Sentences with phrase «roles in disease progression»

In fact, different genes may play a role in IA development while others play a role in disease progression, the TEDDY scientists write.

The SOD1B mutation is detected much less frequently (3 %) than the 118G > A mutation (38 %) in BMD but could play a role in disease progression.

There is a highly significant seasonal incidence of diagnosis of canine diabetes with the incidence peaking in winter, which indicates that environmental influences have a role in disease progression just before diagnosis.

Not exact matches

Not only was that assertion completely at odds with the uncertain state of the existing science, but it was contradicted by the study itself, in which Dr. McKee and her colleagues acknowledged that several other factors, besides prior participation in football, may influence CTE risk and disease severity, including factors other than cumulative hits to the head, and admitted that it was even «unclear» what roles concussions and repetitive subconcussive hits play in CTE risk, disease severity, and progression.

In collaboration with many researchers (graduate students, postdocs, and faculty elsewhere), we have examined the role of cross-immunity on the evolution and dynamics of influenza; the impact of behavioral changes, long periods of infectiousness, variable infectivity, co-infections, prostitution, social networks, and vaccine efficacy on HIV dynamics; the role of exogenous re-infection, variable progression rates, vaccination, public transportation, close and casual contacts on tuberculosis dynamics and control; the impact of life - history vector dynamics on dengue epidemics; and on the identification of time - response scales for epidemics of foot and mouth disease.

For instance, researchers have lacked useful data about how the progression of the disease itself plays a role in diminishing day - to - day physical activity.

«With this work, we are beginning to understand the role that changes in mitochondrial DNA play in the death of cholinergic neurons, which has been shown to be pivotal in the onset and progression of motor and non-motor Parkinson's disease symptoms.»

This study was designed to better define the process by which ALS progresses and to explore the role of brain motor neurons in disease development and progression.

In recent years a body of evidence has accumulated to show that chronic inflammation can play an important role in the progression of some types of tumors from a premalignant state to full - blown diseasIn recent years a body of evidence has accumulated to show that chronic inflammation can play an important role in the progression of some types of tumors from a premalignant state to full - blown diseasin the progression of some types of tumors from a premalignant state to full - blown disease.

As the messenger of genetic information, RNA plays an important regulatory role in cell and tissue development as well as during disease progression.

Next steps for the team include identifying microbiota metabolites whose levels are either significantly elevated or depleted during diseases such as IBD or cancer, to find disease - specific markers and explore possible roles for these metabolites in disease progression.

Prior evidence suggested that the variants may play a role in chronic kidney disease in blacks, however, the association of these hemoglobin traits to progression to kidney failure requiring dialysis was unknown.

Research findings indicate that abnormal CaSR function and / or abundance play a significant role in the development or progression of several non-communicable diseases (or NCDs) such as Alzheimer's disease, cardiovascular diseases, diabetes, cancer, and degenerative muscle loss.

At SAGE KE (http://www.sciencemag.org/sciext/drugdisc/#insageke), Raber describes the role of isoform - dependent interactions of apoE with androgens and androgen receptors in the progression of Alzheimer's disease.

Perhaps of greater importance than a putative interindividual transmission, the prion phenomenon may have a key role in spreading the pathology from cell to cell or from islet to islet during the progression of the disease.

A new study has found a connection between these two risk factors, in a way that highlights a role for immune responses in progression of the disease.

Shaw's research focuses on cancer metabolism: how metabolic pathways are altered in cancer and play a role in the origins and progression of the disease.

«Our findings bring us one step closer to a fuller understanding of the genetic basis of this complex disease, although more study is needed to determine the role these genetic factors may play in the onset and progression of Alzheimer's.»

Kinney is leading a team researching the role of several risk factors and subtle changes in cell function associated with Alzheimer's disease, including interactions between diabetes and inflammation in the brain in the onset and progression of Alzheimer's disease.

The study, published July 21, 2016, in Scientific Reports, also showed significant changes in the gut microbiome after antibiotic treatment, suggesting the composition and diversity of bacteria in the gut play an important role in regulating immune system activity that impacts progression of Alzheimer's disease.

Transgenic models session Chairs V.Korinek & Z. Kozmik 16.00 Bohumil Fafílek Cell tracking and manipulation in genetically modified mice 16.30 Michaela Krausová Mouse transgenic model to study tumor progression and metastasis in the gut 17.00 coffee break 17.20 Matej Durik Rodent transgenic models of cardiovascular diseases 17.50 Jan Masek The role of Wnt / beta - catenin signaling in neural crest development: an insight from transgenic and knockout mice 19.00 dinner

In conclusion, the reduction of % 24OH - CE in AD and MCI conv - AD, as well as the anticipation of the disease in patients with the lowest % 24OH - CE, support a role of the cholesterol / lecithin - cholesterol acyltransferase axis in AD onset / progressioIn conclusion, the reduction of % 24OH - CE in AD and MCI conv - AD, as well as the anticipation of the disease in patients with the lowest % 24OH - CE, support a role of the cholesterol / lecithin - cholesterol acyltransferase axis in AD onset / progressioin AD and MCI conv - AD, as well as the anticipation of the disease in patients with the lowest % 24OH - CE, support a role of the cholesterol / lecithin - cholesterol acyltransferase axis in AD onset / progressioin patients with the lowest % 24OH - CE, support a role of the cholesterol / lecithin - cholesterol acyltransferase axis in AD onset / progressioin AD onset / progression.

