Sentences with phrase «role of adaptive immunity»
«Recent successes in cancer immunotherapy — in the form of immune checkpoint inhibitors and adoptive T cell transfer — demonstrate how activated immune cells can eradicate tumors, but until now we didn't fully appreciate immunosurveillance or the role of adaptive immunity in tumor formation,» said senior author Michael Karin, PhD, Distinguished Professor of Pharmacology and Pathology at UC San Diego School of Medicine.
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Key outstanding questions regarding CRISPR - Cas biology include the ecological roles of microbial adaptive immunity, the high rates of CRISPR - Cas horizontal transfer, and the coevolution of CRISPR - Cas and phage - encoded anti-CRISPR proteins.
In his current position, he studies the role of interferon - regulatory factors in the regulation of innate and adaptive immunity, in collaboration with Tadatsugu Taniguchi.
The main mechanism includes phagocytosis of macrophages which play a critical role in nonspecific defense (innate immunity) and, moreover; they have a role as antigen presenters which also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes.
Dr. Barrangou and colleagues at DuPont established the biological role of CRISPR - Cas systems in adaptive immunity in bacteria, and used CRISPR - based technologies for bacterial genotyping of industrial cultures, and for the vaccination of dairy cultures against bacteriophages.
Interleukin 15 (IL - 15) regulates the development, survival, and functions of multiple innate and adaptive immune cells and plays a dual role in promoting both tumor cell growth and antitumor immunity.