Sentences with phrase «roles in different cells»

Not exact matches

Jason Mills, a gastrointestinal pathologist at Washington University School of Medicine in St. Louis, envisions growing thousands of such organoids, each from a different person's cells, and infecting them with a pathogen to study the role of individual genetics.

«Now that we've confirmed the human relevance of our findings, our future goal is to better understand the roles of the different cell types in psychiatric and neurological disorders, and to determine if targeting these cells can actually help treat seizures,» concluded Paz.

This finding reinforced the notion that, in addition to their distinct physiological functions, the two cell types have very different roles in disease.»

This system plays a major role in the regulation of gene activity, and enables the selective expression of different functions in differentiated cell types.

Since pseudouridine modifications may affect various RNA molecules in different types of normal and malignant cells, «our discoveries pave the way for future avenues of research aimed at exploring the role of pseudouridine in human development disease,» concludes Cristian Bellodi.

«Previous studies have shown that heparan sulfate plays a role in the cells» uptake of different viruses, such as HIV and the herpes simplex virus.

Although blood cells serve multiple roles in the body and have complex interactions with other cellular materials, most synthetic blood products have aimed to just stick to the bare basics — shuttling oxygen from the lungs to different vital organs and then bringing carbon dioxide back to the lungs to be exhaled.

Scientists know that different auxin concentrations in cells and their environment assume a key role in these differentiation processes.

The newly unmasked genes play a role in three distinctively different bodily functions, including systems that control inflammation and cholesterol and the regulation of how brain cells clean up toxic proteins.

The study goal was to determine if these different trajectories were associated with blood concentrations of eosinophils and neutrophils, two types of immune cells that play a role in many respiratory diseases and are routinely measured during medical evaluations.

As another advantage, APC - mimetic scaffolds enabled us to tune the ratios of subpopulations of T cells with different roles in the desired immune responses, which in the future might increase their functionality,» said David Zhang, the study's second author and a Graduate Student working with Mooney.

Research from Rutgers Cancer Institute of New Jersey shows that the RUNX2 protein, which regulates the transcription of genetic messages responsible for the different functions of cells, may play a role in melanoma cell growth and spread and could serve as a therapeutic target for the disease.

It plays an important role in how cells sense their neighbors and, by controlling gene expression, determines which cells should develop into different types and how much they should grow - like a master controller.»

The researchers also note that more investigation is needed to fully understand all the mechanisms by which HOXC10 mediates cell proliferation and death, and the roles it may play in different types of tumors.

Ten years ago, convinced that bioelectricity plays an important role in development, Levin and his colleagues systematically altered the number of ion channels in cells in different parts of a frog embryo.

The inhibition is regulated by different molecules in animals and plants,» explains NAIST Professor Masaaki Umeda, who studies the role of stem cells in plant growth.

Our bodies are made of more than 10 trillion cells of hundreds of different kinds, each of which plays its unique role in keeping us alive and healthy.

Christian Seiser says: «Our results highlight that it is crucial to understand the individual role the various HDAC variants in different cell types and hence different types of cancer, before HDAC inhibitors can be used safely as therapeutics.»

It plays a pivotal role in the orderly evolution of different types of animal cells.

The team discovered that the TCL1 protein played a key role in increasing glycolysis by activating a different metabolic pathway that is important for the self - renewal of stem cells.

Scientists have already seen the same mark close to the start of active genes in many cells, but the team discovered that its role in egg cells is different.

«We think that its partner in this case, mGluR5, may also play a role of previously unrecognized breadth, acting within many different types of cells to intensify signals, such as those transmitted by GABA, glutamate, or other neurotransmitters,» Kim adds.

Such differences may enable each individual actin form to take on a different role in the cell.

Some evidence indicated that basophils play a role in tick resistance, but other research pointed to different cells called mast cells.

In the new study, the researchers explored the role of cell shape in two vastly different types of epithelial cells — human bronchial epithelial cells grown in the lab and cells within the living embryo of the fruit fly — and observed them as they matured over timIn the new study, the researchers explored the role of cell shape in two vastly different types of epithelial cells — human bronchial epithelial cells grown in the lab and cells within the living embryo of the fruit fly — and observed them as they matured over timin two vastly different types of epithelial cells — human bronchial epithelial cells grown in the lab and cells within the living embryo of the fruit fly — and observed them as they matured over timin the lab and cells within the living embryo of the fruit fly — and observed them as they matured over time.

The group hypothesized that MTs and F - actin play different roles in the zygote due to their different alignment in the cell.

But how do cells «know» what role they have in the body; for example, how is a liver cell so different from a white blood cell?

Together with the more studied regulatory T cells (Tr1 and CD25 + FOXP3 + Treg), growing evidence indicates that different subsets of dendritic cells (DC), play a critical role in promoting immune tolerance.

With only a single gene and a toolbox of forward and reverse genetic approaches at hand, C. elegans offers an opportunity to explore the exact role of perlipin - related factors in fat regulation throughout development of many different somatic and germline cells.

