sensitivity, as well as hormone production.

Water plays a key role in metabolism and regulation of your body's homeostatic mechanisms.

More than one hundred vitamin B6 - dependent enzymes have been identified, mostly involved in amino acid metabolism: for oxygen transport via hemoglobin synthesis; in blood sugar regulation via conversion of stored carbohydrate to energy; in the development of the myelin sheath surrounding nerve cells; in the conversion of alphalinoleic acid to the essential long - chain fatty acid DHA; 28 and in the synthesis of neurotransmitters, phospholipids and sphingolipids, the vitamin niacin from tryptophan, and other vital metabolites.5 In addition to its role in enzyme reactions, B6 appears to moderate the action of some steroid hormones such as the glucocorticoid hormones, which in turn influence the metabolism of protein, carbohydrate and lipids.5, 9 B6 also is a potent antioxidant, rivaling carotenoids and vitamin E in its ability to quench reactive oxidants in the body.in amino acid metabolism: for oxygen transport via hemoglobin synthesis; in blood sugar regulation via conversion of stored carbohydrate to energy; in the development of the myelin sheath surrounding nerve cells; in the conversion of alphalinoleic acid to the essential long - chain fatty acid DHA; 28 and in the synthesis of neurotransmitters, phospholipids and sphingolipids, the vitamin niacin from tryptophan, and other vital metabolites.5 In addition to its role in enzyme reactions, B6 appears to moderate the action of some steroid hormones such as the glucocorticoid hormones, which in turn influence the metabolism of protein, carbohydrate and lipids.5, 9 B6 also is a potent antioxidant, rivaling carotenoids and vitamin E in its ability to quench reactive oxidants in the body.in blood sugar regulation via conversion of stored carbohydrate to energy; in the development of the myelin sheath surrounding nerve cells; in the conversion of alphalinoleic acid to the essential long - chain fatty acid DHA; 28 and in the synthesis of neurotransmitters, phospholipids and sphingolipids, the vitamin niacin from tryptophan, and other vital metabolites.5 In addition to its role in enzyme reactions, B6 appears to moderate the action of some steroid hormones such as the glucocorticoid hormones, which in turn influence the metabolism of protein, carbohydrate and lipids.5, 9 B6 also is a potent antioxidant, rivaling carotenoids and vitamin E in its ability to quench reactive oxidants in the body.in the development of the myelin sheath surrounding nerve cells; in the conversion of alphalinoleic acid to the essential long - chain fatty acid DHA; 28 and in the synthesis of neurotransmitters, phospholipids and sphingolipids, the vitamin niacin from tryptophan, and other vital metabolites.5 In addition to its role in enzyme reactions, B6 appears to moderate the action of some steroid hormones such as the glucocorticoid hormones, which in turn influence the metabolism of protein, carbohydrate and lipids.5, 9 B6 also is a potent antioxidant, rivaling carotenoids and vitamin E in its ability to quench reactive oxidants in the body.in the conversion of alphalinoleic acid to the essential long - chain fatty acid DHA; 28 and in the synthesis of neurotransmitters, phospholipids and sphingolipids, the vitamin niacin from tryptophan, and other vital metabolites.5 In addition to its role in enzyme reactions, B6 appears to moderate the action of some steroid hormones such as the glucocorticoid hormones, which in turn influence the metabolism of protein, carbohydrate and lipids.5, 9 B6 also is a potent antioxidant, rivaling carotenoids and vitamin E in its ability to quench reactive oxidants in the body.in the synthesis of neurotransmitters, phospholipids and sphingolipids, the vitamin niacin from tryptophan, and other vital metabolites.5 In addition to its role in enzyme reactions, B6 appears to moderate the action of some steroid hormones such as the glucocorticoid hormones, which in turn influence the metabolism of protein, carbohydrate and lipids.5, 9 B6 also is a potent antioxidant, rivaling carotenoids and vitamin E in its ability to quench reactive oxidants in the body.In addition to its role in enzyme reactions, B6 appears to moderate the action of some steroid hormones such as the glucocorticoid hormones, which in turn influence the metabolism of protein, carbohydrate and lipids.5, 9 B6 also is a potent antioxidant, rivaling carotenoids and vitamin E in its ability to quench reactive oxidants in the body.in enzyme reactions, B6 appears to moderate the action of some steroid hormones such as the glucocorticoid hormones, which in turn influence the metabolism of protein, carbohydrate and lipids.5, 9 B6 also is a potent antioxidant, rivaling carotenoids and vitamin E in its ability to quench reactive oxidants in the body.in turn influence the metabolism of protein, carbohydrate and lipids.5, 9 B6 also is a potent antioxidant, rivaling carotenoids and vitamin E in its ability to quench reactive oxidants in the body.in its ability to quench reactive oxidants in the body.in the body.29

