(E) Average memory - guided delayed -
saccade activity for the same example cell shown in (C).
A similar response is also evident during the self - timed
saccade activity (blue, left), although the cause is likely due to a central saccade bringing the RF to encompass the peripheral target instead of target onset since first saccades are not included in the rhythmic analysis (Figure 4C).
Not exact matches
By recording neuronal
activity in monkeys as they performed tasks that caused
saccades, Dr. Christopher Pack has shown that there are waves of
activity that cross specific vision processing areas of the brain in defined patterns, and that these patterns are reorganized by saccadic eye movements.
The observation that
activity is only correlated with the present interval implies that the correlations observed prior to central
saccades to timing do not reflect past or future planning of peripheral
saccades.
For example, if LIP
activity were strongly modulated by both central and peripheral
saccades, then a firing rate reconstruction based on only one of those
saccades would poorly predict peri-saccadic
activity for the other
saccade.
Although the predominant feature of
activity modulation during self - timed
saccades is a near linear decline in firing rate over time, other modulations are clearly present.
Specifically, we looked at whether
activity locked to a particular
saccade could completely explain the peri-saccadic
activity aligned to the other
saccade by generating firing rate predictions of each saccadic alignment on the basis of the other (Figure 5A) and behavioral variability.
Brief increases in
activity just prior to
saccade onset are followed by short intervals of decreased
activity at the time of
saccades.
Overall correlations were significant for precentral and postperipheral
saccade aligned
activity and increased from 0.050 and 0.076 to 0.145 and 0.157, respectively.
In order to determine what factors are associated with firing rate changes, we generated a prediction of neural
activity by convolving observed neural
activity aligned with one
saccade direction with the intersaccade distribution times aligned with the other
saccade direction.
Around the time of
saccade onset (± 100 ms), the
activity displays distinct modulations.
A good fit between the predicted rates (green traces) and the observed firing rates (red and blue traces) would indicate that
activity locked to a particular
saccade can largely explain the firing rate changes seen in the cyclical task.
(A and B) Average combined population
activity, grouped by interval length, aligned to central
saccades (A) and peripheral
saccades (B).
The same analysis is then repeated using
activity aligned to central
saccades.
The difference between this prediction and the observed firing rate for
activity aligned to central
saccades indicates how well
activity associated with peripheral
saccades can completely explain task - related modulations in
activity.
If LIP
activity strictly reflected a broad timing system (like those described by centralized timing models), its
activity would have a consistent relationship with time irrespective of
saccade direction.
Therefore, LIP
activity is likely related to motor planning rather than
saccade metrics.
We recorded
activity of 146
saccade - related neurons that were found in the intermediate and deep layers of the SC (about 0.5 — 3 mm below the dorsal surface).
Three different
activity measures were used to quantify the magnitude of the
saccade - related bursts of SC neurons for movements towards the center of their movement field as a function of their rostral - to - caudal location in the SC motor map: A) number of spikes in the burst, B) mean firing rate and C) peak spike density.
Citation: Goossens HHLM, van Opstal AJ (2012) Optimal Control of
Saccades by Spatial - Temporal
Activity Patterns in the Monkey Superior Colliculus.