Sentences with phrase «roles in lung»

Additional analysis identified other genes that may play important roles in lung cancer development.

While Rac1 has been shown to play an important role in lung cancer, its role in lung development had not yet been investigated.

Modeling APC, a gene whose role in lung cancer is not as well understood, revealed that APC loss also drives tumor progression.

«The next step is to develop antibodies or other types of drugs that can neutralize Timp - 1 to abolish its pro-proliferation role in lung cancer,» says Xia.

Not exact matches

While it was his defensive actions that impressed last season (125 tackles and 158 interceptions — the highest totals in the whole division) Kante excelled at times playing in a box - to - box midfield role due to his lung - busting stamina and eagerness to press high up the pitch.

Multiple factors play an important role in how well a baby will do including birth weight, complications of pregnancy such as placental abruption, infection, and immature lung development to name just a few.

SIgA also plays a key role in protecting susceptible areas such as the oral cavity and lungs, and it even helps us as we get older from forms of illness and stress.

This work contributed to the introduction of anti-TNF therapy in Crohn's disease and also provided the first demonstration of the role of inflammatory cytokines in lung disease affecting preterm infants.

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

Burns and her colleagues speculate that fruit plays a role because it is rich in vitamin C — also associated with healthy lungs — as well as in flavonoids, antioxidants that hamper the production of free radicals.

Although further research is needed to improve our understanding of how MSCs repair this damage, these findings suggest a promising role for MSC therapy in treating patients with chronic lung disease.

Although blood cells serve multiple roles in the body and have complex interactions with other cellular materials, most synthetic blood products have aimed to just stick to the bare basics — shuttling oxygen from the lungs to different vital organs and then bringing carbon dioxide back to the lungs to be exhaled.

The scientists conclude that in mice «well - timed treatment with rIL - 27 improved lung injury and accelerated recovery without affecting viral clearance» and continue «these data demonstrate that IL - 27 has a unique role in controlling immunopathology without impacting on host defense, and might therefore represent a promising candidate for immunomodulatory therapy of viral pneumonia.»

Stagljar and his colleagues also applied the new technology, which they dubbed MaMTH (for Mammalian - Membrane Two - Hybrid assay), to identify a protein that plays a role in the most common form of lung cancer called non-small cell lung cancer.

They looked beyond lung cancer, and discovered the KRAS - variant played a key role in half a dozen other particularly lethal malignancies, especially in women.

Inflammatory processes in lung tissue play a crucial role in the development of COPD.

«We have shown for the first time that the immune response, especially in the aged lung, plays an essential role in the pathogenesis of the disease.

The chloride channel TMEM16A can be found in different organs of the body and plays a key role in the secretion of chloride in the lung, the contraction of smooth muscles, and the perception of pain.

While previous research has found that marriage can be good for people's pulmonary health as they age, it's not the only social connection that plays a role in older adults» lung function, this study found.

The oxidative stress and resulting inflammation appear to play a role in the development of atherosclerosis (blocked arteries) and can make other health conditions worse, especially for people with existing cardiac or lung conditions including asthma.

«Unexpected role for calcium in controlling inflammation during chronic lung infection.»

To clarify their role, the Cold Spring group allowed breast tumors implanted in mice to form micro-metastases in the lungs.

B - raf gene mutations have known roles in the development of many human cancers including melanoma, lung and thyroid cancer.

Knockdown of LL34 expression leads to decreased retinoic acid signaling, suggesting that this lncRNA may play an early role in the development of the lung, as well as other tissues controlled by this pathway.

The larynx plays an important role in speaking and swallowing, but most importantly in breathing: when you breathe, the muscles of the larynx pull the vocal cords apart so that air can flow into the lungs.

In addition, researchers discovered the previously unknown role of a cancer - promoting gene in the airways of smokers with lung canceIn addition, researchers discovered the previously unknown role of a cancer - promoting gene in the airways of smokers with lung cancein the airways of smokers with lung cancer.

What's really impressive about Babar's accomplishment is that he did the work for both papers — one on the role of a population of stem cells in lung cancer development (published in Cell) the other on gene expression in group A Streptococcus (published in PNAS)-- as a participant in summer undergraduate research programs.

