HE - stained, non-infected DEF control (A); HE stained infected
cells, 52 hrs post-infection, showing
cell disruption with a large number of red - stained particles (B); Non-infected Vero
cell monolayer (C); Infected Vero
cells rounded up and focal detachment 60 hrs post-infection (D); Thin section of the infected
cell, 24 hrs post-infection, showing dense particles (
white arrow head) and virions (arrow) within the vesicles in the cytoplasm (N, nucleus).
These are anaplastic (undifferentiated
cell, characteristic of malignant neoplasms)
round cells that no longer resemble macrophages (
white blood
cells within tissues, produced by the division of monocytes) and display multiple criteria for malignancy.