To please regulators that would ultimately greenlight clinical trials, Moderna will have to show its drug is still
safe at a dose 10 times higher than what's needed to treat the disease — something the new paper doesn't demonstrate, says geneticist Michael Heartlein, chief technical officer at the competing mRNA company Translate Bio in Cambridge.
Vitamin D supplementation was found to be
safe at the doses administered.
This essential vitamin is water soluble and generally considered
safe at doses up to 2,000 mg a day, according to the Mayo Clinic.
Six human trials have demonstrated that curcumin in particular, a diferuloylmethane in turmeric, elicits significant anti-inflammatory activity, and is
safe at doses up to 8000 mg (8 grams) a day for up to three months with no toxicity (Chainani, 2003).
Turmeric, a bright - yellow spice related to ginger, is considered
safe at any dose.
He creates the impression that white asbestos is
safe at all doses.
Not exact matches
High - quality protein
dosed at 0.4 — 0.5 g / kg of LBM
at both pre - and post-exercise is a simple, relatively fail -
safe general guideline that reflects the current evidence showing a maximal acute anabolic effect of 20 — 40 g
the over-the-counter antihistamines diphenhydramine and doxylamine are
safe at recommended
doses during pregnancy, even for extended periods.
These antianxiety drugs «are known to be
safe, and we are using them
at very low levels here,» study author Scheuer notes, adding he is not concerned about human patients receiving low
doses of antianxiety drugs off - label.
An interdisciplinary team from The University of Texas Medical Branch
at Galveston and Profectus BioSciences, Inc. has developed a quick - acting vaccine that is both
safe and effective with a single
dose against the Ebola strain that killed thousands of people in West Africa last year.
Low -
dose and high -
dose OIT were
safe and equally effective
at suppressing allergic immune responses to peanut, investigators found.
Hoge acknowledges that some conditions may be off limits to mRNA drugs simply because they require higher levels of protein than the mRNA can make
at a
safe dose.
The drug, daratumumab, proved generally
safe in patients, even
at the highest
doses tested in the study.
Chemicals for killing bugs and weeds are considered
safe at low
doses — so
safe they have become a fixture of daily life.
But Calabrese suspects that in many cases, the benefits of hormesis may occur
at levels higher than the recommended
safe doses for humans.
Paracetamol is a relatively
safe painkiller when taken
at the right
dose.
Radiotherapy given in high
doses over a shorter period of time is
safe and effective for prostate cancer patients, according to research presented
at the ESTRO 37 conference today.
Tabrizi - «The drug was
safe and well tolerated
at all
doses tested».
Barcelona, Spain: Radiotherapy given in high
doses over a shorter period of time is
safe and effective for prostate cancer patients, according to research presented
at the ESTRO 37 conference today.
In this study, NPT088 was
safe and well - tolerated
at multiple
dose levels, with a suitable pharmacokinetic profile.
In traditional cultures, it is generally considered
safe for use (even regularly or
at moderate
doses) but because it does stimulate the immune system, I am careful not to overuse with my autoimmune disease.
Because TMS has already been shown to be
safe for the treatment of depression — and
at much higher
doses (i.e., the number of pulses)-- it offers a «gigantic margin of safety» to migraine patients, Dr. Lipton says.
While they don't recommend consuming no carbs
at all, and neither do we, it goes to show that extremely low
doses are not only
safe but natural as well.
Dr. Justin Marchegiani: So we just go back, quarter, half, three - quarters, full or we just start
at a quarter half and then increase and any negative reactions, back off to the last
safest dose, or — and then move on to the next supplement.
I try to get a healthy
dose (20 mins
at noon) of sun when the weather is good here in Portland (Oregon), but since that's fairly limited, I'm intrigued by this light idea and it's potential benefits over supplementation with synthetic D. Do you think basking under a full spectrum UVA / UVB light is a
safe option?
Curcumin is considered one of the
safest medicinal spices in the world, even
at high or mega
doses.
Recent studies show that it is
safe to use daily
doses of 4000 IU and more to maintain serum 25 (OH) vitamin D
at the healthy levels between 50 and 80 ng / mL.
Natural phytochemicals
at the low levels present in fruit and vegetables offer health benefits, but these compounds may not be effective or
safe when consumed
at higher
doses, even in a pure dietary supplement form.
Vitamin A
at high
doses can be toxic to the body, but it is added into this product
at a
safe dose of 5000 IU.
In addition, this same study noted that turmeric has been found to be pharmacologically
safe, with no toxicity noted
at doses up to 10 grams per day.
The jury is still out on whether iodine in supplemental form is
safe (especially
at higher
doses).
For decades previously, serrapeptase had been sold as a
safe and ethical medicine in Japan and Germany but
at some very low
doses.
Scientific opinions range anywhere from «
safe under all conditions» to «unsafe
at any
dose.»
At low
doses, usually less than 4.5 mg per day, naltrexone is considered very
safe and has few side effects.
Maybe YOUR pre-workout sucks, but ours contains several scientifically proven,
safe performance enhancing ingredients
at clinically effective
doses.
And numerous studies conducted to test the herbs» toxicity levels have shown that Tongkat Ali is
safe to be consumed even
at higher
doses.
looking
at what the science says about the most common artificial sweeteners and what are
safe doses.
However,
at very large
doses of cod liver oil or if you somehow overate large quantities of liver, it still is possible to overdose on natural Vitamin A from these types of sources (although this natural form is
safer than the synthetic vitamin A palmitate).
And it's exactly the excess consumption of fat is what we are not naturally protected from by our bodies, while being encouraged to it by modern LC proponents.A substance one needs to be careful with basically, but
safe at appropriate
doses.
In fact, studies have found that high
doses of natural vitamin A are
safe and effective
at decreasing childhood mortality and morbidity in Ghana and curing 92 % of women suffering from menstrual hemorrhage.
Although selenium is generally considered
safe at standard
doses, very high dosage can cause selenium toxicity.
At the low DRI
doses, niacin is
safe for everyone.
And we couldn't be more thrilled,
safe in the knowledge that the perfect
dose of Parisian pizzazz is
at the click of our heels.
Yes, it's easier to remember to give the meds
at the beginning of every month; but it's
safer for your dog to reduce the
dosing frequency to every 45 days — that's 4 fewer
doses a year if you use the drugs year - round.
The coxib class is actually COX selective, not merely COX preferential, which means that
at usual
doses it completely inhibits COX - 2 and completely leaves COX - 1 alone, potentially making a
safer drug.
It has minimal side effects, and has been shown to be
safe at up to 5 times the recommended
dose.
Collie - type dogs are more sensitive to nervous - system effects than other dogs, but even in these breeds, the products are
safe at recommended
doses.»
This 6 - month laboratory study supports the
safe use of Onsior Tablets for Dogs
at a
dose of 2 mg / kg / day for the labeled 3 - day duration.
Some of the medications are okay
at standard
doses, but all have alternatives so should generally be avoided just to be
safe.
In most cases this treatment is
safe and effective but some individuals have a mutation that makes ivermectin toxic
at the
doses used to kill mites.