«The interesting thing is that when we looked
the same dog genes in human breast cancer, epigenetic aberrations occur in the same regions of DNA.
Not exact matches
It makes sense that only a few
genes would suffice to determine a trait such as body size, Ostrander says, because all
dog breeds belong to the
same species, Canis familiaris, and most have taken shape in the last three centuries.
Because
dogs suffer from many of the
same afflictions that can strike people — cancer, heart disease and diabetes, among them — the authors hope that Fidos genome will help narrow the search for disease - causing
genes in his owner.
The
dogs were chosen because they have inherited a genetic disease caused by the
same gene defect as some patients with human retinitis pigmentosa.
Not only do black - furred
dogs and wolves have the
same gene variant, but the DNA surrounding the K locus is also quite similar — and quite different from that of gray wolves — suggesting that the variant was introduced when wolves interbred with domestic
dogs.
Humans have the
same genes as the ones identified by the researchers in
dogs.
The paucity of single nucleotide diversity among breeds is consistent with other studies (29 — 32) and stands in stark contrast to the abundance of coding repeat variation we found in these
same genes known to be involved in the developmental processes under selection in the radiation in
dog breed morphologies.
Purpose: Many current studies are aimed at trying to identify
genes associated with diseases in
dogs, but we are looking to see if there might exist «protective
genes» that could help protect against these
same life - limiting diseases in the
dog.
First it will be necessary to formally exclude the COMMD1
gene by sequencing all of COMMD1 in a small number of affected
dogs that are known to not carry the COMMD1 deletion to ensure there is not a second mutation in the
same gene.
The
same genes (from related
dogs) keep on being bred to each other, so there is no external blood and genetic material being added.
Though some say that mixed breed
dogs are inherently healthier than pure breeds simply because they have a larger
gene pool, if both parent breeds are prone to the
same diseases a mixed breed will have a higher risk for getting those diseases.
Since all
dogs with CEA have CH it can be managed in the
same way one would manage any single
gene recessive trait even though other as - yet unidentified
genes cause the more serious defects.
A
dog bred from mixed ancestry is less likely to inherit defective
genes for the
same disease from both parents.
Plus, we know that purebred
dogs can be sensibly more at risk with inherited medical conditions because they are all coming from the very
same closed
gene pool of the few
dogs that started the breed.
The
same with
dogs, you have to introduce new
genes.
If you breed two
dogs of the
same or similar color, there is a good chance that the puppies will be that color too, though you must always account for recessive
genes.
This research benefits humans too, because the
genes involved in cancer are sometimes the
same in
dogs as in people, but the mutations can be more difficult to discover in people.
(ref) The problem is that some
dogs that carry these
genes will never develop the disease (incomplete or variable penetrance) while others that appear free of those
genes develop cardiomyopathy (DCM) all the
same.
While no two
dogs are the
same, the
genes associated with a breed can affect behaviours, illnesses and traits.
This means that all
dogs of a certain breed are in some way related and thus, have the
same genes in their lineages.
And just because the clones have the
same genes as the original
dogs, Hyun says that doesn't necessarily mean they're really carbon copies.
ALL affected
dogs, regardless of the actual severity of the lesions, are homozygous for the
same mutant
gene.
As
dogs are a subspecies but their breeds are distinct genetic units, and because only certain breeds share the
same type of cancers as humans, the differences in the
genes of different breeds may be useful in human medical research.
The
same study found that a
gene that acts as a marker of cell damage was higher in
dogs living in smoking homes than those in nonsmoking homes.
TheDogPress.com recently ran something about that
same university discovering a
gene in Rhodesian Ridgebacks that rescue human epileptics # 1 but right now I want to tell you about the lung disease research in
dogs.
Then lower on that
same page I saw the article about «Breathtaking
Gene Discovery in Dalmatians» about acute respiratory distress syndrome (ARDS), and further googling led me to... «A progressive pulmonary disease resulting in severe respiratory failure and death in an average of 3 weeks was diagnosed in 11 young Dalmatian
dogs.
In collaboration with veterinary neurologists in England, researchers at the Hospital for Sick Children compared the
genes known to be associated with Lafora to the
same genes in affected
dogs.
A Golden Retriever is a Golden Retriever and they naturally come in different shades, from almost red to almost pure brilliant white, but they are all the
same dog,
same genes,
same color, just different shades.
