Sentences with phrase «safety profile with»
We believe CMB305's potential benefit to patients will be the combination of a favorable safety profile with improved survival, and as such are focused on overall survival and safety as the primary endpoints of these studies.
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There were no changes in the safety profile with repeated doses of ISIS - SMNRx.
The therapy had a favorable safety profile with the most common adverse event reported as irritation at injection site, which was reported in the placebo group as well.
Not exact matches
«This investigational single tablet regimen brings together the potency of an integrase inhibitor, bictegravir, with the demonstrated efficacy and safety profile of the FTC / TAF backbone,» said Norbert Bischofberger, executive vice president, research and development and chief scientific officer, Gilead Sciences.
Based on conversation with physician experts, SunTrust said it believes LJPC - 501 hits on multiple characteristics of a successful drug, including effectiveness at improving MAP, a good safety profile, easily titratable and positive mortality benefit as supported by a statistically significant reduction in CV SOFA score.
However, regardless of whether a member has verified their profile with us, we strongly encourage you to read and follow the Safety Tips for Co-Parent «Dating» information that we have provided on our site.
Due to a number of high - profile legal cases, [20] many manufacturers now produce goods with built - in safety measures, such as child - resistant locks.
The MESA has an extremely low profile and slim base with a finished bottom to protect car upholstery and eliminates the need for seat protectors, which can compromise car seat installation and safety.
They use a lot of synthetic ingredients, but seem to choose the ones with the best safety profiles.
Up for debate is the Community Safety Act, which would create a new NYPD inspector general charged with monitoring the department and providing independent oversight, following growing complaints over racial and ethnic profiling.
«Until we have further evidence on the efficacy of medical cannabis for the treatment of sleep apnea, and until its safety profile is established, patients should discuss proven treatment options with a licensed medical provider at an accredited sleep facility,» said lead author Dr. Kannan Ramar, professor of medicine in the division of pulmonary and critical care medicine at Mayo Clinic in Rochester, Minnesota.
In general, the researchers found liraglutide 3 mg to have a safety profile that was similar to that found in previous clinical trials of the drug in individuals with Type 2 diabetes treated with lower doses.
With A3AR drugs demonstrating good safety profiles in clinical trials as anti-inflammatory and anti-cancer agents, Salvemini and colleagues are enthusiastic about the potential of these new drugs to treat chronic pain in patients.
«The way forward is to come up with new vaccines that provide long - lasting immunity as well as a strong safety profile.»
«We saw substantial decreases at 2.5 percent of BA and nearly complete protection at the 10 percent concentration, strongly indicating that insect repellents with good safety profiles can be useful to reduce fruit damage during ripening.»
«We are achieving the same or higher cure rates in many patients with sofosbuvir, compared to interferon, and we are doing it in half the time with a drug that has a remarkable safety profile.»
Our Zika vaccine showed promising safety profile in mice when compared with clinically approved live - attenuated vaccines, such as the yellow fever vaccine,» Shi said.
Working with a leading company on fire safety engineering has meant «instant recognition at conferences» and has raised his profile for future job opportunities.
«To date, this type of system has only been used in humans with viral methods of gene delivery, of which the safety profiles are still heavily in debate,» says Betty Tyler, associate professor of neurosurgery at Johns Hopkins.
The therapy was found to have an acceptable safety profile in all patients, with no clinical or laboratory signs of systemic cytokine release syndrome, a potentially serious toxicity that has been observed in other CAR trials.
«This is encouraging because the safety profile of anti-muscarinic drugs is well - characterized, with more than 20 years of clinical application for a variety of indications in Europe,» said senior study author Paul Fernyhough, PhD, professor in the departments of pharmacology and therapeutics and physiology at the University of Manitoba in Canada.
Regorafenib had a similar safety and side effect profile to sorafenib, with hypertension, hand - foot skin reaction, fatigue and diarrhea all being significantly more common in patients taking the drug.
Furthermore, the safety profile was consistent with the safety outcomes of the double - blind phase and other trials using T - sol.»
Will the same safety profile and functionality occur with other progenitors generated and transplanted using this strategy?
The Phase 1 study of ISIS - SMNRx is a single - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 14 who are medically stable.