Overall, these data expand the prognostic role of histone modification in disease progression in PTCL - NOS.

Conclusion: The present study encourages the role of combined administration in disease management by slowing disease progression.

And even the exact role of pressure in disease progression has come under scrutiny, as sight can be preserved despite high IOP.

Oxygen Consumption measurements have become a key functional readout of cell metabolism and mitochondrial function, providing important insights into the cell function and role of perturbed metabolism in disease progression.

Science has well established that genes play a chief role in the development and progression of certain diseases.

Symposia IV: Sympatho - excitatory Mechanisms in Cardiovascular Disease Researchers will discuss the neural mechanisms behind psychogenic cardiovascular disease and the role of inflammatory cells in the progression of cardiovascular dDisease Researchers will discuss the neural mechanisms behind psychogenic cardiovascular disease and the role of inflammatory cells in the progression of cardiovascular ddisease and the role of inflammatory cells in the progression of cardiovascular diseasedisease.

Amyloid - β's role in Alzheimer's disease is controversial, and if researchers could prove that blocking its production slowed or halted the disease's progression, it would be a major breakthrough.

Dr. Holtzman conducts research on the role of infection in the development and progression of chronic airway diseases such as asthma and COPD.

«We suspect this integrated systems approach will lead us to a number of previously unsuspected genes that play a role in disease initiation and progression,» he said.

His laboratory is interested in understanding the role of metabolic adaptations in breast and prostate cancer progression, and elucidating mechanisms that promote therapy resistant aggressive metastatic disease.

Ongoing work: Led by Dr. Fasano, MIBRC researchers are looking at how qualitative or quantitative defects in the regulation of the immune system and the role of dysbiosis can lead to the onset and progression of celiac disease and other autoimmune disorders.

Since we know that stress and inflammation play a major role in contributing to cognitive impairment, studies were conducted to see if increasing the intake of strawberries and blueberries could slow down the progression of these brain - related diseases.

In this master class, we go in - depth on the gut - immune connection and why leaky gut plays a critical role in the progression of autoimmune diseasIn this master class, we go in - depth on the gut - immune connection and why leaky gut plays a critical role in the progression of autoimmune diseasin - depth on the gut - immune connection and why leaky gut plays a critical role in the progression of autoimmune diseasin the progression of autoimmune disease.

High leptin levels are very pro-inflammatory, and leptin also helps to mediate the manufacture of other very potent inflammatory chemicals from fat cells that also play a significant role in the progression of heart disease and diabetes.

The biochemistry of AD is extremely complicated and a bad diet (associated with high saturated fat intake, but not caused by it) may play a role in disease risk or progression, but it is just a small piece of puzzle.

In turn, IL - 4 may significantly inhibit the production of TNF by monocytes (Hart et al. 1989), which reinforces the potential role of adequate zinc status in preventing disease progression in HIV - 1 infection (Rosenberg and Fauci 1990In turn, IL - 4 may significantly inhibit the production of TNF by monocytes (Hart et al. 1989), which reinforces the potential role of adequate zinc status in preventing disease progression in HIV - 1 infection (Rosenberg and Fauci 1990in preventing disease progression in HIV - 1 infection (Rosenberg and Fauci 1990in HIV - 1 infection (Rosenberg and Fauci 1990).

For example, alterations in the population of intestinal bacteria of the Lactobacillus group are thought to play a role in the development and progression of several neurological disorders, including anxiety / depression, autism, multiple sclerosis and Alzheimer's disease.

Understanding the role of temperament in immune responses to disease, disease progression, and sickness behavior may improve shelter management practices, and in turn, result in improved live - release outcomes.

The discrepancies noted with respect to rate of disease progression among Swedish vallhund dogs suggest that genetic or environmental disease modifiers are likely to play a role in the pathogenesis.

• Provide education and orientation to patients and their families regarding hospital procedures • Assist patients in understanding the role medication and medical procedures will play in making them well • Develop care plans in accordance to patients» diseases and symptoms • Monitor and ensure that the care plan is being carried out in an effective manner • Resolve any problems that may affect the progression and efficacy of care plans • Foster peer support and expedite completion of tests • Review doctors» schedules and sync them with patients» appointments • Act as a liaison between care providers and patients • Take patient history and record information in preset hospital database • Work with medical staff to control disease symptoms • Create and implement disease management modules for chronic diseases • Obtain and verify insurance information • Explain the function of each health team member to patients and families • Document patient care initiatives and services on a constant basis • Ensure that appropriate referrals are made for patients not accepted for care • Schedule surgeries and prepare patient charts • Handle payment collection activities and transcribe clinical correspondence • Make sure that patients are kept aware of their progress • File and re-file patient records at the end of each shift • Ensure that all procedures are carried out in a time efficient manner and in accordance to patient care plans