Sentences with phrase «safety pharmacology studies»
Nonclinical in vivo assessment of QT interval in cardiovascular safety pharmacology studies has limited predictive value as well, often necessitating a «Thorough QT» clinical study later in development.
https://www.sciencedaily.com/ Not exact matches
The brochures contain information about toxicology, pharmacology, and animal safety studies used to determine the potential risk a particular therapy may pose to humans, but they also include efficacy studies done in animal models to demonstrate a therapy's potential benefit.
«This is encouraging because the safety profile of anti-muscarinic drugs is well - characterized, with more than 20 years of clinical application for a variety of indications in Europe,» said senior study author Paul Fernyhough, PhD, professor in the departments of pharmacology and therapeutics and physiology at the University of Manitoba in Canada.
«We are at a point in our research where we have validated the efficacy of this combination treatment approach in preclinical animal models, and we now need to define its safety through toxicology and pharmacology studies,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, chairman of VCU School of Medicine's Department of Human and Molecular Genetics and director of the VCU Institute of Molecular Medicine.
DanioVision is a complete system designed for exactly these types of experiments with zebrafish larvae, and is often used in studies related to drug development, safety pharmacology, behavioral genetics, and circadian rhythmicity.
EthoVision XT is used in a wide range of fields, mostly related to neurosciences, such as toxicology, safety pharmacology, psychopharmacology, drug discovery, molecular biology, genetics, behavioral neurosciences, but also in applied ethology, and animal welfare studies.
«based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential»
Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, beyond the information included in other sections of the SmPC.