All of these cells were studied with a standard saccade task in which the animal made
saccades from an initial fixation LED to a peripheral target LED which was presented for 500 ms.. The movement field of each neuron was determined by eliciting saccades to targets inside and neighboring the response field («movement field scan»).
He said: «Examining
saccades from different populations is revealing a lot about underlying brain mechanisms and how we think.
Sommer says future experiments may inactivate more of the thalamus to see if monkeys have a harder time distinguishing their own
saccades from changes in their environment.
Not exact matches
In healthy individuals, these
saccades are rapid, precise, and accurate, redirecting the line of sight
from one point of interest to another.
The rapid eye movements we make when we shift our attention
from one object to another, known as
saccades, are essential to navigating, understanding, and interacting with the world around us.
But there has been extensive work showing that people with schizophrenia do indeed have abnormal
saccades, the fast eye movements that direct our gaze
from object to object as we explore a visual scene.
Overall correlations were significant for precentral and postperipheral
saccade aligned activity and increased
from 0.050 and 0.076 to 0.145 and 0.157, respectively.
For central
saccades (C), the p values
from left to right are: 5.5e - 13; 0.0164, 0.0001, 0, 0, 0.0001, 0.0001, 0, 0, 0.0502, 0, 0.497, 0.0012, 0.0827, 0.958, 0.0126, 0.0004; 0.0163.
After this memory - guided task, we recorded
from the same neurons while the animals performed the self - timed rhythmic -
saccade task (Figure 1A, B).
For each
saccade, the burst magnitude was quantified
from the raw data by counting all spikes in the time window between the two tick marks (identifying
saccade onset an offset with a 20 ms lead time), and the resulting spike counts are displayed in the adjacent panels as running averages.
We chose two cells
from the central region of the SC (preferred amplitudes 9.5 ° and 13.5 °, respectively) because these cells fired vigorous bursts for
saccades with distinctly different kinematics.
By driving a linear model of the brainstem with actual recorded spike trains
from a large population of SC neurons widely distributed across the motor map we obtained realistic, straight
saccades with the correct kinematic properties (Video S1).