Understanding
the role of glial cells in glaucoma as well as what happens to the optic nerve where the retinal nerve axons leave the eye may present new therapeutic targets and even potential biomarkers of glaucoma.
Until recently it has been difficult to study
the role of glial cells in controlling appetite or any other brain function, because scientists haven't developed many techniques for silencing or stimulating these cells, as they have for neurons.
Not exact matches
Future studies will look at the
role p75 plays in two other types
of cells —
glial cells and skin
cells.
Researchers have identified a group
of immune system genes that may play a
role in how long people can live after developing a common type
of brain cancer called glioblastoma multiforme, a tumor
of the
glial cells in the brain.
A depiction
of the brain
glial cell response towards site injury upon insertion
of neural interface probe track (rectangular hole), which disrupts the maintenance
of their important regulatory
roles.
Kozai's lab is currently working with Franca Cambi, professor
of neurology at Pitt, on a project to understand the
role of another type
of glial cell on brain injury and neuronal activity.
«The most obvious function
of glial cells has been related to their
role in forming scar tissue to prevent the spread
of injury and neuronal degeneration, but so much about their
role in the brain is unknown.»
Human stem / progenitor
cells from bone marrow enhance
glial differentiation
of rat neural stem
cells: a
role for transforming growth factor β and Notch signaling.
Altogether, these findings highlight the central
role of Lkb1 during neural crest
cell lineage and uncovered a link between Lkb1 - mediated pyruvate - alanine cycling and
glial commitment.
To determine the
role of inflammatory response in the pathophysiology
of these diseases,
glial cell morphology and essential functions, such as glutamate transport, ion recapture and modulation
of neurotransmission will be evaluated following infusion
of autoantibodies in the hippocampus.
The potential for
cell therapy to play a
role in the therapy
of myelin disorders is under serious consideration, based on years
of experimentation
of glial cell transplants in experimental models.
[32 - 34] And recently, emerging evidence has pointed to an important indirect
role played by senescent
cells (specifically, senescent
glial cells) in PD, contributing to the dysfunctional neuroinflammation and SN DA neuron loss in PD, [35] and researchers are now reporting the salutary effects
of their therapeutic clearance.
Contrary to mainstream research, our experimental approach steadily provided data that, with time, lead to a diffused awakening
of the scientific community:
glial cells can potentially play an enormous
role in the pathophysiology
of the brain.
Our track record shows that NeuroGLIA members are at the forefront
of glial cell research, and can thus be reasonably expected to be in a privileged position to formulate hypotheses and design new experiments that will increase our comprehension
of the
role of astroglia in the brain.
Their findings show that the special
glial cells help synapses grow and rearrange, demonstrating the essential
role of microglia in brain development.
There was also a Special Interest Group on «The
Role of Astrocytes and Other
Glial Cells in Retinal Function and Glaucoma.»