This interaction was previously shown to play an important role in protecting against CMV effects in the mouse spleen and lung, but is less effective in the liver.

Dental plaque may be the best - known example of a biofilm, but these slimy aggregates of bacteria also play major roles in such chronic infections as those in the urinary tract or in the lungs in cystic fibrosis patients.

«We are learning that the lung microbiome potentially plays a role in many parts of the body including cord blood cells, which may impact disease onset or symptoms.»

«Preclinical results support entinostat's role in targeting the tumor microenvironment: Entinostat inhibits function of myeloid derived suppressor cells resulting in enhanced antitumor effect in murine models of lung and renal cell carcinoma.»

«BMI1 plays a substantial role in many solid tumors, including one of the most aggressive models of lung cancer, and its expression is linked with tumor growth, invasion, metastasis, prognosis and recurrence,» Levantini said.

Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions.

Previous work at CU Cancer Center shows these drugs are especially useful against lung cancers that over-express both EGFR and HER2, implying that in addition to targeting HER2 - positive lung cancers with drugs approved to treat HER2 - positive breast cancers, there may be a role for HER2 inhibitors in HER2 cancers, perhaps both breast and lung.

Fourth, the finding of intranuclear inclusions in diseased tissues, as well as direct visualization of adenoviral - like particles (TMAdV) in lung alveoli by electron microscopy (Figs. 1D - 2 to 1D - 4), support a primary role for TMAdV in the pathogenesis of tissue injury in affected monkeys.

Further research will be needed to better understand the potential role of lung infection in Ebola and whether it may be a factor in transmission of the virus from one human to another.

«Specifically, we want to study the roles played by antibiotics, paracetamol and exposure to second - hand smoke in the relationships between respiratory tract infections and lung function or asthma.

As nutritional failure plays a role in the outcomes of many of pediatric lung diseases, I am also interested in how the GI microbiota impact early growth and nutrition.

The first experiment is to measure metastatic lung cancer in MMTV - PyMT transgenic mice crossed with the POSTN Knock out mice, and controls, with focus on the role of periostin in metastatic progression.

Among others, RET plays a role in around 50 percent of medullary thyroid cancers, 20 percent of papillary thyroid cancers, and up to two percent of non-small cell lung cancers.

The role of integrin [alpha] 8 [beta] 1 in fetal lung morphogenesis and injury.

«It will be interesting to investigate whether Wnt pathways also interact in this way with FGFs in other regions of the embryo where FGFs are also known to play an organizing role, such as the brain, lungs and other structures,» said Yasuhiko Kawakami, a member of Izpisúa Belmonte's team.

Research Focus: My research projects are focused on identifying the role of different TNFSF / TNFRSF superfamily members and other co-stimulatory molecules in regulating memory Th2 and regulatory T cells during allergic lung inflammation.

«We developed a new method of initiating lung cancer in mice, which has properties associated with human lung cancer, and used this model to identify the role of this enzyme in cancer proliferation.

Binding of JSRV sheep lung cells might interfere with the receptor's normal role in regulating cell proliferation, causing unregulated growth.

Researchers from the Universities of York and Texas have discovered that the Golgi apparatus, commonly referred as the «Cellular Post Office» plays an important role in spreading cancer from lungs to other parts of the body.

Scientists discover that a regulator of inflammation plays a key role in the proliferation of lung cancer cells

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In addition to his role at Chicago Center for Health Equity Research, Robert Winn is the primary investigator in a lab at the University of Illinois at Chicago that explores signaling pathways in lung canceIn addition to his role at Chicago Center for Health Equity Research, Robert Winn is the primary investigator in a lab at the University of Illinois at Chicago that explores signaling pathways in lung cancein a lab at the University of Illinois at Chicago that explores signaling pathways in lung cancein lung cancer.

The goal of our current studies is to understand the role of nitric oxide (and other markers in exhaled breath) in lung physiology and in the pathophysiology of lung diseases like pulmonary hypertension and asthma.