Hence, these results indicate that, just like the saccade velocity profiles, the skewness of the bursts increases systematically with
saccade amplitude (and duration).
Note that for a given
saccade amplitude the burst profiles along the rostral - to - caudal extent of the SC appear to have very similar shapes, which change systematically as function of
saccade amplitude (and duration).
More specifically, peak firing rates in the recruited population decrease systematically with increasing
saccade amplitude while burst duration and skewness increase with increasing
saccade amplitude.
Individual trials are sorted according to
saccade amplitude and direction, respectively.
Nevertheless, the burst properties reported in this study strongly support the idea that the deeper layers of the SC act as an optimal controller: the systematic organization of peak firing rates and burst durations as function of
saccade amplitude along the motor map, the synchronous change in firing rate of recruited cells in the population, and the shaping of the temporal burst profile of a given cell with the currently planned saccade, all contribute to the generation of straight eye - movement trajectories with optimal kinematics.
This movement - field plot shows that the number of spikes in the burst (color code) varies systematically with
saccade amplitude and direction.
«These finding suggest that assessing the ability of people to adapt
saccade amplitudes is one way to determine whether this function of the cerebellum is altered in ASD,» said Edward Freedman, Ph.D. an associate professor in the URMC Department of Neuroscience and co-author of the study.
Not exact matches
This analysis shows that the peak firing rate occurs at about the same instant relative to
saccade onset (see Table 1, for further quantification) while the burst duration increases systematically with the preferred
amplitude of the cells (indexed by the gray - scaling).
We first examined the temporal discharge profiles of
saccade - related neurons along the rostral - to - caudal extent of the SC for
saccades of five particular
amplitudes.
We chose two cells from the central region of the SC (preferred
amplitudes 9.5 ° and 13.5 °, respectively) because these cells fired vigorous bursts for
saccades with distinctly different kinematics.
For both cells, peak firing rates occurred at about the same instant relative to movement onset regardless of the movement
amplitude, but burst durations were shorter and peak firing rates were higher when the cell took part in the small
saccades than when it participated in the large
saccades.