We investigated the role of Srf in two cellular compartments of mouse skeletal muscle (myofibers and adult muscle stem cells) upon different perturbation of muscle homeostasis (hypertrophy, atrophy, regeneration).

In the COBRE for Stem Cell Biology, Brown and Rhode Island Hospital researcher Dr. Jason Aliotta is studying the role, for better and for worse, of different extracellular vesicles — blobs of material shed by cells — in mediating the production of harmful cells in bone marroIn the COBRE for Stem Cell Biology, Brown and Rhode Island Hospital researcher Dr. Jason Aliotta is studying the role, for better and for worse, of different extracellular vesicles — blobs of material shed by cells — in mediating the production of harmful cells in bone marroin mediating the production of harmful cells in bone marroin bone marrow.

July 2009 - Switching on the power of stem cells Cambridge scientists reveal how the protein Nanog gives stem cells their unique abilities Researchers from the Wellcome Trust Centre for Stem Cell Research at the University of Cambridge have pinpointed the role of the protein Nanog in a complex process that gives stem cells pluripotency: the ability to produce all the different cell types of the bCell Research at the University of Cambridge have pinpointed the role of the protein Nanog in a complex process that gives stem cells pluripotency: the ability to produce all the different cell types of the bcell types of the body.

B cells (bursal or bone marrow - derived cells) are lymphocytes that play a pivotal role in the adaptive immune system and disruption of B cell function is a common hallmark of many different diseases.

Ion channels play a critical role in physiology and many different biological processes such as neuronal signal transmission, muscle contraction, or T - cell activation.

Elowitz's team is now examining the role stochastic gene expression plays in stem cells, undifferentiated cells that give rise to the different tissues in our bodies.

Research Focus: My research projects are focused on identifying the role of different TNFSF / TNFRSF superfamily members and other co-stimulatory molecules in regulating memory Th2 and regulatory T cells during allergic lung inflammation.

We will study how signaling mechanisms impact homeostasis in cell - free, cell - based, and organismal systems, with a particular focus on the highly topical role of autophagy in different processes and studying autophagic mechanisms in depth.

The researchers believe noise could play a role, so they combine single - molecule analysis with time - lapse movies of individual cells to track random activity in many different genes as the cells switch states.

This is why recent work in the field of cancer research has focused on picking apart the complex cellular pathways involved in the development of different cancers and identifying the roles of key proteins involved, with the goal of being able to discriminately and effectively eliminate cancerous cells from the body.

Luckily, different cell types tend to have different things on their surfaces, which play particular parts in their specialized roles in the tissue, so it is a matter of identifying and targeting cell - surface markers that are specific to these abnormal cell types.

SLC16A11 belongs to a family of genes known to transport molecules across cell membranes, but the proteins that genes produce can perform many different roles in the body, and they can be active in some tissue types but not others.

While this technique is currently only available in animal models, it provides an important window into the brain generally — revealing the roles different cells play and identifying potential new targets for drug treatments in humans.

«The Notch pathway has been implicated in a number of malignancies, with different roles that are cell and tissue - type dependent,» wrote researchers led by Silvia Licciulli, PhD, of the Scripps Research Institute in Jupiter, Florida.

The Yale team found more than 580 different genes that may play a role in regeneration of axons in nerve cells, something that rarely occurs in adult mammals but is of vital interest to scientists hoping to repair injuries to the central nervous system.

Without the cells to worry about, the team took things one step further, looking to explore the role of different tissues within the plant in driving its roots toward water.

Different trials are using stromal cells isolated and transplanted in different ways with the aim to dampen the individual's immune response and / or enhance repair of the damaged tissue, but the research has yet to reveal the role these cells play in immunomoDifferent trials are using stromal cells isolated and transplanted in different ways with the aim to dampen the individual's immune response and / or enhance repair of the damaged tissue, but the research has yet to reveal the role these cells play in immunomodifferent ways with the aim to dampen the individual's immune response and / or enhance repair of the damaged tissue, but the research has yet to reveal the role these cells play in immunomodulation.

We also unraveled the role of PHD2 in different cancer cells during tumor development in mice.

EFAs or essential fatty acids play a very important role in different body functions like cell maintenance, brain development, transportation of oxygen from the lungs to the bloodstream, regulation of metabolism and mood, regulation of insulin sensitivity, as well as hormone production.

In addition, creatine helps to stabilize cellular pH (acidity) and plays an important role in balancing the different aerobic and anaerobic energy sources (eg glycolysis) which are available to the cellIn addition, creatine helps to stabilize cellular pH (acidity) and plays an important role in balancing the different aerobic and anaerobic energy sources (eg glycolysis) which are available to the cellin balancing the different aerobic and anaerobic energy sources (eg glycolysis) which are available to the cells.

While cancerous cells have a variety of different causes, excessive alcoholic intake can increase the risk of various types of cancers, including neck, liver, breast, and colorectal, and may play a role in the development of many other types of cancers, though the link has yet to be proven.