Patients using less common drugs and non-prescription medications could be more at risk for harmful interactions because health care providers may be less familiar with their safety profile.
Preliminary trials of these drugs (for treatment of other forms of cancer) have shown that they have a good safety profile, which should accelerate testing in patients with glioblastoma.
An innovative experimental treatment for boosting the effectiveness of stem - cell transplants with umbilical cord blood has a favorable safety profile in long - term animal studies, report scientists from Dana - Farber Cancer Institute, Beth Israel Deaconess Medical Center (BIDMC), and Children's Hospital Boston (CHB).
It is also a two - part study with the first part being an open - label dose escalation study in at least 8 infants for 4 weeks to evaluate the safety profile of RG7916 and to determine the dose for Part 2.
Although these studies were limited to small patient numbers, given the rarity of this disease, PD - 1 pathway blockade seems to have clinical efficacy in mucosal melanoma, with a tolerable safety profile.
The safety profile for ADRCs is well - established in regenerative medicine with no toxicity in thousands of patient data sets.
The good safety profile of Aducanumab in patients may well be attributed to the antibody's specific capacity to bond with the abnormally folded beta - amyloid protein fragment as well as the fact that the antibody is of human origin.
As a consequence, bardoxolone has a complicated pharmacological and toxicological profile with significant clinical safety problems.
Given the rather divergent toxicology and adverse event profiles seen with bardoxolone and DMF, we conclude that induction of Nrf2 can be advantageous, but that the electrophilic character of the molecule is crucial and thus sets significant limitations on the safety and efficacy of such compounds.
Particularly in the area of neurodegeneration, attention has been drawn to repurposing existing drugs with proven efficacy and safety profiles.
«Given that salsalate is a prescription drug with a long - history of a reasonable safety profile, we believe it can have immediate clinical implications.»
The Phase 1b / 2a study of ISIS - SMNRx is a multiple - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 15 who are medically stable.
The blockade of immune checkpoints with antibodies (Ab) anti-CTLA-4, anti-PD1 and anti-PD-L1, has given impressive clinical results and manageable safety profiles.
A recent study showed that T - VEC in combination with ipilimumab resulted in an overall response rate of 50 %, durable response rate of 44 %, and tolerable safety profile in patients with advanced melanoma, said Georgina Long, BSc, PhD, MBBS, of the Melanoma Institute Australia in Sydney.
Although both forms are highly active, ADCs with alkylating IGNs demonstrated a better safety profile, and high therapeutic indices in vivo.23, 24 Here we describe the development and preclinical characterization of a novel CD123 - targeting ADC, IMGN632, consisting of a humanized anti-CD123 antibody conjugated to an alkylating IGN payload via a protease cleavable linker.
Although existing interventions have helped to reduce malaria deaths significantly over the past 15 years, a well - tolerated and effective vaccine with an acceptable safety profile could add an important complementary tool for malaria control efforts.
Importantly, IMGN632 was effective at concentrations well below those that affected normal bone marrow cells, suggesting the potential for efficacy in AML patients with reduced likelihood of myelosuppressive side effects and favorable safety profile.
Elos laser hair removal provides effective hair removal technology with an excellent safety profile.
Bioidentical hormones therefore have an excellent safety profile and do not carry the risks that have been well documented with synthetic or conventional hormone therapy, which include increased risk of heart disease, stroke, or breast cancer.
If one is concerned about biotin, there are many healthy plant - based options with overall higher nutrient density profiles and without the many safety concerns associated with eggs, including increased IGF - 1, methionine, industrial pollutants, oncogenic viruses, arachidonic acid, cholesterol, and saturated fat.
In fact, it's safety profile is on par with Synephrine, one of the safest fat - loss supplements that actually works.
Because intermittent fasting and CR have not been conclusively proven to have beneficial effects in humans with acceptable safety profiles (1), they were not considered to be controls for trials that were identified.
Unlike other popular pre-workout powders, BRX doesn't contain any mystery ingredients with unknown safety profiles or banned substances like 1,3 dimeth.
They've taken two drugs that have been around for a very long time with relatively good safety profiles and put them together, hoping that the combined action might be better at controlling eating,» says Paul Kenny, PhD, associate professor of molecular therapeutics at Scripps Research Institute in Jupiter, Fla. «It's a double whammy.»
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