Sentences with word «rolipram»

But sleep - deprived mice that received shots of rolipram after their training remembered just as well as well - rested animals, the scientists report tomorrow in Nature.

Applying rolipram to brain slices from sleep - deprived mice restored LTP.

To confirm that extra enzyme led to sleep deprivation's effects on memory, the scientists next tried to counteract it with rolipram, a drug that inhibits PDE4A5 and other similar PDEs.

Engineered deletion of the unique N - terminal domain of the cyclic AMP - specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

In light of these life - threatening seizures, Zylka pointed out that it may be worth examining whether lower doses of rolipram, or other drugs that increase PKA activity, provide some symptom relief in Dup15q individuals.

One of the drugs, rolipram, previously had been tested in clinical trials to treat depression but was discontinued due to side effects.