Sentences with phrase «role in tumor»

Moreover, research demonstrates that natural progesterone can play an important role in tumor reduction.

Because programmed cell death goes awry in leukemias and other cancers, Hu is currently examining lincRNA - EPS's function in normal and diseased human cells in an effort to determine whether it plays a role in tumor development and growth.

Laboratory research from the University of Chicago Medicine and a genetic study from the University of North Carolina Medical Center both argue that the mu opioid receptor plays an important role in tumor progression and support a therapeutic role for opioid antagonists.

Epigenetic alterations play a crucial role in tumor progression.

Cellular senescence is a major contributor to tissue aging and plays a context - dependent role in tumor development.

These signaling molecules may also play a role in tumor development in other organs, and are being evaluated in melanoma and other tumor types.

«I am thrilled to have made a difference in the lives of cancer patients and to be recognized by fellow scientists for my part in the discovery of the PD - 1 / PD - L1 and PD - L2 pathway and its role in tumor immune evasion.

Among the 108 genomes assessed, there were 23 genes harboring non-silent mutations in at least three independent tumors, suggesting an important role in tumor development or growth.

We conclude that p21 plays a significant role in tumor suppression, which is more important than that of Bax but weaker than that of p53 or its upstream regulators ATM and p19ARF.

As an assistant professor at the Boston University Medical School, she became interested in the control of cellular senescence and its role in tumor suppression and aging.

Therefore, mutation (s) in alternate reading frame protein dysregulate p53 function and play a role in tumor immune evasion.

The researchers discovered a single letter variant located in TP53, a gene known to play a central role in tumor biology and for accumulating so called somatic mutations, during the development of cancer in patients.

As important mediators of cell adhesive behavior, integrins play a critical role in tumor progression and metastasis.

«It was surprising to find that LECs can play such an active and significant role in tumor spread.»

Investigators found that NPTX2 was expressed in all stages of kidney cancer, especially metastasis, which suggests it plays an important role in tumor development and progression.

This lengthy period of time, compared to a mouse's lifetime, indicates that additional factors play a role in tumor development.

Although these mutations are thought to initiate colorectal cancer, it has not been clear whether Apc inactivation also plays a role in tumor growth and survival once cancer has already developed.

Although BRCA1's role in tumor initiation is well known, the fact that it also seems to be involved in tumor progression comes as a surprise, says Eliot Rosen, a molecular biologist at Georgetown University in Washington, D.C.

After identifying FAK's role in tumor development, François started looking for ways to get it in check.

MDSCs are immune cells originating from bone marrow stem cells that possess strong immunosuppressive abilities and are known to play a role in tumor formation and metastasis.

A form of genetic variation, called differential RNA splicing, may have a role in tumor aggressiveness and drug resistance in African American men with prostate cancer.

These findings also have implications for treatment of cancer and other disorders, such as obesity, in which M2 macrophage cells play a regulatory role in tumor growth and fat deposition.

Correspondingly, a large number of genes with no direct role in tumor progression also are deleted as a result of their proximity to tumor suppressor genes.

Therefore, miRNA network is considered to play critical roles in tumor initiation and progression.

Not exact matches

He had temporarily stepped down from his CEO role in November after a tumor appeared.

Prior to this role, Derek was a Senior Associate on the Landscape Team within the TechAtlas division of RA Capital, where he mapped competitive landscapes in the solid tumor oncology space and performed in - depth analyses of pharma pipelines.

This observation has implications for understanding the role of EGFR in capsaicin - mediated survival of tumors.

«We also confirmed a role in PDAC tumor maintenance as inhibition of PRMT1 in patient - derived mouse models significantly inhibited tumor growth and extended survival,» said Giuliani.

In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activitIn this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activitin which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activitin high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activitin preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activity.

to better understand the role they have in tumor progression.

In the Journal of Biological Chemistry, the scientists demonstrate that the protein ZEB1 plays a particularly important role: It limits the production of the binding proteins E-cadherin and Epcam — both in the fish embryo and in the tumor celIn the Journal of Biological Chemistry, the scientists demonstrate that the protein ZEB1 plays a particularly important role: It limits the production of the binding proteins E-cadherin and Epcam — both in the fish embryo and in the tumor celin the fish embryo and in the tumor celin the tumor cell.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.

«Mus81 really does play a critical role» in suppressing tumors, says Stephen West, a biochemist at Cancer Research UK in London.

Although normal inflammation plays an important role in helping to fight off infections, there is mounting evidence that chronic inflammation is linked to increased risk of tumor development.

DAP12 plays a critical role in activating the NK cells» cytotoxic pathways; therefore, lower levels of DAP12 in NK cells results in a reduced ability to target tumor cells.

A rare - stem like tumor cell, which plays a critical role in the spread of breast cancer, is identified with immunostaining for the?

Their study, in the journal Oncotarget, is the most extensive analysis to date of gene expression's role in ccRCC tumor growth and metastasis.

Indeed, tumors contain a lot of specific macrophages that play a decisive role in the formation of blood vessels.

Rare stem - like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.

In an article titled, «Allergen Induced Pulmonary Inflammation Enhances Mammary Tumor Growth and Metastasis: Role of CH13L1,» featured on the cover of the current issue of the Journal of Leukocyte Biology, this new research suggests inflammation raises the level of a known biomarker of cancer, called «chitinase -3-like-1» or «CHI3L1,» in the inflamed tissue, which leads to increased metastasis and faster cancer growth in that tissuIn an article titled, «Allergen Induced Pulmonary Inflammation Enhances Mammary Tumor Growth and Metastasis: Role of CH13L1,» featured on the cover of the current issue of the Journal of Leukocyte Biology, this new research suggests inflammation raises the level of a known biomarker of cancer, called «chitinase -3-like-1» or «CHI3L1,» in the inflamed tissue, which leads to increased metastasis and faster cancer growth in that tissuin the inflamed tissue, which leads to increased metastasis and faster cancer growth in that tissuin that tissue.

«We conclude that KIF1B - β plays a key role in the decision between life and death for neural crest cells and tumors originating from the neural crest,» says Susanne Schlisio.

Cheng and colleagues did experiments using human cells and identified hnRNPM's role in controlling the processes linked to tumor metastasis.

In the present study, the researchers take a closer look at the role of Numb in these tumorIn the present study, the researchers take a closer look at the role of Numb in these tumorin these tumors.

The researchers identified a genetic mutation in the tumor cells that plays a role in both the growth and the death of a cell.

The research team behind the new study previously discovered that genes mutated in some of the tumors play a central role in determining whether neural crest cells live or die.

In a previous study, his team worked with other collaborators to identify the potential role of extra copies of the tumor suppressor gene (p53) that increase the elephant's ability to eliminate pre-cancerous cells with DNA damage.

«This is the first time the 3 - D culturing method has been used to predict the effectiveness of different drugs on tumors from individual patients,» said graduate student Alex Walsh, who has played a key role in developing the test.

«This is the best example that NF1 is a tumor suppressor,» says David Viskochil, a geneticist at the University of Utah, although he cautions that the case is not yet closed: There still could be other genes that play a role in NF tumor development.

Researchers have identified a group of immune system genes that may play a role in how long people can live after developing a common type of brain cancer called glioblastoma multiforme, a tumor of the glial cells in the brain.