The difficulty in measuring such a small increment in chromosome 21 DNA concentration has recently been overcome with the use of massively
parallel genomic sequencing.20 This technique can identify and quantify millions of DNA fragments in biological samples in a span of days.23 Three cohort studies have shown the feasibility of using the technique to identify fetuses with trisomy 21 by
analysis of maternal plasma DNA.24 25 26 The sample numbers studied were small because, typically, only a few samples could be analysed in each sequencing
run.
Analyzing deal activity by continent, there are several conclusions that
run in
parallel to the deal stage
analysis, with deals becoming more diffuse across both stage and geography as investments overall went up.