Sentences with phrase «role of endothelial cells»

Yet, more recent discoveries suggest a much more active role of endothelial cells during tumor growth than has been anticipated so far.

Not exact matches

In their latest study, Guarente and his colleagues decided to explore the role of sirtuins in endothelial cells, which line the inside of blood vessels.

Luster's team hopes to further investigate the characteristics of joints that underlie the critical role of C5a in initiating type III hypersensitivity and whether specific molecules expressed on endothelial cells lining joints play a role in transporting C5a and chemokines from the joint space into adjacent blood vessels.

«Endothelial cells play a very important role in multiple steps of many diseases, from initiation to the onset of clinical complications,» says Aikawa, who was not part of the research team.

To explain their findings, the authors suggest that resveratrol's vasodilating effects via endothelial cells might enhance infiltration of inflammatory cells into the central nervous system, which in turn might play a key role in the pathogenesis of MS.

Specifically, they were able to determine that Wars2 plays an important role in supplying sufficient endothelial cells, the building blocks of blood vessels, for angiogenesis.

Given that endothelial cells play a central role in several rate - limiting steps of metastasis, the interactions that take place between tumor cells and endothelial cells have been the focus of much investigation.

Endothelial progenitor cells (EPCs) differentiate into the cells that make up the lining of blood vessels, and so play roles in vasculogenesis and angiogenesis.

With potential therapeutic implications, Stainier and a colleague also recently discovered that endothelial cells, which line the blood vessels, play a critical role in inducing the development, or proper differentiation, of red blood cells, the transporters of oxygen.

More recently, we have started to investigate the role of arachidonic acid P450 epoxygenases in the control of endothelial cell function in vitro and tumorigenesis in vivo.

In the past 10 years our laboratory has investigated the role of cell - matrix interaction in the control of endothelial cell functions in vivo and in vitro and provide the first evidence that the collagen binding integrin alpha1beta1 is pro-angiogenic and pro-tumorigenic and its inhibition and / or down - regulation is beneficial in the setting of tumor associated angiogenesis.

The Role of MGAT5 in Human Umbilical Vein Endothelial Cells Possible Relevance to the Pathological Mechanism of Preeclampsia.

Endothelial cells play a major role in the development and differentiation of the vascular system.

Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin - 1

Chairs: Rama Natarajan, Beckman Research Institute of City of Hope and Marianne Grant, Beth Israel Deaconess Medical Center Philip Marsden, University of Toronto Epigenetic regulation of endothelial phenotype: the role of the non coding genome Kathleen Martin, Yale School of Medicine Transcriptional and epigenetic regulation in vascular smooth muscle cells

Chairs: Jozef Dulak, Jagiellonian University and Shahin Rafii, Weill Cornell Medical College Karen K. Hirschi, Yale School of Medicine Role of vascular endothelial cells in stem cell generation and maintenance Ann Zovein, University of California, San Francisco Cell fate decisions in hemogenic endothelium (Stem Cells I under Cells and Vascular cells in stem cell generation and maintenance Ann Zovein, University of California, San Francisco Cell fate decisions in hemogenic endothelium (Stem Cells I under Cells and Vascular Bcell generation and maintenance Ann Zovein, University of California, San Francisco Cell fate decisions in hemogenic endothelium (Stem Cells I under Cells and Vascular BCell fate decisions in hemogenic endothelium (Stem Cells I under Cells and Vascular Cells I under Cells and Vascular Cells and Vascular Beds)

These scientific goals guide our efforts at determining the role and mechanisms of the stromal cells, including the fibroblasts, endothelial and lymphatic elements, the matrix and the inflammatory / immune cells as critical targets for therapeutic intervention.

From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.

«Schlemm's canal endothelial cells are believed to be one of the resistance sites crossed by the aqueous humor before entering the blood circulation and are likely to play an important role in the regulation of aqueous humor outflow resistance.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

Endothelial cells line the walls of the body's entire circulatory system, from the arterial walls of the heart to the smallest, most vulnerable capillaries — and their role in heart health is critical.

Effect of Alpha - lipoic Acid on the Progression of Endothelial Cell Damage and Albuminuria in Patients with Diabetes Mellitus: An Exploratory Study Diabetes Res Clin Pract 2001 (Jun); 52 (3): 175 — 183 Oxidative stress plays a central role in the pathogenesis and progression of late microangiopathic complications (diabetic nephropathy) in diabetes mellitus.

Vascular endothelial cells play an important role in the regulation of vascular activity by producing vasoactive substances such as NO.