Previous studies of the two sweeteners had shown that
saccharin activates the bitter receptor subtypes 31 and 43.
Not exact matches
Previous studies of the two sweeteners had shown that
saccharin alone
activates the subtypes TAS2R31 and TAS2R43, and cyclamate tickles TAS2R1 and TAS2R38.
In this case, though, the amount of
saccharin required to block the receptors that cyclamate
activates would have bitter effects on its own.
It turns out that
saccharin doesn't just
activate sweet taste receptors, it also blocks bitter ones — the same bitter taste receptors that cyclamate
activates.
The reverse was true, too:
Saccharin blocked TAS2R1 — one of the bitter receptors that cyclamate
activates.