Arginine may also play a role in the regulation of fat metabolism, perhaps through up - regulation of mitochondrial and brown adipose tissue activity, improving our bodies» fat - burning capacities, which help maintain a healthy weight.

In just the past year, there have been several significant studies about magnesium's role in keeping your metabolism running like a well - oiled clock — specifically in terms of insulin sensitivity, glucose regulation, and protection from type 2 diabeteIn just the past year, there have been several significant studies about magnesium's role in keeping your metabolism running like a well - oiled clock — specifically in terms of insulin sensitivity, glucose regulation, and protection from type 2 diabetein keeping your metabolism running like a well - oiled clock — specifically in terms of insulin sensitivity, glucose regulation, and protection from type 2 diabetein terms of insulin sensitivity, glucose regulation, and protection from type 2 diabetes.

Our circadian clock plays a major role in metabolism, blood pressure regulation, and hormone secretion.

It is incorporated into key enzymes involved in several metabolic pathways implicated in thyroid hormone metabolism; additionally, it plays an antioxidant role in the regulation of the immune system.

Fats play a vital role in not only energy production and fat metabolism, but also in hormone regulation especially during dieting.Be sure to include some fats into your eating plan such as whole eggs, avocado, nuts (almonds and walnuts), natural peanut and almond butter and olive oil.

They play a significant role in the regulation of fat metabolism, glucose, and insulin.

GLA plays a role in hormone production, fat metabolism and insulin regulation.

The role of leucine in the regulation of protein metabolism.

These two conventional nutrients play a critical role in our body's regulation of oxygen metabolism, and they are widely known for their role in helping lower our risk of oxidative stress.

• Help regulate oxygen uses and energy production • Important in nerve, muscle and cellular functions • Play a vital role in cognitive function, including memory and mood • Involved in regulation of metabolism, body temperature, blood sugar and insulin control, thyroid function, carbohydrate metabolism and control over hormonal processes • Lubricate joints and improve mineralization of bones • Help transport cholesterol • Improve digestion of the gut • Build the immune system and regulate inflammatory response • Can help direct the processes that stimulate fat breakdown and utilization • Helps regulate blood pressure

A Scientific Review: The Role of Chromium in Insulin Resistance The Diabetes Educator 2004; Suppl: 2 — 14 Chromium is an essential mineral that appears to have a beneficial role in the regulation of insulin action and its effects on carbohydrate, protein and lipid metabolRole of Chromium in Insulin Resistance The Diabetes Educator 2004; Suppl: 2 — 14 Chromium is an essential mineral that appears to have a beneficial role in the regulation of insulin action and its effects on carbohydrate, protein and lipid metabolrole in the regulation of insulin action and its effects on carbohydrate, protein and lipid metabolism.

The understanding of phytosterols and the role of these lipids in drug therapy such as cholesterol lowering drugs may provide molecular mechanisms that are involved in the regulation of cell Aβ clearance and metabolism.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseaseIn addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein the treatment of convulsion diseases.