It represents the chance that a
dog will inherit a homozygous pair of alleles from an ancestor on both sides of the pedigree, or that a given percentage of a
dog's
genes will have homozygous
genes (i.e. the
same genes).
However, hybrid
dogs typically have much fewer genetic problems than purebred
dogs do because even though breeders are mating two different types of first generation purebred
dogs, the
gene pool is still mixed more than it would be after mating two purebred animals of the
same breed.
As it is accepted, the shepherd
dogs have the
same genes as the wolf.
In the
same way that inbreeding among human populations can increase the frequency of normally rare
genes that cause diseases, the selective breeding that created the hundreds of modern
dog breeds has put purebred
dogs at risk for a large number of health problems, affecting both body and behavior.
Researchers have identified genetic mutations that cause similar problems in other breeds of
dogs and they want to compare those
genes to the DNA in French Bulldogs to see if the
same mutation might be responsible for the condition.
now you will probably say the american staffordshire is the
same yet when a study done on the
genes of working
dogs vs show
dogs of the
same breed was done it showed that the working type was genetically different from the show type.
Unlike
dogs, which have evolved
genes to help digest starch since they separated from wolves, cats don't have the
same capacity.
Roughly the
same situation occurs with a dominant disease that has a post - reproductive age of onset, since as many as half of the offspring of an affected
dog will become afflicted in their lifetime, but not until they have passed on the disease
gene to half of their offspring.
The
same ancestral autosomal recessive mutation for the progressive rod cone degeneration (prcd) form of progressive retinal atrophy (PRA) is found in the American Cocker Spaniel, American Eskimo
Dog, Australian Cattle
Dog, Australian Shepherd, Chesapeake Bay Retriever, Chinese Crested
Dog, English Cocker Spaniel, Entelbucher Mountain
Dog, Finnish Lapphund, Golden Retriever, Kuvasz, Labrador Retriever, Lapponian Herder, Norwegian Elkhound, Nova Scotia Duck Trolling Retriever, Poodle, Portuguese Water
Dog, Silky Terrier, Spanish Water
Dog, Stumpy Tail Cattle
Dog Swedish Lapphund, and Yorkshire Terrier.3 This list continues to grow as more breeds are discovered with the
same defective
gene.
Dogs and wolves have the
same number of copies of another
gene, MGAM, which codes for maltase, another enzyme important in starch digestion.
Homozygous means both copies of the
gene in your
dog are the
SAME - both normal or both prcd.
Nevertheless, white
dogs can still be registered with the American Kennel Club as German Shepherds, and whatever their color, those AKC
dogs all share essentially the
same genes, including health
genes.
Whatever their color, those
dogs all share essentially the
same genes.
Reputable / Quality Breeders can still have a Fawn or Blue marked pup show up in their lines for if they breed with another
dog who has the
same «recessive» fawn or blue
gene; it can produce mismark puppies such as Porcelains or Fawnequins etc..
Although moxidectin is in the
same drug family as ivermectin, some veterinarians use it, combined with imidacloprid (Advantage Multi ®) to treat mange successfully — even in
dogs with the MDR1 aka ABCB1
gene mutation.
But it is a very bad idea to breed
dogs and cats that are cryptorchid because their descendants will carry the
same defective
genes.
In a previous study (Mäki et al, 2002) on the
same breeds and data sets, no indication of major
genes was found based on within - sire phenotypic distributions of the left hip and elbow joints of the
dogs.
Since it takes 2 recessive
genes (one from the mother and one from the father) in the
same puppy to produce a
dog with PRA, this inherited disease is difficult to remove from a breed.
Although moxidectin is in the
same drug family as ivermectin, some veterinarians use it, combined with imidacloprid (Advantage Multi ® aka aka Advocate Spot On ®) to treat mange successfully — even in
dogs with the MDR1 aka ABCB1
gene mutation.
In evaluating the hips of
dogs genetically predisposed to dysplasia, certain factors could make the hips in the leg - extended radiographs appear worse, compared to another
dog with presumably the
same genes for hip joint construction, such as a littermate or a
dog with otherwise near - identical genotype yet reared differently.
Although the visual effect can be the
same, it is easy to confuse this with the subtle hint of bronze (liver) that shows through in coats of some black
dogs that carry an incompletely - masked recessive allele (one of the
gene pair) for «a dilute» such as liver - chocolate.
The fact that the affected
dogs do not share common alleles in any loci and
same alleles were present in both cases and controls excludes these known PRA
genes as candidates.